公开(公告)号：US20240207411A1

公开(公告)日：2024-06-27

申请号：US18425761

申请日：2024-01-29

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Ketki Karanam ,  James Tendai Mutamba ,  Rishab R. Shyam ,  Jamie Simpson ,  Sifei Han ,  Luojuan Hu ,  Christopher John Hamilton Porter ,  Tim Quach ,  Natalie Trevaskis

IPC: A61K47/54 ,  A61K45/06

CPC classification number: A61K47/543 ,  A61K45/06

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20220143038A1

公开(公告)日：2022-05-12

申请号：US17586515

申请日：2022-01-27

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Ketki Karanam ,  Sifei Han ,  Luojuan Hu ,  Christopher John Hamilton Porter ,  Tim Quach ,  Rishab R. Shyam ,  Jamie Simpson ,  Natalie Trevaskis

IPC: A61K31/5377 ,  A61K47/54 ,  A61P37/06 ,  C07D413/12

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20170326103A1

公开(公告)日：2017-11-16

申请号：US15502757

申请日：2015-08-12

Applicant: Monash University

Inventor： Chris Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K31/365 ,  A61K31/568 ,  C07J7/00 ,  C07J1/00 ,  A61K31/4025 ,  B01J20/281 ,  C07J5/00 ,  A61K45/06 ,  A61K31/40 ,  C07J9/00 ,  C07J31/00 ,  G01N30/00

CPC classification number: A61K31/365 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/568 ,  A61K45/06 ,  A61P5/24 ,  C07J1/0025 ,  C07J1/0029 ,  C07J5/00 ,  C07J7/002 ,  C07J9/00 ,  C07J31/00 ,  C07J31/006 ,  C09J5/00 ,  G01N30/48 ,  G01N2030/486 ,  A61K2300/00

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

公开(公告)号：US20240050573A1

公开(公告)日：2024-02-15

申请号：US18343554

申请日：2023-06-28

Applicant: Monash University

Inventor： Christopher John Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K47/54 ,  A61K31/568 ,  A61K31/27 ,  A61K31/365 ,  A61K31/485 ,  C07C219/06 ,  C07C235/36 ,  C07D307/88 ,  A61K31/222 ,  C07C271/24 ,  C07D489/12 ,  C07J1/00 ,  A61K31/165 ,  A61K9/00 ,  A61K31/138 ,  A61K31/167 ,  A61K45/06

CPC classification number: A61K47/542 ,  A61K31/568 ,  A61K31/27 ,  A61K31/365 ,  A61K31/485 ,  C07C219/06 ,  C07C235/36 ,  C07D307/88 ,  A61K31/222 ,  C07C271/24 ,  C07D489/12 ,  C07J1/0029 ,  A61K31/165 ,  C07J1/0025 ,  A61K9/0053 ,  A61K31/138 ,  A61K31/167 ,  A61K45/06 ,  C07C2602/26

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

公开(公告)号：US20230338552A1

公开(公告)日：2023-10-26

申请号：US18341519

申请日：2023-06-26

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Rishab R. Shyam ,  Jamie Simpson ,  Christopher John Porter ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K47/55 ,  A61K31/573 ,  A61K9/00 ,  A61K47/54

CPC classification number: A61K47/55 ,  A61K31/573 ,  A61K9/0053 ,  A61K47/542

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US11608345B1

公开(公告)日：2023-03-21

申请号：US16955084

申请日：2018-12-19

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Sifei Han ,  Luojuan Hu ,  Ketki Karanam ,  Christopher John Porter ,  Tim Quach ,  Rishab R. Shyam ,  Jamie Simpson ,  Natalie Trevaskis

IPC: C07D498/18 ,  A61P37/06

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US20220211664A1

公开(公告)日：2022-07-07

申请号：US17697694

申请日：2022-03-17

Applicant: Monash University

Inventor： Chris Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K31/365 ,  A61K31/568 ,  C07J1/00 ,  C07J7/00 ,  C07J31/00 ,  A61K45/06 ,  A61K31/40 ,  A61K31/4025 ,  A61P5/24 ,  B01J20/281

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

公开(公告)号：US20190105299A1

公开(公告)日：2019-04-11

申请号：US16209600

申请日：2018-12-04

Applicant: Monash University

Inventor： Christopher John Hamilton Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K31/365 ,  A61K31/568 ,  A61K31/4025 ,  A61K45/06 ,  C07J31/00 ,  C07J7/00 ,  C07J1/00 ,  A61P5/24 ,  A61K31/40 ,  B01J20/281 ,  C07J9/00 ,  G01N30/00 ,  C09J5/00

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.