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公开(公告)号：US09403827B2
公开(公告)日：2016-08-02
申请号：US14762037
申请日：2014-01-21
申请人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Andrea Vaupel
发明人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Andrea Vaupel
IPC分类号： A61K31/522 , C07D473/28
CPC分类号： C07D473/28 , A61K31/522
摘要： The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of as MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译： 本发明涉及式（I）化合物：本文所述的（I）化合物，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM2的活性介导的病症或疾病的用途和用途的方法， 或MDM4，以及包含这些化合物的组合。
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公开(公告)号：US08859586B2
公开(公告)日：2014-10-14
申请号：US14127159
申请日：2012-06-19
申请人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号： C07D217/22 , A61K31/47 , A61K31/4725 , A61K31/472 , C07D405/08 , C07D401/08 , C07D217/24
CPC分类号： C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
摘要： The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译： 本发明涉及式（I）化合物：如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号：US08440693B2
公开(公告)日：2013-05-14
申请号：US12973474
申请日：2010-12-20
申请人： Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
发明人： Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
IPC分类号： A01N37/18 , A61K31/65 , C07D215/00
CPC分类号： C07D239/82 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译： 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号：US08969341B2
公开(公告)日：2015-03-03
申请号：US14361068
申请日：2012-11-28
申请人： Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
发明人： Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/505 , A61K31/4709 , A61K31/4523 , A61K31/4155 , C07D413/14 , C07D487/14 , C07D239/02 , C07D403/14 , C07D215/00 , C07D211/80 , C07D401/14 , C07D257/02 , C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506
CPC分类号： C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377
摘要： The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译： 本发明涉及本文所述的式（I）化合物，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的化合物的用途和用途，以及组合 包括这样的化合物。
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公开(公告)号：US20140275158A1
公开(公告)日：2014-09-18
申请号：US14127159
申请日：2012-06-19
申请人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号： C07D217/24 , C07D405/08 , A61K31/4725 , A61K31/472 , C07D401/08
CPC分类号： C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
摘要： The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译： 本发明涉及式（I）化合物：如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号：US20140135306A1
公开(公告)日：2014-05-15
申请号：US14127155
申请日：2012-06-19
申请人： Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人： Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号： C07D409/10 , A61K31/472 , C07D401/04 , A61K31/4725 , C07D401/10 , C07D405/10 , C07D405/14 , C07D217/24 , C07D401/14
CPC分类号： A61K31/4725 , A61K31/472 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/08 , C07D451/02 , C07D451/14 , C07D491/08 , C07D493/08
摘要： The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译： 本发明涉及式（I）化合物：如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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![Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors](/abs-image/US/2013/04/16/US08420657B2/abs.jpg.150x150.jpg)
17.发明授权Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors 失效吡咯并[2,3-D]嘧啶及其作为酪氨酸激酶抑制剂的用途公开(公告)号：US08420657B2
公开(公告)日：2013-04-16
申请号：US12366218
申请日：2009-02-05
IPC分类号： C07D487/04 , A61K31/519 , A61P35/02 , A61P37/06 , A61P35/04 , A61P25/28
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula I and salts thereof wherein the substituens are as defined in the specification, processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，其制备方法; 涉及含有这些化合物的药物，特别是用于一种或多种蛋白质酪氨酸激酶介导的疾病。
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18.发明授权Oxazine derivatives and their use in the treatment of neurological disorders 有权恶嗪衍生物及其在治疗神经系统疾病中的应用公开(公告)号：US08207164B2
公开(公告)日：2012-06-26
申请号：US12842360
申请日：2010-07-23
IPC分类号： A61K31/5377 , A61K31/5375 , C07D413/12 , C07D419/12 , C07D265/30 , A61P25/28
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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公开(公告)号：US20090203688A1
公开(公告)日：2009-08-13
申请号：US12366218
申请日：2009-02-05
IPC分类号： A61K31/5355 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula I and salts thereof wherein the substituents are as defined in the specification, processes for the preparation thereof; to pharmaceuticals containing such compounds, in particular for the use in one or more Protein tyrosine kinase mediated diseases.
摘要翻译： 本发明涉及式I化合物及其盐，其中取代基如说明书中所定义，其制备方法; 涉及含有这些化合物的药物，特别是用于一种或多种蛋白质酪氨酸激酶介导的疾病。
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公开(公告)号：US20140113894A1
公开(公告)日：2014-04-24
申请号：US14136679
申请日：2013-12-20
IPC分类号： C07D413/12
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
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