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公开(公告)号：US20210230196A1
公开(公告)日：2021-07-29
申请号：US17190924
申请日：2021-03-03
Applicant: PFIZER INC.
Inventor： Martin James Wythes , Indrawan James McAlpine , Ryan Patman , Eugene Yuanjin Rui , Andrew Fensome , Andreas Maderna , Mehran Jalaie , Ketan S. Gajiwala
IPC: C07F9/6574 , A61K47/68 , A61P35/00 , C07H19/213
Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US10538542B2
公开(公告)日：2020-01-21
申请号：US16297910
申请日：2019-03-11
Applicant: PFIZER INC.
Inventor： Martin James Wythes , Indrawan James McAlpine , Ryan Patman , Eugene Yuanjin Rui , Andrew Fensome , Andreas Maderna , Mehran Jalaie , Ketan S. Gajiwala
IPC: A61K31/7084 , C07H21/02 , C07H21/04 , C07F9/6574 , A61K47/68 , A61P35/00
Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20160244475A1
公开(公告)日：2016-08-25
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
CPC classification number: C07H19/14 , A61K31/7064 , C07H19/16 , C07H19/23 , C07H19/24
Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。
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公开(公告)号：US20200331909A1
公开(公告)日：2020-10-22
申请号：US16849329
申请日：2020-04-15
Applicant: Pfizer Inc.
Inventor： Samit Kumar Bhattacharya , Douglas Carl Behenna , Kimberly O. Cameron , Ping Chen , John M. Curto , Kevin Daniel Freeman-Cook , Mehran Jalaie , Robert Steven Kania , Yajing Lian , Sajiv Krishnan Nair , Cynthia Louise Palmer , Martin Youngjin Pettersson , Eugene Yuanjin Rui , Matthew Sammons , Qingyi Yang , Liying Zhang
IPC: C07D471/04 , A61P9/12
Abstract: This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.
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公开(公告)号：US10709709B2
公开(公告)日：2020-07-14
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , A61P35/02 , A61P35/04 , C07D239/42 , C07D239/84 , C07D251/18 , C07D487/04 , C07D491/048 , A61K31/137 , A61K31/53 , C07D237/22 , C07D251/16 , C07D471/06 , C07D519/00 , C07C255/34 , A61K31/02
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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Patent Agency Ranking
公开(公告)号：US10428104B2
公开(公告)日：2019-10-01
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
IPC: C07H19/14 , C07H19/23 , A61K31/7064 , C07H19/24 , C07H19/16
Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.
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公开(公告)号：US20190284216A1
公开(公告)日：2019-09-19
申请号：US16297910
申请日：2019-03-11
Applicant: PFIZER INC.
Inventor： Martin James Wythes , Indrawan James McAlpine , Ryan Patman , Eugene Yuanjin Rui , Andrew Fensome , Andreas Maderna , Mehran Jalaie , Ketan S. Gajiwala
IPC: C07F9/6574 , A61P35/00 , A61K47/68
Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20190111060A1
公开(公告)日：2019-04-18
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D491/048 , C07D487/04 , C07D251/18 , C07D239/84 , C07D239/42 , A61K31/137 , C07D471/06 , A61K31/53 , C07D519/00 , C07D237/22 , C07D251/16
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20180044344A1
公开(公告)日：2018-02-15
申请号：US15664265
申请日：2017-07-31
Applicant: Pfizer Inc.
Inventor： Douglas Carl Behenna , Ping Chen , Kevin Daniel Freeman-Cook , Robert Louis Hoffman , Mehran Jalaie , Asako Nagata , Sajiv Krishnan Nair , Sacha Ninkovic , Martha Alicia Ornelas , Cynthia Louise Palmer , Eugene Yuanjin Rui
IPC: C07D487/04 , C07D401/14
CPC classification number: C07D487/04 , C07D401/14 , C07D471/04
Abstract: This invention relates to compounds of general Formula (I) and pharmaceutically acceptable salts thereof, in which R1, R2, R2A, R2B, R3, R4, R5A, R5B, R6, R7, R8, R9, p, q and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US09040515B2
公开(公告)日：2015-05-26
申请号：US14132567
申请日：2013-12-18
Applicant: Pfizer Inc.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James McAlpine , Sacha Ninkovic , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes , Luke Raymond Zehnder
IPC: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。
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