公开(公告)号：US20170197939A1

公开(公告)日：2017-07-13

申请号：US15300440

申请日：2015-04-01

Applicant: PFIZER INC.

Inventor： Sharanjeet Kaur Bagal ,  Jingrong Jean Cui ,  Samantha Elizabeth Greasley ,  Elizabeth Ann Lunney ,  Indrawan James McAlpine ,  Asako Nagata ,  Sacha Ninkovic ,  Kiyoyuki Omoto ,  Sarah Elizabeth Skerratt ,  Robert Ian Storer ,  Joseph Scott Warmus

IPC: C07D401/14 ,  A61K31/4439 ,  C07D401/12

CPC classification number: C07D401/14 ,  A61K31/4439 ,  C07D401/12

Abstract: The present invention relates to compounds of Formula I and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

公开(公告)号：US20160244475A1

公开(公告)日：2016-08-25

申请号：US15045679

申请日：2016-02-17

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue

IPC: C07H19/16 ,  C07H19/23 ,  C07H19/14

CPC classification number: C07H19/14 ,  A61K31/7064 ,  C07H19/16 ,  C07H19/23 ,  C07H19/24

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。

公开(公告)号：US09328096B2

公开(公告)日：2016-05-03

申请号：US14705272

申请日：2015-05-06

Applicant: PFIZER INC

Inventor： Sharanjeet Kaur Bagal ,  Jingrong Jean Cui ,  Samantha Elizabeth Greasley ,  Elizabeth Ann Lunney ,  Indrawan James McAlpine ,  Asako Nagata ,  Sacha Ninkovic ,  Kiyoyuki Omoto ,  Sarah Elizabeth Skerratt ,  Robert Ian Storer ,  Joseph Scott Warmus

IPC: A61P35/00 ,  C07D413/14 ,  A61P29/00 ,  C07D405/14 ,  A61K31/4439 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，其中取代基如本文所述，及其在药物中的用途，特别是作为TrkA拮抗剂。

公开(公告)号：US10709709B2

公开(公告)日：2020-07-14

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/04 ,  C07D239/42 ,  C07D239/84 ,  C07D251/18 ,  C07D487/04 ,  C07D491/048 ,  A61K31/137 ,  A61K31/53 ,  C07D237/22 ,  C07D251/16 ,  C07D471/06 ,  C07D519/00 ,  C07C255/34 ,  A61K31/02

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10428104B2

公开(公告)日：2019-10-01

申请号：US15045679

申请日：2016-02-17

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue

IPC: C07H19/14 ,  C07H19/23 ,  A61K31/7064 ,  C07H19/24 ,  C07H19/16

Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.

公开(公告)号：US20190284216A1

公开(公告)日：2019-09-19

申请号：US16297910

申请日：2019-03-11

Applicant: PFIZER INC.

Inventor： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC: C07F9/6574 ,  A61P35/00 ,  A61K47/68

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20190111060A1

公开(公告)日：2019-04-18

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  C07D491/048 ,  C07D487/04 ,  C07D251/18 ,  C07D239/84 ,  C07D239/42 ,  A61K31/137 ,  C07D471/06 ,  A61K31/53 ,  C07D519/00 ,  C07D237/22 ,  C07D251/16

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US09040515B2

公开(公告)日：2015-05-26

申请号：US14132567

申请日：2013-12-18

Applicant: Pfizer Inc.

Inventor： Martin Paul Edwards ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Indrawan James McAlpine ,  Sacha Ninkovic ,  Eugene Yuanjin Rui ,  Scott Channing Sutton ,  John Howard Tatlock ,  Martin James Wythes ,  Luke Raymond Zehnder

IPC: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。