-
公开(公告)号：US07271252B2
公开(公告)日：2007-09-18
申请号：US10420196
申请日：2003-04-22
申请人： Gerald F. Sigler , Mitali Ghoshal , Lili Arabshahi
发明人： Gerald F. Sigler , Mitali Ghoshal , Lili Arabshahi
CPC分类号： C07D265/18 , A61K47/643 , A61K47/646 , C07K16/44
摘要： The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz.
摘要翻译： 本发明提供依法韦仑的衍生物和依法韦仑衍生物的制备方法。 衍生物包括用于产生依法韦仑和标记的依法韦仑示踪剂抗体的免疫原性化合物。 这些化合物可用于确定依法韦仑的免疫测定方法。
-
公开(公告)号：US07649085B2
公开(公告)日：2010-01-19
申请号：US11420502
申请日：2006-05-26
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Erasmus Huber , Herbert W. Von Der Eltz
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Erasmus Huber , Herbert W. Von Der Eltz
IPC分类号： C07K17/06 , C07K1/10 , C07K16/00 , G01N33/532 , C07D277/04
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
-
公开(公告)号：US5525474A
公开(公告)日：1996-06-11
申请号：US190348
申请日：1994-01-31
IPC分类号： G01N33/53 , A61K39/385 , C07D211/60 , C07D211/62 , C07D401/12 , C07K14/47 , C07K16/44 , C08B37/00 , C12N9/96 , G01N33/531 , G01N33/542 , G01N33/577 , G01N33/94 , C07D207/273
CPC分类号： C07D401/12 , C07D211/62 , C07K16/44 , C12N9/96 , G01N33/531 , G01N33/9453 , Y10S436/815
摘要： Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: ##STR1## wherein: X=hydrogen or acetyl;n=1 to p where p=MW of Z/1000;Z=a poly(amino acid) or polysaccharide; andR3=a bond or ##STR2## wherein R2=an alkyl, cycloalkyl or aryl group having 2 to 10 carbon atoms. The derivatives include maleimide conjugates of proteins or poly(amino acids), enzymes, enzyme donor polypeptides and labeling substances. Novel activated hapten intermediates useful in the preparation of the conjugates and methods for synthesis of the hapten intermediates and derivatives are also disclosed.
摘要翻译： 公开了普鲁卡酰胺和N-乙酰丙酰胺（NAPA）的新型衍生物，其具有下式：其中：X =氢或乙酰基; n = 1〜p其中p = MW / Z; Z =聚（氨基酸）或多糖; 并且R3 = 2-10个碳原子的键或
。 衍生物包括蛋白质或聚（氨基酸）的马来酰亚胺缀合物，酶，酶供体多肽和标记物质。 还公开了可用于制备缀合物的新型活化的半抗原中间体和用于合成半抗原中间体和衍生物的方法。 -
公开(公告)号：US5439798A
公开(公告)日：1995-08-08
申请号：US169851
申请日：1993-12-17
申请人： Gerald F. Sigler , Charles F. Walter , Charles E. Durant , Todd Glancy , Frank E. Klein , Allan R. Dorn
发明人： Gerald F. Sigler , Charles F. Walter , Charles E. Durant , Todd Glancy , Frank E. Klein , Allan R. Dorn
IPC分类号： A61K39/385 , A61K39/395 , C07D207/40 , C07D207/416 , C07D207/44 , C07D207/452 , C07K16/44 , C08B37/00 , C12N9/38 , C12N9/96 , G01N33/542 , C07D207/448
CPC分类号： C07D207/416 , C07D207/452 , C07K16/44 , C12N9/2471 , C12N9/96 , C12Y302/01023 , Y10S436/822
摘要： Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: ##STR1## wherein: X=hydrogen or acetyl;R.sub.1 =an alkyl group having 1 to 3 carbon atoms;m=an integer from 2 to 10;R.sub.2 =an alkyl, cycloalkyl or aryl group having 2 to 10 carbon atoms;Z=a poly(amino acid); andn=1 to p where p=MW of Z/1000.The derivatives include maleimide conjugates of proteins or poly(amino acids), enzymes, enzyme donor polypeptides and labeling substances. Novel activated hapten intermediates useful in the preparation of the conjugates and methods for synthesis of the hapten intermediates and derivatives are also disclosed.
摘要翻译： 公开了普鲁卡因酰胺和N-乙酰丙酰胺（NAPA）的新型衍生物，其具有下式：其中：X =氢或乙酰基; R1 =具有1至3个碳原子的烷基; m = 2〜10的整数; R2 =具有2-10个碳原子的烷基，环烷基或芳基; Z =聚（氨基酸）; 并且n = 1到p，其中p = Z / 1000的MW。 衍生物包括蛋白质或聚（氨基酸）的马来酰亚胺缀合物，酶，酶供体多肽和标记物质。 还公开了可用于制备缀合物的新型活化的半抗原中间体和用于合成半抗原中间体和衍生物的方法。
-
公开(公告)号：US4794082A
公开(公告)日：1988-12-27
申请号：US92739
申请日：1987-09-03
申请人： Gerald F. Sigler
发明人： Gerald F. Sigler
IPC分类号： C07D495/04 , C07K15/00 , C07K17/02 , C07K17/06
CPC分类号： C07D495/04 , Y10S435/849
摘要： Compounds having a dithiopyridyl moiety linked to a biotin moiety are useful as thiol specific biotinylating agents. The biotin label can be cleaved in a reducing environment to yield the native thiol.
摘要翻译： 具有与生物素部分连接的二硫代吡啶基部分的化合物可用作硫醇特异性生物素化剂。 生物素标记可以在还原环境中裂解，得到天然硫醇。
-
公开(公告)号：US5336621A
公开(公告)日：1994-08-09
申请号：US211940
申请日：1988-06-27
IPC分类号： G01N33/531 , G01N33/543 , G01N33/78 , G01N33/94 , G01N33/546
CPC分类号： G01N33/531 , G01N33/536 , G01N33/543 , G01N33/54313 , G01N33/78 , G01N33/94 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 or 4; Y is independently --CONH--, --NHCO--, --OOC, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom, useful for the determination of haptens by immunochemical techniques are disclosed.
摘要翻译： 二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数 从2或4; Y独立地为-CONH-，-NHCO-，-OOC，-COO - ， - O - ， - S - 或-NR-，其中R为氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分，其用于通过免疫化学技术测定半抗原。
-
公开(公告)号：US5320954A
公开(公告)日：1994-06-14
申请号：US937255
申请日：1992-09-03
CPC分类号： C07H15/203 , C12P19/14 , C12P19/18 , C12P19/44 , C12Q1/40 , C12Q2334/00 , C12Q2334/10
摘要： An aromatic substituted glycoside is disclosed of the formula ##STR1## wherein the configuration of the substituted --OR on the anomeric carbon is alpha, n is an integer of 0 or 1, and R is a substituted aromatic radical selected from the group ##STR2## where R.sub.1 through R.sub.6 are independently halogen, NO.sub.2, SO.sub.3 H, COR.sub.7, ##STR3## where R.sub.7 is lower alkyl; and includes its stereoisomers, optical isomers and geometric isomers and mixtures of the foregoing isomers. These substrates are useful as direct substrates for alpha-amylases. A process for the preparation of the substrates and related substances is also described.
摘要翻译： 公开了芳族取代的糖苷，其具有式“IMAGE”，其中在端基异碳上的取代的-OR的构型是α，n是0或1的整数，R是选自下组的取代的芳族基团： （a）其中R 1至R 6独立地为卤素，NO 2，SO 3 H，COR 7，其中R 7为低级烷基;（b）和（c） 并包括其立体异构体，光学异构体和几何异构体以及前述异构体的混合物。 这些底物可用作α-淀粉酶的直接底物。 还描述了制备基底和相关物质的方法。
-
18.发明授权Reagent system for an alpha-amylase assay containing aromatic substituted glycoside 失效含有芳香取代糖苷的α-淀粉酶测定试剂系统
公开(公告)号：US4963479A
公开(公告)日：1990-10-16
申请号：US091861
申请日：1987-09-04
IPC分类号： C12P19/14 , C07H15/203 , C12P19/18 , C12P19/44 , C12Q1/40
CPC分类号： C07H15/203 , C12P19/14 , C12P19/18 , C12P19/44 , C12Q1/40 , C12Q2334/00 , C12Q2334/10
摘要： An aromatic substituted glycoside is disclosed of the formula ##STR1## wherein the configuration of the substituted --OR on the anomeric carbon is alpha, n is an integer of 0 to 1, and R is a substituted aromatic radical selected from the group ##STR2## where R.sub.1 through R.sub.6 are independently halogen, NO.sub.2, SO.sub.3 H, ##STR3## where R.sub.7 is lower alkyl; and includes its stereoisomers, optical isomers and geometric isomers and mixtures of the foregoing isomers. These substrates are useful as direct substrates for alpha-amylases. A process for the preparation of the substrates and related substances is also described.
-
公开(公告)号：US4798795A
公开(公告)日：1989-01-17
申请号：US092783
申请日：1987-09-03
申请人： Gerald F. Sigler
发明人： Gerald F. Sigler
IPC分类号： C07D495/04 , C07K15/00 , C07K17/02 , C07K17/06
CPC分类号： C07D495/04 , Y10S435/849 , Y10S530/812
摘要： Compounds having a dithiopyridyl moiety linked to a biotin moiety are useful as thiol specific biotinylating agents. The biotin label can be cleaved in a reducing environment to yield the native thiol.
摘要翻译： 具有与生物素部分连接的二硫代吡啶基部分的化合物可用作硫醇特异性生物素化剂。 生物素标记可以在还原环境中裂解，得到天然硫醇。
-
公开(公告)号：US4760142A
公开(公告)日：1988-07-26
申请号：US69747
申请日：1987-07-06
IPC分类号： G01N33/531 , G01N33/543 , G01N33/78 , G01N33/94 , C07D239/72
CPC分类号： G01N33/531 , G01N33/536 , G01N33/543 , G01N33/54313 , G01N33/78 , G01N33/94 , Y10S436/815 , Y10S436/816 , Y10S436/822 , Y10S436/823
摘要： Divalent hapten derivatives wherein two hapten moieties are connected by means of a bifunctional spacer wherein the derivative has the formulaA--X--Awhere A is a bonded hapten moiety and X is a bifunctional spacer having the formula(B).sub.m --Y--(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n --Y--(B).sub.mwhere m is independently 0 or 1, B is (CH.sub.2).sub.n', wherein n' is an integer from 1 to 4, or CO(CH.sub.2).sub.n", wherein n" is an integer from 2 to 4; Y is independently --CONH--, NHCO--, OOC--, --COO--, --O--, --S--, or --NR--, wherein R is hydrogen or alkyl; n is an integer from 1 to 10; and Z is an organic moiety containing at least one hydrophilic atom are disclosed.
摘要翻译： 二价半抗原衍生物，其中两个半抗原部分通过双官能间隔基连接，其中衍生物具有式AXA，其中A是键合半抗原部分，X是具有式（B）的双官能间隔基mY-（CH2）nZ-（CH2 ）nY-（B）m其中m独立地为0或1，B为（CH 2）n'，其中n'为1至4的整数，或CO（CH 2）n“，其中n”为整数 从2到4; Y独立地是-CONH-，NHCO-，OOC-，-COO-，-O - ， - S - 或-NR-，其中R是氢或烷基; n是1至10的整数; 并且Z是含有至少一个亲水性原子的有机部分。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.029 秒)
