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公开(公告)号：US11759976B2
公开(公告)日：2023-09-19
申请号：US18016246
申请日：2021-07-14
发明人： Babu Padmanabhan , Indu Bhushan , Vinay Rao
CPC分类号： B29B9/02 , B01J2/16 , B01J2/20 , B29B9/08 , B29B9/16 , B29B2009/165 , B29B2009/168
摘要： A continuous granulation system for obtaining conditioned granules is disclosed. The system comprises a processor configured to produce a continuous flow of granules at an outlet of the processor. The system also comprises a collection chamber positioned downstream from the processor and configured to collect the granules from the outlet. Further, the system comprises an air displacement device coupled to the collection chamber and configured to create a unidirectional flow of air at the outlet in a direction of the granules exiting the processor and away from the outlet. The unidirectional flow of air conditions the granules obtained in the collection chamber. A continuous granulation method and a continuous granule collection system for obtaining the conditioned granules is also disclosed.
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公开(公告)号：US11247380B2
公开(公告)日：2022-02-15
申请号：US16373187
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号：US11247379B2
公开(公告)日：2022-02-15
申请号：US16373178
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号： B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要： Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号：US20210046439A1
公开(公告)日：2021-02-18
申请号：US17007641
申请日：2020-08-31
发明人： Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要： The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.
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公开(公告)号：US20190263043A1
公开(公告)日：2019-08-29
申请号：US16373187
申请日：2019-04-02
发明人： Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
摘要： Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号：US09956709B2
公开(公告)日：2018-05-01
申请号：US14888916
申请日：2014-05-27
IPC分类号： B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , A61K9/16 , A61K9/20 , B29K91/00 , B29K105/00
CPC分类号： B29C47/0011 , A61K9/1617 , A61K9/1694 , A61K9/2095 , B29C47/00 , B29C47/402 , B29C47/6075 , B29C47/805 , B29C47/807 , B29K2091/00 , B29K2105/0035
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号：US11180296B2
公开(公告)日：2021-11-23
申请号：US16494167
申请日：2018-03-14
摘要： A doser cap for liquid containers can include a cap having a storage chamber enclosing powder material or active substance that can be dispensed into the liquid container by rupturing an associated seal. The doser cap can include a bottom cap, top cap, cutting unit, spiral cam slot, pushing rib, and entry groove on top cap.
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公开(公告)号：US20180200938A1
公开(公告)日：2018-07-19
申请号：US15920133
申请日：2018-03-13
IPC分类号： B29C47/00 , B29C47/60 , A61K9/16 , A61K9/20 , B29C47/80 , B29C47/40 , B29K91/00 , B29K105/00
CPC分类号： B29C47/0011 , A61K9/1617 , A61K9/1694 , A61K9/2095 , B29C47/00 , B29C47/402 , B29C47/6075 , B29C47/805 , B29C47/807 , B29K2091/00 , B29K2105/0035
摘要： A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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