摘要:
Solid dosage form for the controlled release of flavoxate hydrochloride is described. The dosage form includes a matrix allowing gradual release of the flavoxate hydrochloride contained within it, a suitable binder which limits the dimensions of the finished solid dosage form, and an acidifying agent which ensures stability of the flavoxate hydrochloride with time and improves its release profile by making it independent of pH.
摘要:
The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous or cutaneous systems as well as infective and tumoral diseases employing said compounds.
摘要:
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
摘要:
New compounds able to release COX-2 inhibitors and NO having formula (I): M-T-YA—NO2 (I) for the treatment and/or prophylaxis of inflammatory processes.
摘要:
Disclosed are controlled-release mucoadhesive pharmaceutical compositions for the oral administration of furosemide. This composition comprises a multiplicity of microgranules of lipophilic material which are coated with a mucoadhesive coating. This invention reduced or eliminates the diuresis peak and reduces inter-subject response variability which normally accompany conventional treatment with this drug.
摘要:
Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimensions which allow suspension of the coated microgranules in a liquid administration vehicle; and (c) a liquid administration vehicle for the coated microgranules, the vehicle including an effective amount of the pharmaceutical in a form immediately available upon ingestion. A process for the preparation of the controlled release therapeutic system is also described.
摘要:
New compounds able to release COX-2 inhibitors and NO having formula (I): M-T-YA—NO2 (I) for the treatment and/or prophylaxis of inflammatory processes.
摘要:
The present invention relates to new pharmaceutical compositions for the administration of liquid drugs in solid oral forms, said compositions comprising one or more active ingredients, one or more surface-active agents and optionally a co-surfactant and/or an absorption enhancer absorbed on a solid inert carrier.
摘要:
The present invention relates to the transdermal administration of alpha-adrenoceptor blocking compounds. The invention provides methods of administering these compounds to a patient in therapeutically effective amounts.