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公开(公告)号：US10155047B2
公开(公告)日：2018-12-18
申请号：US15447257
申请日：2017-03-02
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Ela Markovsky , Hemda Baabur-Cohen
IPC: A61K31/337 , A61K31/704 , A61K47/48 , A61K38/48
Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
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12.发明申请POLYMERS HAVING THERAPEUTICALLY ACTIVE AGENTS CONJUGATED THERETO, PROCESSES OF PREPARING SAME AND USES THEREOF 有权具有与其结合的治疗活性剂的聚合物，其制备方法及其用途公开(公告)号：US20150017115A1
公开(公告)日：2015-01-15
申请号：US14382776
申请日：2013-03-05
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Ela Markovsky , Hemda Baabur-Cohen
IPC: A61K47/48 , A61K31/337 , A61K31/704
CPC classification number: A61K47/48315 , A61K31/337 , A61K31/704 , A61K38/484 , A61K47/481 , A61K47/48176 , A61K47/482 , A61K47/48246 , A61K47/55 , A61K47/58 , A61K47/593 , A61K47/64 , A61K47/645 , A61K2300/00
Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
Abstract translation: 公开了由多个主链单元形成并且连接到主要部分的两个或多个治疗活性剂或一种或多种治疗活性剂和NCAM靶向部分的部分的聚合物骨架的聚合物缀合物。 还公开了这样的聚合物缀合物在治疗和/或监测与血管发生相关的癌症和/或医学病症中的用途。
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公开(公告)号：US20180169252A1
公开(公告)日：2018-06-21
申请号：US15737247
申请日：2016-06-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Samer Gnaim , Anna Scomparin
IPC: A61K47/54 , A61K31/4745 , A61K31/519 , A61K31/513 , A61K31/496 , A61K31/4184 , A61P35/00
Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.
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公开(公告)号：US20160145628A1
公开(公告)日：2016-05-26
申请号：US14899183
申请日：2014-06-18
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. , ROSETTA GENOMICS LTD.
Inventor： Noga Yerushalmi , Sharon Kredo-Russo , Gila Lithwick Yanai , Ronit Satchi-Fainaro , Paula Ofek
IPC: C12N15/113 , A61K31/713 , A61K47/48
CPC classification number: C12N15/1138 , A61K31/713 , A61K47/60 , C12N2310/141 , C12N2310/351
Abstract: Described herein are novel polyglycerol-amine polymeric nanocarriers in complex with microRNAs and their uses in the treatment of cancer, in particular glioblastoma. Delivery of the polymeric nanocarriers in complex with microRNAs in cell lines and in vivo inhibited cell proliferation, cell cycle progression, cell migration and tumor growth.
Abstract translation: 本文描述的是与微小RNA复合的新型聚甘油 - 胺聚合纳米载体及其在治疗癌症中的用途，特别是成胶质细胞瘤。 在细胞系和体内与微小RNA复合的聚合纳米载体的递送抑制细胞增殖，细胞周期进程，细胞迁移和肿瘤生长。
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Patent Agency Ranking
公开(公告)号：US09259482B2
公开(公告)日：2016-02-16
申请号：US14082224
申请日：2013-11-18
Applicant: Ramot at Tel-Aviv University Ltd. , Fundacion de la Comunidad Valenciana Centro de Investigacion Principe Felipe
Inventor： Ronit Satchi-Fainaro , Maria Jesus Vicent Docon
IPC: A61K31/74 , A61K47/48 , A61K31/336 , A61K31/337 , G01N33/68 , A61K49/00
CPC classification number: A61K47/48315 , A61K31/336 , A61K31/337 , A61K47/50 , A61K47/62 , A61K47/65 , G01N33/6893 , G01N2800/042 , G01N2800/102 , G01N2800/321 , G01N2800/323
Abstract: Conjugates of a polymer having attached thereto an angiogenesis targeting moiety and a therapeutically active agent such as an anti-cancer agent or anti-angiogenesis agent, and processes of preparing same are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of angiogenesis-related medical conditions such as cancer and cancer metastases are also disclosed.
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16.发明授权Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases 有权聚合物，双膦酸盐和抗血管生成剂的结合物及其在治疗和监测骨相关疾病中的用途公开(公告)号：US09095618B2
公开(公告)日：2015-08-04
申请号：US14158881
申请日：2014-01-20
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
IPC: A61K31/74 , A61K47/48 , C07F9/38 , C07F9/655 , C07F9/6558 , C07K5/065 , C07K5/103 , A61K31/337 , A61K49/00 , A61K9/16
CPC classification number: A61K47/48084 , A61K9/1676 , A61K31/337 , A61K47/548 , A61K47/58 , A61K47/65 , A61K49/0017 , A61K49/0054 , A61K2800/57 , C07F9/3873 , C07F9/65517 , C07F9/65586 , C07K5/06078 , C07K5/1008
Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Abstract translation: 公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。
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公开(公告)号：US10420845B2
公开(公告)日：2019-09-24
申请号：US15737247
申请日：2016-06-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Samer Gnaim , Anna Scomparin
IPC: C07D491/22 , A61K47/54 , A61K31/436 , A61K31/4188 , A61K31/497 , A61K31/519 , C07D487/04 , C07D215/44 , A61P35/00 , A61K31/4184 , A61K31/4745 , A61K31/496 , A61K31/513
Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.
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公开(公告)号：US10071983B2
公开(公告)日：2018-09-11
申请号：US15131129
申请日：2016-04-18
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro
IPC: A61K49/00 , C07D401/14 , C09B23/01 , C09B23/08 , C09B23/12 , G01N33/58 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , G01N33/52 , A61K47/54
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
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公开(公告)号：US09687562B2
公开(公告)日：2017-06-27
申请号：US14382776
申请日：2013-03-05
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Ela Markovsky , Hemda Baabur-Cohen
IPC: A61K47/48 , A61K38/48 , A61K31/337 , A61K31/704
CPC classification number: A61K47/48315 , A61K31/337 , A61K31/704 , A61K38/484 , A61K47/481 , A61K47/48176 , A61K47/482 , A61K47/48246 , A61K47/55 , A61K47/58 , A61K47/593 , A61K47/64 , A61K47/645 , A61K2300/00
Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
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