公开(公告)号：US11072827B2

公开(公告)日：2021-07-27

申请号：US16239789

申请日：2019-01-04

Applicant: Quantum-Si Incorporated

Inventor： Guojun Chen ,  Jeremy Lackey ,  Alexander Goryaynov ,  Gerard Schmid ,  Ali Kabiri ,  Jonathan M. Rothberg ,  Todd Rearick ,  Jonathan C. Schultz ,  Farshid Ghasemi ,  Keith G. Fife

IPC: C12Q1/6869 ,  G01N21/64 ,  B01L3/00 ,  G01N30/86 ,  C08L1/02 ,  C12Q1/6806 ,  G01N27/447 ,  G01N30/88

Abstract: Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.

公开(公告)号：US20210129179A1

公开(公告)日：2021-05-06

申请号：US17067184

申请日：2020-10-09

Applicant: Quantum-Si Incorporated

Inventor： Guojun Chen ,  Jeremy Lackey

IPC: B05D1/00 ,  B05D3/10 ,  G01N33/543

Abstract: Aspects of the application provide methods of producing substrates having modified surfaces. In some aspects, methods of surface modification involve treating a surface of a substrate with an organic reagent in vapor phase to form an organic layer over the surface. In some aspects, methods of forming a stable surface coating on an oxidized surface are provided.

公开(公告)号：US12179204B2

公开(公告)日：2024-12-31

申请号：US16580877

申请日：2019-09-24

Applicant: Quantum-Si Incorporated

Inventor： Guojun Chen ,  James Beach ,  Kathren Fink Croce ,  Jeremy Lackey ,  Gerard Schmid

IPC: G02B6/136 ,  B01L3/00 ,  G02B6/132 ,  G02B6/12

Abstract: A method of forming an integrated device includes forming a sample well within a cladding layer of a substrate; forming a sacrificial spacer layer over the substrate and into the sample well; performing a directional etch of the sacrificial spacer layer so as to form a sacrificial sidewall spacer on sidewalls of the sample well; forming, over the substrate and into the sample well, a functional layer that provides a location for attachment of a biomolecule; and removing the sacrificial spacer material.

公开(公告)号：US20220186297A1

公开(公告)日：2022-06-16

申请号：US17552339

申请日：2021-12-15

Applicant: Quantum-Si Incorporated

Inventor： Brian Reed ,  An Li ,  Omer Ad ,  Haidong Huang ,  Guojun Chen

IPC: C12Q1/6823 ,  C12Q1/6837 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/58 ,  C12Q1/6804

Abstract: Methods and devices for ultrasensitive detection of target molecules (e.g., target nucleic acids or target proteins) from a biological sample are provided herein. In some embodiments, methods and devices enable ultrasensitive determination of the concentration of target molecules.

公开(公告)号：US11224878B2

公开(公告)日：2022-01-18

申请号：US15971493

申请日：2018-05-04

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Jeremy Lackey ,  Guojun Chen

IPC: B01L3/00 ,  C12Q1/6848 ,  C09D5/16 ,  C09D187/00 ,  C09D171/02

Abstract: Methods of preparing surfaces of sample wells are provided. In some aspects, methods of preparing a sample well surface involve contacting the sample well with a block copolymer to form an antifouling overlay over a metal oxide surface of the sample well. In some aspects, methods of passivating and/or selectively functionalizing a sample well surface are provided.