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1.发明授权Oxazine derivatives and their use in the treatment of neurological disorders 有权恶嗪衍生物及其在治疗神经系统疾病中的应用公开(公告)号：US08207164B2
公开(公告)日：2012-06-26
申请号：US12842360
申请日：2010-07-23
IPC分类号： A61K31/5377 , A61K31/5375 , C07D413/12 , C07D419/12 , C07D265/30 , A61P25/28
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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公开(公告)号：US20140113894A1
公开(公告)日：2014-04-24
申请号：US14136679
申请日：2013-12-20
IPC分类号： C07D413/12
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
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3.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20120302558A1
公开(公告)日：2012-11-29
申请号：US13255036
申请日：2011-07-13
申请人： Sangamesh Badiger , Murali Chebrolu , Mathias Frederiksen , Philipp Holzer , Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Ulf Neumann , Rita Ramos , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle , Lei Li , Hui Liu , Xin Xiong
发明人： Sangamesh Badiger , Murali Chebrolu , Mathias Frederiksen , Philipp Holzer , Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Ulf Neumann , Rita Ramos , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle , Lei Li , Hui Liu , Xin Xiong
IPC分类号： A61K31/5377 , A61P25/28 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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4.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20140088084A1
公开(公告)日：2014-03-27
申请号：US13940354
申请日：2013-07-12
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/553 , C07D417/12 , C07D413/14 , C07D413/12 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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公开(公告)号：US09284284B2
公开(公告)日：2016-03-15
申请号：US14350938
申请日：2012-10-11
申请人： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
发明人： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC分类号： C07D265/30 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , A61K31/5375 , A61K31/5377
CPC分类号： C07D265/30 , A61K31/5375 , A61K31/5377 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
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6.发明申请公开(公告)号：US20100056490A1
公开(公告)日：2010-03-04
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/397 , C07D401/12 , C07D205/02 , C07D335/02 , A61K31/4535 , A61K31/382 , A61P25/00 , A61P9/10
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
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公开(公告)号：US20090312370A1
公开(公告)日：2009-12-17
申请号：US12374467
申请日：2007-07-20
IPC分类号： A61K31/4439 , C07D211/70 , A61K31/44 , C07D413/12
CPC分类号： C07D273/00 , C07D245/06 , C07D273/02 , C07D401/12 , C07D413/12 , C07D413/14
摘要： The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物，其中所有变量如本说明书中所定义，游离碱形式或酸加成盐形式，其制备方法，用作药物和包含它们的药物。
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8.发明申请Oxazine Derivatives and their Use in the Treatment of Neurological Disorders 审中-公开恶嗪衍生物及其在神经障碍治疗中的应用公开(公告)号：US20130281449A1
公开(公告)日：2013-10-24
申请号：US13978885
申请日：2012-01-11
申请人： Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Ulf Neumann , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
发明人： Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Ulf Neumann , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC分类号： C07D413/12 , C07D471/04 , A61K45/06 , A61K31/5377
CPC分类号： C07D413/12 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D471/04
摘要： The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in pharmaceutically acceptable salt form, to their preparation, to their medical use and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或药学上可接受的盐形式，其制备方法及其医疗用途以及包含它们的药物 。
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公开(公告)号：US07612055B2
公开(公告)日：2009-11-03
申请号：US10577260
申请日：2004-11-04
申请人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
发明人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
IPC分类号： A01N43/00 , A61K31/33 , C07D245/00
CPC分类号： C07D245/02 , C07D255/00 , C07D273/00 , C07D281/00 , C07D471/08 , C07D513/08
摘要： The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物其中R1，R2，R3，U，V，W，X，Y，Z和n如说明书中所定义，大环中包括的环原子数为14 ，15,16或17，以游离碱形式或以酸加成盐形式，用于制备，用作药物和包含它们的药物组合物。
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公开(公告)号：US20140256715A1
公开(公告)日：2014-09-11
申请号：US14350938
申请日：2012-10-11
申请人： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
发明人： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC分类号： C07D265/30 , A61K31/5377 , C07D487/04 , A61K31/5375 , C07D471/04 , C07D417/12 , C07D413/12
CPC分类号： C07D265/30 , A61K31/5375 , A61K31/5377 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
摘要翻译： 本发明涉及式（I）的新的恶嗪衍生物及其药学上可接受的盐，其中所有变量如说明书，其药物组合物，其组合，及其作为药物的用途，特别是用于治疗 通过BACE-1或BACE-2的抑制来治疗阿尔茨海默病或糖尿病。
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