公开(公告)号：US20050038105A1

公开(公告)日：2005-02-17

申请号：US10491549

申请日：2002-10-02

申请人： Gilles Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

发明人： Gilles Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

IPC分类号： C07D311/90 ,  A61K31/17 ,  A61K31/352 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00 ,  C07C275/24 ,  C07C279/12 ,  C07C323/60 ,  C07D311/82 ,  A61K31/353 ,  A61K31/16 ,  A61K31/325

CPC分类号： C07C279/12 ,  C07C275/24 ,  C07C323/60 ,  C07D311/82

摘要： Compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra. The compounds are used for the preparation of medicaments that are intended to treat bacterial, fungal or cytotoxic diseases and, in particular, fungal infections, such as aspergillosis and candidiasis, and resistant bacterial infections.

摘要翻译： 具有通式X-（A）n-Y的化合物，其中：n在6和20之间变化; X表示氢原子，RaCO，RaOCO，RaNHCO或RaSO2基团，Ra是烷基，烯基，炔基，芳基，芳烷基，杂芳基，该基团被取代或未被取代，条件是当n为 等于6; A表示具有式（I）或（II）的基团，其中R 1是氢原子，氨基酸侧链，烷基，烯基，炔基，芳基，芳烷基或杂芳基，所述基团被取代， 是1和n之间的整数; Y是具有与先前对Ra相同的含义的NRbRc，Rb和Rc基团。 这些化合物用于制备用于治疗细菌，真菌或细胞毒性疾病，特别是真菌感染如曲霉病和念珠菌病以及抗性细菌感染的药物。

公开(公告)号：US08124743B2

公开(公告)日：2012-02-28

申请号：US12303089

申请日：2007-06-01

申请人： Vijay M. Krishnamurthy ,  Lara A. Estroff ,  Vincent Semetey ,  Samuel W. Thomas ,  George K. Kaufman ,  Zihni Basar Bilgicer ,  George M. Whitesides

发明人： Vijay M. Krishnamurthy ,  Lara A. Estroff ,  Vincent Semetey ,  Samuel W. Thomas ,  George K. Kaufman ,  Zihni Basar Bilgicer ,  George M. Whitesides

IPC分类号： C07K16/00 ,  C07K1/22 ,  C07K1/30

CPC分类号： C07K16/065 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/54 ,  Y10S436/822

摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.

摘要翻译： 本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到 可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。

公开(公告)号：US07741014B2

公开(公告)日：2010-06-22

申请号：US11401485

申请日：2006-04-10

申请人： Declan Ryan ,  Babak Amir-Parviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel K. Sia ,  George M. Whitesides

发明人： Declan Ryan ,  Babak Amir-Parviz ,  Vincent Linder ,  Vincent Semetey ,  Samuel K. Sia ,  George M. Whitesides

IPC分类号： G03F7/00 ,  H01L21/302

CPC分类号： G03F7/165 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B82Y5/00 ,  B82Y30/00 ,  C03C17/28 ,  C03C23/0005 ,  C03C2218/32 ,  C40B80/00 ,  G03F7/203

摘要： A series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation is provided. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface.

摘要翻译： 提供了一系列用于通过将分子暴露于电磁辐射来图案化具有多个对准的分子层的表面的方法，组合物和制品。 在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。 通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。 在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。

公开(公告)号：US07691899B2

公开(公告)日：2010-04-06

申请号：US10491549

申请日：2002-10-02

申请人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

发明人： Gilles Francois Roger Guichard ,  Jean-Paul Briand ,  Vincent Semetey ,  Patrick Neuberg

IPC分类号： A01N43/16 ,  A01N43/10 ,  A01N37/18

CPC分类号： C07C279/12 ,  C07C275/24 ,  C07C323/60 ,  C07D311/82

摘要： Compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition that X is different from H when n is equal to 6; A denotes either a group having formula (I) or (II), wherein Ri is a hydrogen atom, an amino acid side chain, an alkyl, alkenyl, alkynyl, aryl, aralkyl or heteroaryl group, said groups being substituted or not, i being an integer of between 1 and n; Y is an NRbRc, Rb and Rc group having the same meaning as given earlier for Ra. The compounds are used for the preparation of medicaments that are intended to treat bacterial, fungal or cytotoxic diseases and, in particular, fungal infections, such as aspergillosis and candidiasis, and resistant bacterial infections.

摘要翻译： 具有通式X-（A）n-Y的化合物，其中：n在6和20之间变化; X表示氢原子，RaCO，RaOCO，RaNHCO或RaSO2基团，Ra是烷基，烯基，炔基，芳基，芳烷基，杂芳基，该基团被取代或未被取代，条件是当n为 等于6; A表示具有式（I）或（II）的基团，其中R 1是氢原子，氨基酸侧链，烷基，烯基，炔基，芳基，芳烷基或杂芳基，所述基团被取代， 是1和n之间的整数; Y是具有与先前对Ra相同的含义的NRbRc，Rb和Rc基团。 这些化合物用于制备用于治疗细菌，真菌或细胞毒性疾病，特别是真菌感染如曲霉病和念珠菌病以及抗性细菌感染的药物。

公开(公告)号：US20050159584A1

公开(公告)日：2005-07-21

申请号：US11077257

申请日：2005-03-11

申请人： Gilles Guichard ,  Marc Rodriguez ,  Vincent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

发明人： Gilles Guichard ,  Marc Rodriguez ,  Vincent Semetey ,  Jean-Paul Briand ,  Marie-Christine Galas-Rodriguez ,  Pierre Rodriguez ,  Elisa Rodriguez ,  Romain Rodriguez

IPC分类号： C07D401/12 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4725 ,  A61P31/18 ,  A61P37/02 ,  A61P43/00 ,  C07C263/12 ,  C07C265/04 ,  C07C265/12 ,  C07C273/18 ,  C07C275/14 ,  C07C275/16 ,  C07C275/28 ,  C07D207/40 ,  C07D207/404 ,  C07D259/00 ,  C07D403/12 ,  C08G71/02 ,  C07K14/47 ,  C07K7/06

CPC分类号： C07D207/404 ,  C07C275/14 ,  C08G71/02

摘要： Process for the preparation of stable activated derivatives of carbamic acid, comprising at least one protected amino group and an activated carbamic acid function, from an amino acid derivative in which the amino group is protected. The process includes: a) a step of transformation of the —COOH group of the amino acid derivative into a —CON3 group to obtain an acyl azide; b) a step of transformation of the —CON3 group of the acyl azide into a —NCO group to obtain an isocyanate; c) a step of treating the isocyanate to obtain a stable derivative of carbamic acid.

摘要翻译： 由保护氨基的氨基酸衍生物制备稳定的氨基甲酸活化衍生物的方法，其包括至少一种被保护的氨基和活性的氨基甲酸功能。 该方法包括：a）将氨基酸衍生物的-COOH基团转化为-CON 3 N 3基团以获得酰基叠氮化物的步骤; b）将酰基叠氮化物的-CON 3 N 3基团转化为-NCO基团以获得异氰酸酯的步骤; c）处理异氰酸酯以获得稳定的氨基甲酸衍生物的步骤。