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20 条记录 (耗时 0.035 秒)

    Detection of vascular disease with labelled antibodies
    12.
    发明授权
    Detection of vascular disease with labelled antibodies 失效
    用标记抗体检测血管疾病

    公开(公告)号：US4877599A

    公开(公告)日：1989-10-31

    申请号：US220376

    申请日：1988-07-11

    申请人： Robert S. Lees

    发明人： Robert S. Lees

    IPC分类号： A61K49/16 ,  A61K51/10

    CPC分类号： A61K49/16 ,  A61K51/1018 ,  A61K2123/00 ,  Y10S514/824

    摘要： Vascular diseases including asymptomatic atherosclerosis can be diagnosed by administering a conjugate diagnostic reagent to a patient and then detecting the location and concentration of the conjugate reagent within the patient's vascular system. The conjugate reagents have a target-seeking, biologically active molecule as one component and a labeling means capable of extracorporeal detection as the other component. The biologically active molecules (BAMs) are chosen to have affinity for structural elements of the arterial wall which are either not present in the normal wall but are found in atherosclerotic or arteritic lesions, or which are not available to the blood-borne reagent within normal arterial walls, but are exposed to the reagent in atherosclerotic or arteriotic lesions.

    摘要翻译： 包括无症状动脉粥样硬化的血管疾病可以通过向患者施用缀合物诊断试剂，然后检测患者血管系统内缀合物的位置和浓度来诊断。 缀合物试剂具有作为一个成分的靶寻求的生物活性分子和能够作为其他组分进行体外检测的标记装置。 选择生物活性分子（BAM）对动脉壁的结构元件具有亲和性，所述结构元件不存在于正常壁中，但存在于动脉粥样硬化或动脉病变中，或者在正常情况下不能用于血液载体试剂 动脉壁，但暴露于动脉粥样硬化或动脉病变的试剂。

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    13.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US07244410B2

    公开(公告)日：2007-07-17

    申请号：US10616187

    申请日：2003-07-09

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： A61K51/10 ,  G01N33/53

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    18.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US07402395B2

    公开(公告)日：2008-07-22

    申请号：US10671242

    申请日：2003-09-24

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： G01N33/53 ,  C07K14/00

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

    Method and apparatus for estimating diameter of an artery using B-mode ultrasonic images
    19.
    发明授权
    Method and apparatus for estimating diameter of an artery using B-mode ultrasonic images 失效
    使用B模式超声图像估计动脉直径的方法和装置

    公开(公告)号：US5495852A

    公开(公告)日：1996-03-05

    申请号：US379852

    申请日：1995-01-27

    申请人： Robert W. Stadler ,  W. Clem Karl ,  Robert S. Lees

    发明人： Robert W. Stadler ,  W. Clem Karl ,  Robert S. Lees

    IPC分类号： A61B5/107 ,  A61B8/08 ,  A61B8/00

    CPC分类号： A61B8/0858 ,  A61B5/1076

    摘要： An improved apparatus and method for measuring the diameter of an artery utilizes an ultrasonic imaging plane that is rotated slightly from the centerline of an artery to produce a "skew" image of the artery. The invention detects edge points on the image of near and far walls of the artery. It fits curves to the near and far end edge points and measures distances between the curves. Alternatively, it fits one curve to all the edge points and measures a parameter (such as minor diameter of an ellipse) of the curve. Finally, it estimates arterial diameter from the measurement.

    摘要翻译： 用于测量动脉直径的改进的装置和方法利用从动脉中心线稍微旋转的超声成像平面，以产生动脉的“歪斜”图像。 本发明检测动脉近壁和远壁的图像上的边缘点。 它适合曲线到近端和远端边缘点，并测量曲线之间的距离。 或者，它适合于所有边缘点的一条曲线，并测量曲线的参数（如椭圆的小直径）。 最后，从测量中估计动脉直径。

    Method and means for detection of arterial lesions
    20.
    发明授权
    Method and means for detection of arterial lesions 失效
    检测动脉病变的方法和手段

    公开(公告)号：US4660563A

    公开(公告)日：1987-04-28

    申请号：US775093

    申请日：1985-09-11

    申请人： Robert S. Lees

    发明人： Robert S. Lees

    IPC分类号： A61B6/00 ,  A61K51/12

    CPC分类号： A61B6/4057 ,  A61B6/4258 ,  A61K51/1224 ,  A61K2123/00

    摘要： The atherosclerotic plaques which form arterial lesions have been found to take up lipoproteins from the blood flowing through the arteries. Accordingly, the early detection of arterial disease is accomplished by preparing an infusate composed of radiolabeled low-density lipoproteins and introducing the infusate into the patient's arterial system. A gamma radiation detector is then used to detect and quantify concentrations of the radiolabeled proteins thereby to indicate the locations and sizes of the lesions.

    摘要翻译： 已经发现形成动脉损伤的动脉粥样硬化斑块从流经动脉的血液中摄取脂蛋白。 因此，动脉疾病的早期检测是通过制备由放射性标记的低密度脂蛋白组成的灌注液并将输注物引入患者的动脉系统来完成的。 然后使用γ辐射检测器来检测和定量放射性标记的蛋白质的浓度，从而指示病变的位置和大小。