公开(公告)号：US20090118610A1

公开(公告)日：2009-05-07

申请号：US12066862

申请日：2006-11-29

Applicant: Parag V. Karmarkar ,  Kimble Jenkins

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B5/055

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  A61N2001/086 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

Abstract translation: 用于促进介入治疗和/或装置体内放置的MRI兼容的定位和/或引导系统包括：（a）适于固定于患者的安装座; （b）具有被配置为附接到所述安装件以便能够可控地平移至少三个维度的内腔的靶向插管; 以及（c）细长探针，其被配置为在所述靶向插管腔中紧密地滑动地前进和后退，所述细长探针包括刺激或记录电极中的至少一个。 在操作中，瞄准套管可以与第一轨迹对准，并且被位置调节以便为具有针对细长探针的对应轨迹的目标位置提供期望的内部通路。 还描述了用于确定与轨迹相关联并用于确定安装调整的MR扫描平面的自动化系统。

公开(公告)号：US20080262584A1

公开(公告)日：2008-10-23

申请号：US12047832

申请日：2008-03-13

Applicant: Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore ,  J. Michael Shifflette

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore ,  J. Michael Shifflette

IPC: A61N1/05 ,  H01B7/06 ,  G01N3/20

CPC classification number: A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

Abstract translation: MRI / RF兼容引线包括至少一个导体，具有至少一个具有多层堆叠线圈配置的段的相应导体。 引线可以被配置为使得铅在局部组织中加热小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于至少峰值输入SAR的目标RF频率时不加热局部组织 约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关引线和方法。

公开(公告)号：US09492651B2

公开(公告)日：2016-11-15

申请号：US12047602

申请日：2008-03-13

Applicant: Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

Inventor： Paul A. Bottomley ,  Parag V. Karmarkar ,  Justin M. Allen ,  William A. Edelstein

IPC: A61N1/05 ,  A61N1/37 ,  A61N1/08

CPC classification number: A61N1/08 ,  A61N1/05 ,  A61N1/086 ,  A61N1/3718 ,  Y10T29/49117

Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2W/kg. Related devices and methods of fabricating leads are also described.

Abstract translation: RF / MRI兼容的引线包括至少一个导体，其沿​​长度方向至少翻转两次，并且可以在其长度的多个位置处至少翻转两次。 至少一个电引线可以被配置成使得引线将局部组织加热到小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于峰值输入处的目标RF频率时不加热局部组织 SAR至少约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关器件和方法。

公开(公告)号：US09248270B2

公开(公告)日：2016-02-02

申请号：US12047832

申请日：2008-03-13

Applicant: Parag V. Karmarkar ,  Paul A. Bottomley ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

Inventor： Parag V. Karmarkar ,  Paul A. Bottomley ,  Justin M. Allen ,  William A. Edelstein ,  Peter Piferi ,  Brian Gore

IPC: A61N1/05 ,  A61N1/04 ,  B29C33/12 ,  G01N3/32 ,  A61N1/08 ,  B29L31/00

CPC classification number: A61N1/08 ,  A61N1/0488 ,  A61N1/05 ,  A61N1/086 ,  B29C33/126 ,  B29L2031/753 ,  G01N3/32 ,  Y10T29/49071

Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.

Abstract translation: MRI / RF兼容引线包括至少一个导体，具有至少一个具有多层堆叠线圈配置的段的相应导体。 引线可以被配置为使得铅在局部组织中加热小于约10摄氏度（通常约5摄氏度或更低），或者当患者暴露于至少峰值输入SAR的目标RF频率时不加热局部组织 约4W / kg和/或全身平均SAR至少约2W / kg。 还描述了制造引线的相关引线和方法。

公开(公告)号：US09042958B2

公开(公告)日：2015-05-26

申请号：US12066862

申请日：2006-11-29

Applicant: Parag V. Karmarkar ,  Kimble Jenkins

Inventor： Parag V. Karmarkar ,  Kimble Jenkins

IPC: A61B5/05 ,  A61B5/055 ,  A61B5/0476 ,  A61B5/00 ,  A61B19/00 ,  A61N1/05 ,  G01R33/28 ,  G01R33/34 ,  A61B17/00 ,  A61N1/37 ,  A61N1/08 ,  G01R33/48 ,  A61N1/372

CPC classification number: A61B90/11 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/6847 ,  A61B5/6864 ,  A61B5/6865 ,  A61B5/7435 ,  A61B34/10 ,  A61B34/20 ,  A61B90/14 ,  A61B2017/00039 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M39/08 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/372 ,  A61N2001/086 ,  G01R33/285 ,  G01R33/286 ,  G01R33/287 ,  G01R33/288 ,  G01R33/34084 ,  G01R33/4808

Abstract: MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

Abstract translation: 用于促进介入治疗和/或装置体内放置的MRI兼容的定位和/或引导系统包括：（a）适于固定于患者的安装座; （b）具有被配置为附接到所述安装件以便能够可控地平移至少三个维度的内腔的靶向插管; 以及（c）细长探针，其被配置为在所述靶向插管腔中紧密地滑动地前进和后退，所述细长探针包括刺激或记录电极中的至少一个。 在操作中，瞄准套管可以与第一轨迹对准，并且被位置调节以便为具有针对细长探针的对应轨迹的目标位置提供期望的内部通路。 还描述了用于确定与轨迹相关联并用于确定安装调整的MR扫描平面的自动化系统。

公开(公告)号：US08509876B2

公开(公告)日：2013-08-13

申请号：US11573226

申请日：2005-08-09

Applicant: Parag V. Karmarkar

Inventor： Parag V. Karmarkar

IPC: A61B5/055

CPC classification number: A61N1/0534 ,  A61B5/055 ,  A61B34/20 ,  A61B90/11 ,  A61B90/37 ,  A61B2017/00039 ,  A61B2090/374 ,  A61B2090/3954 ,  A61N1/0529 ,  A61N1/086

Abstract: In vivo medical stimulation probes include an elongate lead having at least one stimulation electrode disposed on a distal portion thereof. The probes may include a plurality of axially spaced apart RF chokes disposed on and/or in an axially extending shielding layer of the lead in advance of the at least one electrode to inhibit induced RF current from forming and/or traveling along the shielding layer.

Abstract translation: 体内医疗刺激探针包括具有设置在其远端部分上的至少一个刺激电极的细长引线。 探针可以包括在至少一个电极之前设置在引线的轴向延伸的屏蔽层之上和/或轴向延伸的屏蔽层中的多个轴向间隔开的RF扼流圈，以抑制感应RF电流沿屏蔽层的形成和/或传播。

公开(公告)号：US08260399B2

公开(公告)日：2012-09-04

申请号：US12757961

申请日：2010-04-09

Applicant: Parag V. Karmarkar ,  Ergin Atalar

Inventor： Parag V. Karmarkar ,  Ergin Atalar

IPC: A61B5/055

CPC classification number: G01R33/287 ,  A61M25/0127 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0147 ,  G01R33/34084

Abstract: A deflectable tip catheter that is safe and effective for use in a magnetic resonance imaging environment. The deflectable tip catheter is configured such that it includes a built-in antenna, such as a loopless antenna or a loop antenna. The built-in antenna permits the deflectable tip catheter to be actively tracked and/or visualized. Depending upon the specific configuration of the deflectable tip catheter, the catheter may be tracked and/or visualized as a single unit, it may be tracked and/or visualized separate and independent of other components or instruments associated with the catheter, such as pull wires, injection needles, surgical instruments, and the like. The catheters described herein include injection type catheters and/or guidance type catheters.

Abstract translation: 一种可偏转的尖端导管，可安全有效地用于磁共振成像环境。 可偏转尖端导管被配置为使得其包括内置天线，例如无凹凸天线或环形天线。 内置天线允许可偏转的尖端导管被主动跟踪和/或可视化。 根据可偏转尖端导管的具体构造，导管可以作为单个单元进行跟踪和/或可视化，其可被跟踪和/或可视化分开并独立于与导管相关联的其它部件或器械，例如拉线 ，注射针，外科器械等。 本文所述的导管包括注射型导管和/或引导型导管。

公开(公告)号：US08433421B2

公开(公告)日：2013-04-30

申请号：US13290822

申请日：2011-11-07

Applicant: Ergin Atalar ,  Justin Allen ,  Paul Bottomley ,  William Eldelstein ,  Parag V. Karmarkar

Inventor： Ergin Atalar ,  Justin Allen ,  Paul Bottomley ,  William Eldelstein ,  Parag V. Karmarkar

IPC: A61N1/00

CPC classification number: A61N1/06 ,  A61N1/056 ,  A61N1/086

Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.

Abstract translation: 一些实施例涉及MRI / RF兼容医疗介入装置。 多个间隔开的高阻抗电路段被配置为在高频范围内具有高阻抗，并且在低频率范围内具有低阻抗。 高阻抗电路段可以包括共绕线圈电感器，并且可以在暴露于与高磁铁磁共振系统相关联的RF期间沿着引导系统（20）减少，阻止或抑制RJ-传输，同时置换低频生理 信号，治疗和/或刺激。 该装置可以包括至少一个电极。

公开(公告)号：US20120071953A1

公开(公告)日：2012-03-22

申请号：US13290822

申请日：2011-11-07

Applicant: Ergin Atalar ,  Justin Allen ,  Paul Bottomley ,  William Eldelstein ,  Parag V. Karmarkar

Inventor： Ergin Atalar ,  Justin Allen ,  Paul Bottomley ,  William Eldelstein ,  Parag V. Karmarkar

IPC: A61N1/04 ,  A61N1/36

CPC classification number: A61N1/06 ,  A61N1/056 ,  A61N1/086

Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.

Abstract translation: 一些实施例涉及MRI / RF兼容医疗介入装置。 多个间隔开的高阻抗电路段被配置为在高频范围内具有高阻抗，并且在低频率范围内具有低阻抗。 高阻抗电路段可以包括共绕线圈电感器，并且可以在暴露于与高磁铁磁共振系统相关联的RF期间沿着引导系统（20）减少，阻止或抑制RJ-传输，同时置换低频生理 信号，治疗和/或刺激。 该装置可以包括至少一个电极。

公开(公告)号：US07725161B2

公开(公告)日：2010-05-25

申请号：US10769994

申请日：2004-02-03

Applicant: Parag V. Karmarkar ,  Ergin Atalar

Inventor： Parag V. Karmarkar ,  Ergin Atalar

IPC: A61B5/055

CPC classification number: G01R33/287 ,  A61M25/0127 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0147 ,  G01R33/34084

Abstract: A deflectable tip catheter that is safe and effective for use in a magnetic resonance imaging environment. The deflectable tip catheter is configured such that it includes a built-in antenna, such as a loopless antenna or a loop antenna. The built-in antenna permits the deflectable tip catheter to be actively tracked and/or visualized. Depending upon the specific configuration of the deflectable tip catheter, the catheter may be tracked and/or visualized as a single unit, it may be tracked and/or visualized separate and independent of other components or instruments associated with the catheter, such as pull wires, injection needles, surgical instruments, and the like. The catheters described herein include injection type catheters and/or guidance type catheters.

Abstract translation: 一种可偏转的尖端导管，可安全有效地用于磁共振成像环境。 可偏转尖端导管被配置为使得其包括内置天线，例如无凹凸天线或环形天线。 内置天线允许可偏转的尖端导管被主动跟踪和/或可视化。 根据可偏转尖端导管的具体构造，导管可以作为单个单元进行跟踪和/或可视化，其可被跟踪和/或可视化分开并独立于与导管相关联的其它部件或器械，例如拉线 ，注射针，外科器械等。 本文所述的导管包括注射型导管和/或引导型导管。