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公开(公告)号：US10786488B2
公开(公告)日：2020-09-29
申请号：US16479997
申请日：2018-01-23
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Tao Yu , John A. McCauley , Alan Whitehead , James M. Apgar , Izzat T. Raheem , Guizhen Dong , Sherman T. Waddell , Hong Li
IPC: A61K31/4375 , A61K31/427 , A61K31/4402 , A61K31/47 , A61K31/506 , A61K31/5365 , A61K31/675 , A61K31/7068 , A61K31/7076 , C07D491/147
Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US10548910B2
公开(公告)日：2020-02-04
申请号：US15775966
申请日：2016-11-11
Applicant: Merck Sharp & Dohme Corp.
Inventor： Thomas H. Graham , Tao Yu , Sherman T. Waddell , John A. McCauley , Andrew Stamford , Wensheng Liu , Jay A. Grobler , Libo Xu
IPC: A61K31/675 , A61P31/18 , A61K31/683 , A61K31/34 , A61K31/426 , A61K31/44 , A61K31/513 , A61K31/52 , A61K31/535 , A61K31/7068
Abstract: The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R1, R2 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US10081647B2
公开(公告)日：2018-09-25
申请号：US15560896
申请日：2016-03-25
Applicant: Merck Sharp & Dohme Corp.
Inventor： Tao Yu , Sherman T. Waddell , John A. McCauley , Thomas H. Graham , Hong Li , Izzat Raheem , Jay A. Grobler
IPC: A61K31/675 , C07F9/6561 , A61K31/683
CPC classification number: C07F9/6561 , A61K31/427 , A61K31/4402 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K31/683 , A61K2300/00
Abstract: The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Phosphate Substituted Quinolizine Derivative, and methods of using the Phosphate Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US09714243B2
公开(公告)日：2017-07-25
申请号：US14652580
申请日：2013-12-12
Applicant: Merck Sharp & Dohme Corp.
Inventor： Mark W. Embrey , Thomas H. Graham , Abbas Walji , Sherman T. Waddell , Tao Yu , Yonglian Zhang , Wensheng Liu , Paul J. Coleman , John Wai , Thomas Steele , Christina Di Marco
IPC: C07D471/04 , A61K31/53 , C07D471/10 , C07F9/6521 , A61K31/675 , A61K31/55 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14
CPC classification number: C07D471/04 , A61K31/4985 , A61K31/53 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/10 , C07D471/14 , C07D471/20 , C07D491/20 , C07D495/20 , C07D498/14 , C07F9/6521
Abstract: The present invention relates to 4-Pyridinonetriazine Derivatives of Formula (I); and pharmaceutically acceptable salts thereof, wherein A, X, Y, R1, R2, R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one 4-Pyridinonetriazine Derivative, and methods of using the 4-Pyridinonetriazine Derivatives for treating or preventing HIV infection in a subject.
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15.发明申请公开(公告)号：US20160228419A1
公开(公告)日：2016-08-11
申请号：US15025038
申请日：2014-09-26
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Tao Yu , Yonglian Zhang , Sherman Tim Waddell , Andrew Stamford , John S. Wai , Paul J. Coleman , John M. Sanders , Ronald Ferguson
IPC: A61K31/4375 , C07D455/02 , C07D519/00 , C07D471/14 , A61K31/444 , C07D455/04 , C07D455/00 , A61K45/06 , C07D491/147
CPC classification number: A61K31/4375 , A61K31/427 , A61K31/4402 , A61K31/444 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K45/06 , C07D455/00 , C07D455/02 , C07D455/04 , C07D471/14 , C07D491/147 , C07D519/00 , A61K2300/00
Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
Abstract translation: 本发明涉及式（I）的取代的喹诺嗪衍生物及其药学上可接受的盐或前药，其中X，Y，R 1，R 2，R 3，R 4，R 5，R 9和R 10如本文所定义。 本发明还涉及包含至少一种取代的喹啉衍生物的组合物，以及使用取代的喹喔啉衍生物治疗或预防受试者中HIV感染的方法。
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Patent Agency Ranking
公开(公告)号：US20190315769A1
公开(公告)日：2019-10-17
申请号：US16447271
申请日：2019-06-20
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Thomas H. Graham , Tao Yu , Yonglian Zhang , John A. McCauley
IPC: C07D498/22 , A61P31/18 , C07D498/16 , C07D487/16 , A61K31/553 , A61K31/4188 , A61K31/407 , A61K31/5365 , A61K31/4985 , C07D471/22
Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and R7 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20180325926A1
公开(公告)日：2018-11-15
申请号：US15775871
申请日：2016-11-11
Applicant: Merck Sharp & Dohme Corp.
Inventor： Thomas H. Graham , Tao Yu , Sherman T. Waddell , John A. McCauley , Andrew Stamford , Wengsheng Liu , Jay A. Grobler , Libo Xu
IPC: A61K31/675 , A61P31/18
CPC classification number: A61K31/675 , A61K31/426 , A61K31/513 , A61K31/52 , A61K2300/00 , A61P31/18 , C07D491/20 , C07F9/6561
Abstract: The present invention relates to Spirocyclic Pyridotriazine Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R16 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Pyridotriazine Derivative, and methods of using the Spirocyclic Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US20180037554A1
公开(公告)日：2018-02-08
申请号：US15549242
申请日：2016-02-01
Applicant: Merck Sharp & Dohme Corp.
Inventor： Amjad Ali , Rongze Kuang , Yeon-Hee Lim , Michael Man-Chu Lo , Pauline C. Ting , Purakkattle Biju , Manuel de Lera Ruiz , Sylvia J. Degrado , Alexander L. Tung , Timothy J. Henderson , Liwu Hong , Jae-Hun Kim , Dong Won-Shik Kim , Joe Lee , Jie Wu , Heping Wu , Yushi Xiao , Tao Yu , Gang Zhou , Xiaohong Zhu , Kevin D. McCormick , Jayaram R. Tagat , Dong Xiao , Tanweer Khan , Jianhua Cao , Michael Berlin , Yonglian Zhang
IPC: C07D239/84 , C07D401/14 , C07D413/12 , C07D417/12 , C07D405/12 , C07D417/14 , C07D413/14 , C07D471/04 , C07D401/12 , C07D403/12
CPC classification number: C07D239/84 , A61K31/517 , A61P25/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
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公开(公告)号：US20180028509A1
公开(公告)日：2018-02-01
申请号：US15725407
申请日：2017-10-05
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Tao Yu , Yonglian Zhang , Sherman Tim Waddell , Andrew Stamford , John S. Wai , Paul J. Coleman , John M. Sanders , Ronald Ferguson , Thomas H. Graham , Hong Li
IPC: A61K31/4375 , C07D519/00 , A61K31/52 , A61K31/513 , A61K31/505 , A61K31/4745 , A61K31/4402 , A61K31/427 , A61K31/635 , A61K31/444 , C07D455/00 , C07D455/04 , C07D471/14 , C07D491/147 , A61K45/06 , A61K31/675 , C07D455/02
CPC classification number: A61K31/4375 , A61K31/427 , A61K31/4402 , A61K31/444 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K45/06 , C07D455/00 , C07D455/02 , C07D455/04 , C07D471/14 , C07D491/147 , C07D519/00 , A61K2300/00
Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US09861620B2
公开(公告)日：2018-01-09
申请号：US15025038
申请日：2014-09-26
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Tao Yu , Yonglian Zhang , Sherman Tim Waddell , Andrew Stamford , John S. Wai , Paul J. Coleman , John M. Sanders , Ronald Ferguson , Thomas H. Graham , Hong Li
IPC: A61K31/44 , C07D491/02 , C07D491/00 , C07D221/00 , C07D453/00 , A61K31/4375 , C07D455/02 , A61K31/427 , A61K31/4402 , A61K31/444 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , C07D455/00 , C07D455/04 , C07D471/14 , C07D491/147 , A61K45/06 , C07D519/00
CPC classification number: A61K31/4375 , A61K31/427 , A61K31/4402 , A61K31/444 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K45/06 , C07D455/00 , C07D455/02 , C07D455/04 , C07D471/14 , C07D491/147 , C07D519/00 , A61K2300/00
Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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