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11.发明授权mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US09180192B2
公开(公告)日：2015-11-10
申请号：US13503644
申请日：2010-10-22
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Rocco D. Gogliotti
IPC分类号： A61K31/4155 , C07D231/10 , C07D231/38 , C07D403/12 , A61K45/06 , A61K31/415 , A61K31/4439 , C07D231/40 , C07D401/12 , C07D417/12 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/40 , A61K31/4025 , A61K31/427 , A61K31/4709 , A61K31/506 , A61K31/538 , C07D207/48 , C07D405/12 , C07D413/14
CPC分类号： A61K45/06 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/538 , C07D207/48 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
摘要： Pyrazole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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12.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130040944A1
公开(公告)日：2013-02-14
申请号：US13503644
申请日：2010-10-22
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti
IPC分类号： A61K31/4025 , C07D401/12 , A61K31/4439 , C07D403/12 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/538 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/22 , A61P3/04 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/00 , C07D405/12
CPC分类号： A61K45/06 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/538 , C07D207/48 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
摘要： Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的吡咯化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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13.发明申请SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权替代二氯吡啶和二氧化吡咯烷酮作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20110124663A1
公开(公告)日：2011-05-26
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/506 , A61K31/4439 , C07D401/12 , A61K31/4725 , A61K31/438 , C07D403/12 , A61K31/427 , C07D417/12 , A61P25/00 , A61P25/16 , C12N5/071
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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14.发明授权Benzisoxazoles and azabenzisoxazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权作为MGLUR4变构增强剂的苯并异恶唑和氮杂苯并恶唑，组合物和治疗神经功能障碍的方法公开(公告)号：US08916584B2
公开(公告)日：2014-12-23
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , C07D491/048 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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15.发明申请Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权苯并恶唑和偶氮苯并恶唑作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130079366A1
公开(公告)日：2013-03-28
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , A61K31/437 , A61K31/423 , A61K45/06 , C07D261/20 , C07D491/048 , A61K31/4355
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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16.发明申请ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权ARYL和HETEROARYL SULFONES作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245185A1
公开(公告)日：2012-09-27
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , C07D417/04 , A61K31/427 , C07D213/81 , C12N5/02 , C07D307/68 , A61K31/341 , C07D239/28 , A61K31/505 , C07D401/04 , A61K31/4402
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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17.发明申请SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS 审中-公开作为MGLUR4电位的替代的杀伤甾烷酰胺和取代的吲哚磺酰胺公开(公告)号：US20120184556A1
公开(公告)日：2012-07-19
申请号：US13386651
申请日：2010-07-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/53 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/427 , A61K31/506 , A61K31/422 , A61K31/454 , C07D235/18 , C07D401/04 , C07D409/04 , C07D403/04 , C07D417/04 , C07D413/04 , C07D405/04 , A61K31/404 , A61K31/437 , A61K31/5025 , A61K31/4985 , A61K31/519 , C07D471/04 , C07D209/08 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/08 , A61P35/00 , A61P3/00 , A61P29/00 , A61P25/28 , C12N5/071 , C07D235/08 , C07D401/12 , C07D405/10 , A61K31/4545 , C07D401/14 , A61K31/4184
CPC分类号： A61K31/415 , A61K31/404 , A61K45/06 , C07D235/06 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
摘要翻译： 公开了取代的苯并咪唑磺酰胺和取代的吲唑磺酰胺作为mGluR4增效剂。
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18.发明授权Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的二氧代哌啶和二氧代吡咯烷作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08759377B2
公开(公告)日：2014-06-24
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/4439 , C07D401/12
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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19.发明授权Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权芳基和杂芳基砜作为mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08912336B2
公开(公告)日：2014-12-16
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： C07D401/04 , C07D417/04 , C07D213/81 , C07D239/28 , C07D307/56
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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![Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same](/abs-image/US/2014/04/15/US08697691B2/abs.jpg.150x150.jpg)
20.发明授权Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same 有权烷基3 - （（2-氨基乙基）氨基）-8-氮杂双环[3.2.1]辛烷-8-羧酸酯类似物作为选择性M1激动剂及其制备和使用方法公开(公告)号：US08697691B2
公开(公告)日：2014-04-15
申请号：US12975331
申请日：2010-12-21
申请人： P. Jeffrey Conn , Craig W. Lindsley , Michael R. Wood , Rocco D. Gogliotti , Colleen M. Niswender , Bruce J. Melancon , Evan P. Lebois
发明人： P. Jeffrey Conn , Craig W. Lindsley , Michael R. Wood , Rocco D. Gogliotti , Colleen M. Niswender , Bruce J. Melancon , Evan P. Lebois
IPC分类号： C07D471/08 , A61K31/439 , A61K31/4545 , A61K31/444 , A61K31/5377
CPC分类号： C07D451/04 , C07D451/10
摘要： In one aspect, the invention relates to compounds having a general structure: which are useful as selective allosteric or bitopic agonists of the M1 muscarinic receptor; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurodegenerative diseases, including Alzheimer's Disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其可用作M1毒蕈碱受体的选择性变构或苦味激动剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物例如治疗神经变性疾病（包括阿尔茨海默病）的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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