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公开(公告)号：US20190183912A1
公开(公告)日：2019-06-20
申请号：US16327631
申请日：2017-08-22
发明人： Daniel Da Costa , Cyril B. Dousson , David Dukhan , Jean-Laurent Paparin , Houcine Rahali , Izzat Raheem
IPC分类号： A61K31/675 , A61P31/12
CPC分类号： A61K31/675 , A61K45/05 , A61K45/06 , A61P31/00 , A61P31/12 , C07F9/65616
摘要： Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US10081647B2
公开(公告)日：2018-09-25
申请号：US15560896
申请日：2016-03-25
发明人： Tao Yu , Sherman T. Waddell , John A. McCauley , Thomas H. Graham , Hong Li , Izzat Raheem , Jay A. Grobler
IPC分类号： A61K31/675 , C07F9/6561 , A61K31/683
CPC分类号： C07F9/6561 , A61K31/427 , A61K31/4402 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K31/683 , A61K2300/00
摘要： The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Phosphate Substituted Quinolizine Derivative, and methods of using the Phosphate Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US10449208B2
公开(公告)日：2019-10-22
申请号：US16327631
申请日：2017-08-22
发明人： Daniel Da Costa , Cyril B. Dousson , David Dukhan , Jean-Laurent Paparin , Houcine Rahali , Izzat Raheem
IPC分类号： A61K31/675 , A61P31/12 , A61K45/00
摘要： Compounds of Formula I: and pharmaceutically acceptable salts and co-crystals thereof are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US20180051043A1
公开(公告)日：2018-02-22
申请号：US15560896
申请日：2016-03-25
发明人： Tao Yu , Sherman T. Waddell , John A. McCauley , Thomas H. Graham , Hong Li , Izzat Raheem , Jay A. Grobler
IPC分类号： C07F9/6561 , A61K31/683 , A61K31/675
CPC分类号： C07F9/6561 , A61K31/427 , A61K31/4402 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/635 , A61K31/675 , A61K31/683 , A61K2300/00
摘要： The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Phosphate Substituted Quinolizine Derivative, and methods of using the Phosphate Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US11123355B2
公开(公告)日：2021-09-21
申请号：US16471304
申请日：2017-12-19
发明人： Manuel de Lera Ruiz , Timothy J. Hartingh , Izzat Raheem , John Schreier , Jean-Laurent Paparin
IPC分类号： A61K31/675 , A61K31/522 , A61K31/505 , A61K31/34 , A61K31/44 , A61K31/4965 , A61P31/18 , A61K31/496 , A61K31/536 , C07D473/34
摘要： Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US10519159B2
公开(公告)日：2019-12-31
申请号：US15847971
申请日：2017-12-20
IPC分类号： C07D473/34 , A61K45/06 , A61P31/18 , A61K31/52 , A61K31/675 , C07F9/6561 , A61K9/00
摘要： Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US20190321380A1
公开(公告)日：2019-10-24
申请号：US16471304
申请日：2017-12-19
发明人： Manuel de Lera Ruiz , Timothy J. Hartingh , Izzat Raheem , John Schreier , Jean-Laurent Paparin
IPC分类号： A61K31/675 , A61P31/18 , A61K31/536 , A61K31/496 , C07D473/34
摘要： Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US20190177326A1
公开(公告)日：2019-06-13
申请号：US16212121
申请日：2018-12-06
IPC分类号： C07D473/40 , A61K31/675 , A61K31/7072 , A61K31/522 , A61K31/52 , A61K31/513 , C07F9/6561 , C07D473/32 , C07D239/54 , C07D239/47
摘要： The present invention is directed carbocyclic nucleoside reverse transcriptase inhibitors compounds of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.
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公开(公告)号：US20180179208A1
公开(公告)日：2018-06-28
申请号：US15847971
申请日：2017-12-20
IPC分类号： C07D473/34 , A61K31/52 , A61P31/18 , A61K45/06
摘要： Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines
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公开(公告)号：US09822138B2
公开(公告)日：2017-11-21
申请号：US15231365
申请日：2016-08-08
发明人： Petr Vachal , Izzat Raheem , Zhiqiang Guo , Timothy John Hartingh
IPC分类号： C07F9/6561 , A61K45/06 , A61K31/675 , C07F9/16
CPC分类号： C07F9/65616 , A61K31/675 , A61K45/06 , C07F9/16
摘要： Compounds of Formula I: and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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