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公开(公告)号：US10250159B2
公开(公告)日：2019-04-02
申请号：US15767721
申请日：2016-11-07
申请人： Hongliang Wang , Yan-Fei Liu
发明人： Hongliang Wang , Yan-Fei Liu
IPC分类号： H02M7/483 , H02M1/32 , H02M7/5387 , H02M7/487
摘要： A five-voltage level inverter topology circuit and a three-phase five-voltage level inverter topology circuit, suitable for use with two series-connected direct current (DC) power sources, include a half-bridge inverter circuit having a first circuit module and a second circuit module. The half-bridge inverter circuit outputs five voltage levels including a 0V level. The five-voltage level inverter topology circuit has a five-voltage level half-bridge structure, and only requires an alternating current (AC) filtering inductor, thereby reducing system cost and size, removing leakage current, and providing high efficiency.
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公开(公告)号：US10116233B2
公开(公告)日：2018-10-30
申请号：US15885941
申请日：2018-02-01
申请人： Yang Chen , Hongliang Wang , Yan-Fei Liu , Zhanming Li , Yue Fu
发明人： Yang Chen , Hongliang Wang , Yan-Fei Liu , Zhanming Li , Yue Fu
摘要： A hybrid rectifier that works as either a hybrid full bridge or a voltage doubler. Under 220 V AC input condition, the hybrid rectifier operates in full bridge mode, while at 110 V AC input, it operates as voltage doubler rectifier. The hybrid rectifier may be used with a DC-DC converter, such as an LLC resonant converter, in a power supply. With this mode switching, the LLC converter resonant tank design only takes consideration of 220 V AC input case, such that the required operational input voltage range is reduced, and the efficiency of the LLC converter is optimized. Both the size and power loss are reduced by using a single stage structure instead of the conventional two-stage configuration.
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公开(公告)号：US20180241320A1
公开(公告)日：2018-08-23
申请号：US15751329
申请日：2016-08-15
申请人： Hongliang Wang , Yan-Fei Liu
发明人： Hongliang Wang , Yan-Fei Liu
IPC分类号： H02M7/483 , H02M7/5387 , H02S40/32
CPC分类号： H02M7/483 , H02M7/487 , H02M7/5387 , H02S40/32
摘要： Disclosed is single phase five-level inverter topology comprising a half-bridge inverter circuit with a floating capacitor which outputs five mutually different voltage levels including zero, wherein both the system cost and the size is reduced, the leakage current is eliminated substantially and high efficiency is achieved by using five-level half-bridge structure with only one AC filtering inductor. Provided also is three-phase five-level inverter topology wherein the voltage utilization is twice that of the present three-phase five-level half-bridge inverter under the same operating conditions; the AC filtering inductance is smaller than that of the three-level half-bridge inverter; the DC link mid-point voltage can be balanced without additional circuitry.
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公开(公告)号：US20180062537A1
公开(公告)日：2018-03-01
申请号：US15662044
申请日：2017-07-27
申请人： Hongliang Wang , Yan-Fei Liu
发明人： Hongliang Wang , Yan-Fei Liu
摘要： Hybrid modulation strategies are provided for single phase and three phase inverter topologies. According to hybrid modulation strategy embodiments, one line frequency period is divided into two operation modes based on the polarities of output voltage and output current. When polarities of the output voltage and output current are the same, a nominal voltage level modulation is used to generate the output voltage. When polarities of the output voltage and output current are opposite, a lower voltage level modulation is used to generate the output voltage. In one embodiment, a nominal voltage level modulation is five voltage level modulation, and a lower voltage level modulation is three or two voltage level modulation. Embodiments allow inverters to be constructed with fewer switches, and improve performance of multilevel inverters. The hybrid modulation strategies may be implemented in multilevel inverters such as active neutral point clamped (ANPC) and neutral point clamped (NPC) inverters.
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15.发明授权Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection 有权哒嗪衍生物及其用作治疗微小RNA病毒感染的药物公开(公告)号：US08846678B2
公开(公告)日：2014-09-30
申请号：US13813806
申请日：2011-08-02
申请人： Song Li , Hongliang Wang , Junhai Xiao , Xian Zhang , Lili Wang , Zhibing Zheng , Wu Zhong , Yunde Xie , Xingzhou Li , Xinbo Zhou , Guoming Zhao , Xiaokui Wang
发明人： Song Li , Hongliang Wang , Junhai Xiao , Xian Zhang , Lili Wang , Zhibing Zheng , Wu Zhong , Yunde Xie , Xingzhou Li , Xinbo Zhou , Guoming Zhao , Xiaokui Wang
IPC分类号： A61K31/501 , C07D237/20
CPC分类号： C07D237/20
摘要： Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
摘要翻译： 公开了由式I表示的哒嗪衍生物或其药学上可接受的盐或水合物，包含该化合物的药物组合物，使用该化合物治疗和/或预防与病毒感染相关的疾病或病症的方法，以及该化合物在制备中的用途 用于治疗和/或预防与病毒感染相关的疾病或病症的药物。 由式I表示的化合物具有抗病毒活性，特别是抗微小RNA病毒活性。 所示化合物中的符号在说明书中描述。
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公开(公告)号：US20180241318A1
公开(公告)日：2018-08-23
申请号：US15962102
申请日：2018-04-25
申请人： Yang Chen , Hongliang Wang , Yan-Fei Liu , Zhanming Li , Yue Fu
发明人： Yang Chen , Hongliang Wang , Yan-Fei Liu , Zhanming Li , Yue Fu
CPC分类号： H02M7/219 , H02M1/10 , H02M1/4208 , H02M1/4233 , H02M1/4241 , H02M3/3353 , H02M3/33592 , H02M3/337 , H02M7/217 , H02M2001/0058 , H02M2001/007
摘要： A hybrid rectifier that works as either a hybrid full bridge or a voltage doubler. Under 220 V AC input condition, the hybrid rectifier operates in full bridge mode, while at 110 V AC input, it operates as voltage doubler rectifier. The hybrid rectifier may be used with a DC-DC converter, such as an LLC resonant converter, in a power supply. With this mode switching, the LLC converter resonant tank design only takes consideration of 220 V AC input case, such that the required operational input voltage range is reduced, and the efficiency of the LLC converter is optimized. Both the size and power loss are reduced by using a single stage structure instead of the conventional two-stage configuration.
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公开(公告)号：US09973108B2
公开(公告)日：2018-05-15
申请号：US15662044
申请日：2017-07-27
申请人： Hongliang Wang , Yan-Fei Liu
发明人： Hongliang Wang , Yan-Fei Liu
摘要： Hybrid modulation strategies are provided for single phase and three phase inverter topologies. According to hybrid modulation strategy embodiments, one line frequency period is divided into two operation modes based on the polarities of output voltage and output current. When polarities of the output voltage and output current are the same, a nominal voltage level modulation is used to generate the output voltage. When polarities of the output voltage and output current are opposite, a lower voltage level modulation is used to generate the output voltage. In one embodiment, a nominal voltage level modulation is five voltage level modulation, and a lower voltage level modulation is three or two voltage level modulation. Embodiments allow inverters to be constructed with fewer switches, and improve performance of multilevel inverters. The hybrid modulation strategies may be implemented in multilevel inverters such as active neutral point clamped (ANPC) and neutral point clamped (NPC) inverters.
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18.发明申请公开(公告)号：US20130338064A1
公开(公告)日：2013-12-19
申请号：US13810098
申请日：2011-07-14
申请人： Yuling Liu , Cuiping Zhou , Zhihui Song , Lin Li , Hongliang Wang , Xuejun Xia , Renyun Wang , Wujun Dong , Dujia Jin
发明人： Yuling Liu , Cuiping Zhou , Zhihui Song , Lin Li , Hongliang Wang , Xuejun Xia , Renyun Wang , Wujun Dong , Dujia Jin
IPC分类号： C07K17/02
摘要： Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3˜1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
摘要翻译： 提供胰岛素 - 脂质复合物，其制备方法及其制剂。 胰岛素 - 脂质复合物通过将胰岛素和脂质材料混合在含有低沸点酸的有机溶剂体系中并干燥来制备。 胰岛素与脂质物质的质量比为1:3〜1:20。 进一步提供胰岛素 - 脂质复合物和含有胰岛素的囊泡的油溶液。
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公开(公告)号：US20120238566A1
公开(公告)日：2012-09-20
申请号：US13265692
申请日：2010-04-27
申请人： Chengyu Jiang , Shuan Rao , Haolin Liu , Feng Guo , Hongliang Wang , Yang Sun , Chenggang Li
发明人： Chengyu Jiang , Shuan Rao , Haolin Liu , Feng Guo , Hongliang Wang , Yang Sun , Chenggang Li
IPC分类号： A61K31/52 , C07D413/04 , A61K31/5377 , A61P11/00 , A61K31/4439 , C07D493/06 , A61K31/366 , A61P31/16 , C07D473/34 , C07D401/04
CPC分类号： A61K31/366 , A61K31/4439 , A61K31/52 , A61K31/5377
摘要： Use of cell autophagy (type II cell apoptosis) inhibitors for preventing and/or treating avian influenza, injury of lungs caused by avian influenza virus or nanometer materials. The cell autophagy (type II cell apoptosis) inhibitors are selected from 3-methyladenine, SB203580, LY294002, and or wortmannin. The injury of lungs includes acute respiratory distress syndrome. The avian influenza virus is H5N1, H5N2 or H9N2 avian influenza virus. The nanometer materials include PAMAM G3, G4, G5, G5.5, G6, G7, or G8.
摘要翻译： 使用细胞自噬（II型细胞凋亡）抑制剂预防和/或治疗禽流感，禽流感病毒或纳米材料造成的肺损伤。 细胞自噬（II型细胞凋亡）抑制剂选自3-甲基腺嘌呤，SB203580，LY294002和或渥曼青霉素。 肺损伤包括急性呼吸窘迫综合征。 禽流感病毒是H5N1，H5N2或H9N2禽流感病毒。 纳米材料包括PAMAM G3，G4，G5，G5.5，G6，G7或G8。
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公开(公告)号：US10447173B2
公开(公告)日：2019-10-15
申请号：US15770493
申请日：2017-03-17
申请人： Hongliang Wang , Yan-Fei Liu
发明人： Hongliang Wang , Yan-Fei Liu
摘要： A single-phase five-level active clamping converter unit and a converter. The single-phase five-level active clamping converter unit has three input ends and one output end, and also comprises: a suspension capacitor and a topological control portion. The topological control portion is connected to the suspension capacitor and the three input ends and one output end of the single-phase five-level active clamping converter unit, is connected to a plurality of control ends, and is suitable for the supply of at least eight operating modes under the control of a control signal accessing the control ends. In the single-phase five-level active clamping converter unit, a topological structure is easy to design, and is simple and convenient to control.
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