公开(公告)号：US09678007B2

公开(公告)日：2017-06-13

申请号：US13651196

申请日：2012-10-12

Applicant: Northwestern University

Inventor： Vadim Backman ,  Ji Yi

IPC: G06K9/00 ,  G01N21/47 ,  A61B5/00

CPC classification number: G01N21/4795 ,  A61B5/0066

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the backscattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

公开(公告)号：US20130095519A1

公开(公告)日：2013-04-18

申请号：US13651196

申请日：2012-10-12

Applicant: Northwestern University

Inventor： Vadim Backman ,  Ji Yi

IPC: G01N21/45 ,  A61B6/00 ,  G06K9/36

CPC classification number: G01N21/4795 ,  A61B5/0066

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio of scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

Abstract translation: 公开了通过逆光谱光学相干断层扫描（ISOCT）测量和成像全部光散射特性的方法和系统。 组织被建模为具有连续折射率（RI）波动的介质，并且这种波动由RI相关函数描述。 通过测量组织的光学量（包括OCT光谱的散射功率，被定义为散射系数μ的比率的反射反照率α和背散射系数mub），RI相关函数可以被逆推并且全集 的光散射特性。

公开(公告)号：US20190008965A1

公开(公告)日：2019-01-10

申请号：US16030765

申请日：2018-07-09

Applicant: Northwestern University

Inventor： Phillip B. Messersmith ,  Kvar C.L. Black ,  Ji Yi ,  Jose G. Rivera

IPC: A61K41/00 ,  G01N33/58 ,  A61K47/69 ,  G01N33/543 ,  G01N21/552 ,  G01N21/47 ,  C07K16/30 ,  C07K16/28 ,  C07K16/00 ,  B82Y40/00 ,  G01N33/553 ,  B82Y5/00 ,  A61N5/06 ,  A61K49/18 ,  A61K45/06 ,  A61K39/40 ,  A61K39/395 ,  A61K33/38 ,  A61K33/26 ,  A61K33/00 ,  A61K31/69 ,  A61K9/51 ,  A61K9/50 ,  A61K9/16 ,  A61K9/00 ,  B82Y15/00

Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.

公开(公告)号：US20160228549A1

公开(公告)日：2016-08-11

申请号：US15098063

申请日：2016-04-13

Applicant: Northwestern University

Inventor： Phillip B. Messersmith ,  Kvar C.L. Black ,  Ji Yi ,  Jose G. Rivera

IPC: A61K41/00 ,  A61K49/18 ,  A61N5/06 ,  C07K16/30 ,  G01N33/543 ,  G01N33/553 ,  A61K9/16 ,  C07K16/28

CPC classification number: A61K41/0052 ,  A61K9/0092 ,  A61K9/1611 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/1682 ,  A61K9/5094 ,  A61K9/51 ,  A61K31/69 ,  A61K33/00 ,  A61K33/26 ,  A61K33/38 ,  A61K39/39558 ,  A61K39/40 ,  A61K41/0057 ,  A61K45/06 ,  A61K47/6923 ,  A61K49/1857 ,  A61K49/1875 ,  A61N5/062 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/30 ,  G01N21/4795 ,  G01N21/554 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/587

Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.

Abstract translation: 本发明提供纳米颗粒，其包括金属芯，每个轴的长度为1至100纳米，涂层设置在金属芯的至少部分表面上，其中涂层包括聚多巴胺以及制备和使用方法 这样的纳米颗粒。 金属芯可以是金，银或氧化铁，并且聚多巴胺涂层可以具有与其结合的其它物质，例如银，靶向配体或抗体，或其它治疗或成像造影剂。 所公开的纳米颗粒可以靶向用于治疗癌症或细菌感染的细胞，并用于诊断成像。

公开(公告)号：US20180256025A1

公开(公告)日：2018-09-13

申请号：US15972753

申请日：2018-05-07

Applicant: Northwestern University

Inventor： Ji Yi ,  Wenzhong Liu ,  Vadim Backman ,  Hao F. Zhang ,  Kieren J. Patel

IPC: A61B3/10 ,  G06T7/00 ,  A61B5/1455 ,  A61B3/12 ,  A61B5/145 ,  A61B5/0205 ,  A61B1/04 ,  G06F17/13

CPC classification number: A61B3/102 ,  A61B1/04 ,  A61B3/1233 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  G01B9/02091 ,  G06F17/10 ,  G06F17/13 ,  G06T7/0012 ,  G06T7/0014 ,  G06T11/003 ,  G06T2207/10028 ,  G06T2207/10101

Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

公开(公告)号：US09619903B2

公开(公告)日：2017-04-11

申请号：US14698641

申请日：2015-04-28

Applicant: Northwestern University

Inventor： Ji Yi ,  Wenzhong Liu ,  Vadim Backman ,  Hao F. Zhang

IPC: G06K9/00 ,  G06T11/00 ,  G06F17/10 ,  G06T7/00 ,  A61B3/10 ,  A61B3/12 ,  A61B5/00 ,  A61B5/026

CPC classification number: A61B3/102 ,  A61B1/04 ,  A61B3/1233 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0205 ,  A61B5/0261 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  G01B9/02091 ,  G06F17/10 ,  G06F17/13 ,  G06T7/0012 ,  G06T7/0014 ,  G06T11/003 ,  G06T2207/10028 ,  G06T2207/10101

Abstract: The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

公开(公告)号：US09360660B2

公开(公告)日：2016-06-07

申请号：US13902288

申请日：2013-05-24

Applicant: Northwestern University

Inventor： Ji Yi ,  Vadim Backman ,  Qing Wei ,  Hao F. Zhang

IPC: G02B21/06 ,  G02B21/00 ,  G01N21/64 ,  G01B9/02 ,  G01N21/45 ,  G01N21/47 ,  G01N21/17

CPC classification number: G02B21/0032 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01N21/45 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6458 ,  G01N2021/1787 ,  G01N2021/456 ,  G01N2201/067 ,  G01N2201/0691

Abstract: Certain examples provide a structured illumination microscopy system. The example system includes a laser source to generate excitation illumination directed toward a target. The example system includes a modulator to modulate the excitation illumination temporally in a controllable spatial pattern to be constructed on the target object to provide sub-diffractional resolution in a lateral direction with respect to the target. The example system includes two synchronized laser scanning mirror units in confocal arrangement, the laser scanning units to be synchronized and controlled by a computing device, a first of the scanning mirror units to receive the modulated excitation illumination and project the modulated excitation illumination on the target object and a second of the scanning mirror units to receive emission fluorescence from the target and project the emission fluorescence. The example system includes a detector to collect emission fluorescence from the target via the second of the scanning mirror units.

Abstract translation: 某些实例提供了结构化的照明显微镜系统。 该示例系统包括产生朝向目标的激发照明的激光源。 该示例系统包括一个调制器，用于以可控的空间图案临时调制激励照明，以在目标物体上构造，以在相对于目标的横向方向上提供子衍射分辨率。 示例系统包括共焦排列的两个同步的激光扫描镜单元，由计算装置同步和控制的激光扫描单元，用于接收经调制的激发照明并将调制的激发照明投影到目标上的第一扫描镜单元 物体和第二个扫描镜单元，以从目标接收发射荧光并投射发射荧光。 该示例系统包括用于经由第二扫描反射镜单元从目标物体收集发射荧光的检测器。

公开(公告)号：US20130314717A1

公开(公告)日：2013-11-28

申请号：US13902288

申请日：2013-05-24

Applicant: Northwestern University

Inventor： Ji Yi ,  Vadim Backman ,  Qing Wei ,  Hao F. Zhang

IPC: G02B21/00 ,  G01B9/02 ,  G01N21/64

CPC classification number: G02B21/0032 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01N21/45 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6458 ,  G01N2021/1787 ,  G01N2021/456 ,  G01N2201/067 ,  G01N2201/0691

Abstract: Certain examples provide a structured illumination microscopy system. The example system includes a laser source to generate excitation illumination directed toward a target. The example system includes a modulator to modulate the excitation illumination temporally in a controllable spatial pattern to be constructed on the target object to provide sub-diffractional resolution in a lateral direction with respect to the target. The example system includes two synchronized laser scanning mirror units in confocal arrangement, the laser scanning units to be synchronized and controlled by a computing device, a first of the scanning mirror units to receive the modulated excitation illumination and project the modulated excitation illumination on the target object and a second of the scanning mirror units to receive emission fluorescence from the target and project the emission fluorescence. The example system includes a detector to collect emission fluorescence from the target via the second of the scanning mirror units.

Abstract translation: 某些实例提供了结构化的照明显微镜系统。 该示例系统包括产生朝向目标的激发照明的激光源。 该示例系统包括一个调制器，用于以可控的空间图案临时调制激励照明，以在目标物体上构造，以在相对于目标的横向方向上提供子衍射分辨率。 示例系统包括共焦排列的两个同步的激光扫描镜单元，由计算装置同步和控制的激光扫描单元，用于接收经调制的激发照明并将调制的激发照明投影到目标上的第一扫描镜单元 物体和第二个扫描镜单元，以从目标接收发射荧光并投射发射荧光。 该示例系统包括用于经由第二扫描反射镜单元从目标物体收集发射荧光的检测器。

公开(公告)号：US10241041B2

公开(公告)日：2019-03-26

申请号：US15590745

申请日：2017-05-09

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Vadim Backman ,  Ji Yi

IPC: G06K9/00 ,  G01N21/47 ,  A61B5/00

Abstract: A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo α defined as the ratio or scattering coefficient μs, and the back-scattering coefficient μb), the RI correlation function can be inversely deduced and the full set of optical scattering properties can be obtained.

公开(公告)号：US10016499B2

公开(公告)日：2018-07-10

申请号：US15098063

申请日：2016-04-13

Applicant: Northwestern University

Inventor： Phillip B. Messersmith ,  Kvar C. L. Black ,  Ji Yi ,  Jose G. Rivera

IPC: A61K41/00 ,  A61K49/18 ,  A61N5/06 ,  C07K16/30 ,  G01N33/543 ,  G01N33/553 ,  A61K9/16 ,  A61K9/00 ,  A61K9/50 ,  B82Y5/00 ,  C07K16/00 ,  G01N21/47 ,  G01N21/552 ,  A61K31/69 ,  A61K33/00 ,  B82Y40/00 ,  A61K45/06 ,  A61K33/26 ,  A61K33/38 ,  A61K9/51 ,  A61K39/395 ,  A61K39/40 ,  G01N33/58 ,  C07K16/28 ,  A61K47/69 ,  B82Y15/00

CPC classification number: A61K41/0052 ,  A61K9/0092 ,  A61K9/1611 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/1682 ,  A61K9/5094 ,  A61K9/51 ,  A61K31/69 ,  A61K33/00 ,  A61K33/26 ,  A61K33/38 ,  A61K39/39558 ,  A61K39/40 ,  A61K41/0057 ,  A61K45/06 ,  A61K47/6923 ,  A61K49/1857 ,  A61K49/1875 ,  A61N5/062 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/30 ,  G01N21/4795 ,  G01N21/554 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/587

Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.