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    Polynucleotides for mammalian secreted protein, Z1055G2P
    18.
    发明授权
    Polynucleotides for mammalian secreted protein, Z1055G2P 失效
    哺乳动物分泌蛋白多核苷酸，Z1055G2P

    公开(公告)号：US06822082B2

    公开(公告)日：2004-11-23

    申请号：US09893737

    申请日：2001-06-28

    申请人： Paul O. Sheppard ,  Scott R. Presnell

    发明人： Paul O. Sheppard ,  Scott R. Presnell

    IPC分类号： C07H2100

    CPC分类号： C07K14/52 ,  C07K14/47 ,  C07K2319/00

    摘要： The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 328, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.

    摘要翻译： 本发明提供了由多核苷酸编码的多核苷酸和分泌的蛋白质。 蛋白质包括多种融合蛋白，包括融合物，其包含选自SEQ ID NO：M所示的信号肽的信号肽，其中M为2至328的偶数整数，可操作地连接到第二多肽。 本发明还提供了利用多肽的多核苷酸，多肽和拮抗剂的治疗和诊断方法。

    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE
    19.
    发明申请
    ZCYTOR19 POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE 审中-公开
    ZCYTOR19多核苷酸，多肽，抗体和使用方法

    公开(公告)号：US20120064571A1

    公开(公告)日：2012-03-15

    申请号：US13267430

    申请日：2011-10-06

    申请人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    发明人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

    IPC分类号： C12P21/02 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00

    CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

    摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。