公开(公告)号：US20150348287A1

公开(公告)日：2015-12-03

申请号：US14698641

申请日：2015-04-28

Applicant: Northwestern University

Inventor： Ji Yi ,  Wenzhong Liu ,  Vadim Backman ,  Hao F. Zhang

IPC: G06T11/00 ,  G06T7/00 ,  G06F17/10

CPC classification number: A61B3/102 ,  A61B1/04 ,  A61B3/1233 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  G01B9/02091 ,  G06F17/10 ,  G06F17/13 ,  G06T7/0012 ,  G06T7/0014 ,  G06T11/003 ,  G06T2207/10028 ,  G06T2207/10101

Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

Abstract translation: 本公开提供了使用非侵入性非接触成像技术（例如OCT）来确定靶中一种或多种分析物浓度的变化速率的系统和方法。 通常，获取OCT数据，并从OCT扫描中提取光学信息，以定量地确定靶中的流体流速和一种或多种分析物的浓度。 两种计算都可以提供一种方法来确定分析物随时间变化的速度。 本公开的示例性方法和系统可用于评估组织的代谢，其中氧是所检测的分析物或其它功能状态，并且通常用于诊断，监测和治疗疾病。

公开(公告)号：US09962075B2

公开(公告)日：2018-05-08

申请号：US15465285

申请日：2017-03-21

Applicant: Northwestern University

Inventor： Ji Yi ,  Wenzhong Liu ,  Vadim Backman ,  Hao F. Zhang ,  Kieren J. Patel

IPC: G06K9/00 ,  A61B3/10 ,  G06T7/00 ,  G01B9/02 ,  A61B5/1455 ,  A61B3/12 ,  A61B5/145 ,  A61B5/0205 ,  A61B1/04 ,  G06F17/13 ,  A61B5/00 ,  A61B5/026

CPC classification number: A61B3/102 ,  A61B1/04 ,  A61B3/1233 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  G01B9/02091 ,  G06F17/10 ,  G06F17/13 ,  G06T7/0012 ,  G06T7/0014 ,  G06T11/003 ,  G06T2207/10028 ,  G06T2207/10101

Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

公开(公告)号：US20180017487A1

公开(公告)日：2018-01-18

申请号：US15590745

申请日：2017-05-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Vadim Backman ,  Ji Yi

IPC: G01N21/47 ,  A61B5/00

CPC classification number: G01N21/4795 ,  A61B5/0066

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

公开(公告)号：US20170188818A1

公开(公告)日：2017-07-06

申请号：US15465285

申请日：2017-03-21

Applicant: Northwestern University

Inventor： Ji Yi ,  Wenzhong Liu ,  Vadim Backman ,  Hao F. Zhang ,  Kieren J. Patel

IPC: A61B3/10 ,  G01B9/02 ,  A61B5/1455 ,  G06F17/13 ,  A61B5/145 ,  A61B5/0205 ,  A61B1/04 ,  G06T7/00 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B1/04 ,  A61B3/1233 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  G01B9/02091 ,  G06F17/10 ,  G06F17/13 ,  G06T7/0012 ,  G06T7/0014 ,  G06T11/003 ,  G06T2207/10028 ,  G06T2207/10101

Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.