公开(公告)号：US20210101998A1

公开(公告)日：2021-04-08

申请号：US17102883

申请日：2020-11-24

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K39/00 ,  A61K39/395 ,  A61K38/48

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

公开(公告)号：US10906955B2

公开(公告)日：2021-02-02

申请号：US15995286

申请日：2018-06-01

Applicant: Pfizer Inc. ,  Boston Medical Center Corporation

Inventor： Stephen Berasi ,  Janet Elizabeth Buhlmann ,  Nathan Higginson-Scott ,  Michael Shamashkin ,  Matthew Russo ,  Stefano V. Gulla ,  Zong Sean Juo ,  Sreekumar R. Kodangattil ,  Weining Lu ,  Xueping Fan ,  David J. Salant

IPC: C07K14/705 ,  C07K19/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/52 ,  C12N15/63 ,  C07H21/04 ,  A61P13/12 ,  A61K38/17 ,  A61K38/00

Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.

公开(公告)号：US20180346542A1

公开(公告)日：2018-12-06

申请号：US15995286

申请日：2018-06-01

Applicant: Pfizer Inc. ,  Boston Medical Center Corporation

Inventor： Stephen Berasi ,  Janet Elizabeth Buhlmann ,  Nathan Higginson-Scott ,  Michael Shamashkin ,  Matthew Russo ,  Stefano V. Gulla ,  Zong Sean Juo ,  Sreekumar R. Kodangattil ,  Weining Lu ,  Xueping Fan ,  David J. Salant

IPC: C07K14/705 ,  A61P13/12

CPC classification number: C07K14/70503 ,  A61K38/00 ,  C07K2319/30

Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.