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    PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES
    17.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES 有权
    包含百里香醇衍生物的药物组合物

    公开(公告)号：US20160304528A1

    公开(公告)日：2016-10-20

    申请号：US15192126

    申请日：2016-06-24

    Applicant: NEONC TECHNOLOGIES INC.

    Inventor： Thomas Chen ,  Daniel Levin ,  Satish Pupalli

    IPC: C07D487/04 ,  C07D231/12

    CPC classification number: C07D487/04 ,  C07D231/12

    Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

    Abstract translation: 提供一种药物组合物，其包含与治疗剂缀合的紫苏醇，并​​且还包括可水解的酰化脂肪族尾巴。 还提供使用该药物组合物的方法来治疗患者的病症或疾病，例如癌症。

    Pharmaceutical compositions comprising monoterpenes
    18.
    发明授权
    Pharmaceutical compositions comprising monoterpenes 有权
    包含单萜的药物组合物

    公开(公告)号：US09133085B2

    公开(公告)日：2015-09-15

    申请号：US13939834

    申请日：2013-07-11

    Applicant: Neonc Technologies, Inc.

    Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

    IPC: C07C35/18 ,  C07C29/78 ,  A61K31/045 ,  C07C29/92 ,  C07C67/14 ,  C07C201/12

    CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07B2200/07 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07C2601/16 ,  C07C33/14 ,  C07C205/57 ,  C07C69/76 ,  C07C69/92

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

    Abstract translation: 本发明提供纯化大于约98.5％（w / w）的单萜或倍半萜的方法。 该方法包括衍生单萜（或倍半萜烯）以产生单萜（或倍半萜烯）衍生物，分离单萜（或倍半萜烯）衍生物和从衍生物中释放单萜（或倍半萜烯）的步骤。 包括本发明范围的药物组合物是包含纯度大于约98.5％（w / w）的单萜（或倍半萜烯）的药物组合物。 纯化的单萜可用于治疗癌症等疾病。 本单萜（或倍半萜烯）可以单独施用，或者可以与辐射或其它治疗剂如化学治疗剂共同施用。

    Pharmaceutical compositions comprising monoterpenes
    20.
    发明授权
    Pharmaceutical compositions comprising monoterpenes 有权

    公开(公告)号：US10457618B2

    公开(公告)日：2019-10-29

    申请号：US15220135

    申请日：2016-07-26

    Applicant: NEONC Technologies, Inc.

    Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

    IPC: C07C29/92 ,  A61K31/045 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

    Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

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