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公开(公告)号:US08232391B2
公开(公告)日:2012-07-31
申请号:US12833682
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号: C07D279/10 , A61K31/54
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
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公开(公告)号:US20100280240A1
公开(公告)日:2010-11-04
申请号:US12833621
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brain J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brain J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
IPC分类号: C07D487/04 , C07D471/04 , C07D417/14 , C07D403/14 , C07D498/04
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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公开(公告)号:US20060223810A1
公开(公告)日:2006-10-05
申请号:US11393558
申请日:2006-03-30
申请人: Brett Allison , Laurent Gomez , Cheryl Grice , Michael Hack , Brian Morrow , S. Motley , Alejandro Santillan , Karen Shaw , Kimberly Schwarz , Liu Tang , Hariharan Venkatesan , John Wiener
发明人: Brett Allison , Laurent Gomez , Cheryl Grice , Michael Hack , Brian Morrow , S. Motley , Alejandro Santillan , Karen Shaw , Kimberly Schwarz , Liu Tang , Hariharan Venkatesan , John Wiener
IPC分类号: A61K31/498 , A61K31/4745 , C07D487/02 , C07D471/02
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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14.Triptolide analogs for the treatment of autoimmune and inflammatory disorders 有权
标题翻译: 雷公藤内酯类似物用于治疗自身免疫性和炎症性疾病公开(公告)号:US08193249B2
公开(公告)日:2012-06-05
申请号:US12474305
申请日:2009-05-29
IPC分类号: C07D303/00 , A61K31/122
CPC分类号: C07D303/04 , C07C37/002 , C07C45/46 , C07C2601/14 , C07D303/14 , C07D303/32 , C07D493/10 , C07C47/565 , C07C39/11 , C07C39/17
摘要: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
摘要翻译: 本发明提供用于治疗自身免疫和抗炎症病症的合成方法和组合物,包括单独给药有效量的雷公藤内酯衍生物或与其他抗自身免疫或抗炎化合物组合或替代。
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公开(公告)号:US20050119245A1
公开(公告)日:2005-06-02
申请号:US10976067
申请日:2004-10-28
IPC分类号: C07C275/28 , C07C275/36 , C07C279/28 , C07D213/56 , C07D277/30 , C07D295/13 , C07D333/20 , C07D333/24 , C07K5/06 , A61K31/55 , A61K31/165 , A61K31/381 , A61K31/421 , A61K31/426 , A61K31/4439 , A61K31/454
CPC分类号: C07D295/13 , C07C275/28 , C07C275/36 , C07C279/28 , C07D213/56 , C07D277/30 , C07D333/20 , C07D333/24
摘要: Certain α-, β-, and γ-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain.
摘要翻译: 公开了某些α-,β-和γ-氨基酸衍生物作为选择性GlyT2抑制剂用于治疗中枢神经系统(CNS)病症如肌肉痉挛,耳鸣,癫痫和神经性疼痛。
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16.Triptolide analogs for the treatment of autoimmune and inflammatory disorders 有权
标题翻译: 雷公藤内酯类似物用于治疗自身免疫性和炎症性疾病公开(公告)号:US06777441B2
公开(公告)日:2004-08-17
申请号:US09970089
申请日:2001-10-02
IPC分类号: C07D31172
CPC分类号: C07D303/04 , C07C37/002 , C07C45/46 , C07C2601/14 , C07D303/14 , C07D303/32 , C07D493/10 , C07C47/565 , C07C39/11 , C07C39/17
摘要: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
摘要翻译: 本发明提供用于治疗自身免疫和抗炎症病症的合成方法和组合物,包括单独给药有效量的雷公藤内酯衍生物或与其他抗自身免疫或抗炎化合物组合或替代。
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公开(公告)号:US08242275B2
公开(公告)日:2012-08-14
申请号:US12833621
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号: C07D471/02
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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公开(公告)号:US20100274004A1
公开(公告)日:2010-10-28
申请号:US12833682
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
IPC分类号: C07D487/04 , C07D471/04 , C07D417/14 , C07D403/14 , C07D498/04
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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19.Triptolide Analogs for the Treatment of Autoimmune and Inflammatory Disorders 有权
标题翻译: 雷公藤内酯类似物治疗自身免疫性和炎性疾病公开(公告)号:US20090234000A1
公开(公告)日:2009-09-17
申请号:US12474305
申请日:2009-05-29
IPC分类号: A61K31/336 , C07D303/12
CPC分类号: C07D303/04 , C07C37/002 , C07C45/46 , C07C2601/14 , C07D303/14 , C07D303/32 , C07D493/10 , C07C47/565 , C07C39/11 , C07C39/17
摘要: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
摘要翻译: 本发明提供用于治疗自身免疫和抗炎症病症的合成方法和组合物,包括单独给药有效量的雷公藤内酯衍生物或与其他抗自身免疫或抗炎化合物组合或替代。
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公开(公告)号:US20060069286A1
公开(公告)日:2006-03-30
申请号:US11230249
申请日:2005-09-19
IPC分类号: C07C311/37
CPC分类号: C07D263/56 , C07C311/21 , C07D241/42 , C07D277/62 , C07D285/14 , C07D317/62 , C07D409/12 , C07D417/12
摘要: Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.
摘要翻译: 某些磺酰胺化合物是可用于治疗CCK1 / CCK2介导的疾病的双CCK1 / CCK2抑制剂。
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