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    Optimized sensor geometry for an implantable glucose sensor
    15.
    发明授权
    Optimized sensor geometry for an implantable glucose sensor 有权
    优化的植入式葡萄糖传感器的传感器几何

    公开(公告)号：US07881763B2

    公开(公告)日：2011-02-01

    申请号：US11415631

    申请日：2006-05-02

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson ,  Mark A. Tapsak

    IPC分类号： A61B5/1473

    CPC分类号： A61B5/6882 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/415 ,  A61B5/418 ,  A61B2562/187

    摘要： An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

    摘要翻译： 一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上 使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。 身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。 几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。

    Porous membranes for use with implantable devices
    16.
    发明申请
    Porous membranes for use with implantable devices 有权
    用于可植入装置的多孔膜

    公开(公告)号：US20100256779A1

    公开(公告)日：2010-10-07

    申请号：US11654135

    申请日：2007-01-17

    申请人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    发明人： James H. Brauker ,  Victoria Carr-Brendel ,  Mark A. Tapsak

    IPC分类号： A61F2/02 ,  A61B5/05

    CPC分类号： A61L31/146 ,  A61L31/10 ,  A61L31/14

    摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

    摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。

    Oxygen enhancing membrane systems for implantable devices
    20.
    发明授权
    Oxygen enhancing membrane systems for implantable devices 有权
    用于可植入装置的氧增强膜系统

    公开(公告)号：US08909314B2

    公开(公告)日：2014-12-09

    申请号：US13187277

    申请日：2011-07-20

    申请人： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria E. Carr-Brendel ,  James H. Brauker

    发明人： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria E. Carr-Brendel ,  James H. Brauker

    IPC分类号： A61B5/145 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486

    CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

    摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

    摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。