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公开(公告)号：US10336732B2
公开(公告)日：2019-07-02
申请号：US15819372
申请日：2017-11-21
发明人： Linghong Xie , Philip Glyn Jones , Kerry L. Spear , Noel Aaron Powell , Taleen G. Hanania , Vadim Alexandrov
IPC分类号： C07D405/04 , C07D413/04 , C07D493/04 , C07D405/14 , C07D413/14
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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公开(公告)号：US20190038594A1
公开(公告)日：2019-02-07
申请号：US16051863
申请日：2018-08-01
IPC分类号： A61K31/352 , A61K31/443 , A61K31/4433 , A61K31/506 , A61K31/4155 , A61K31/4178 , A61K31/497 , A61K31/427 , A61K31/42 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28
摘要： Compounds of Formula I are described as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need are also disclosed.
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公开(公告)号：US20190031685A1
公开(公告)日：2019-01-31
申请号：US15947343
申请日：2018-04-06
发明人： Philip G. Jones , Robert Lew , Kerry L. Spear , Linghong Xie
IPC分类号： C07D513/04 , A61K31/4985 , C07D401/04 , A61K31/437 , C07D401/12 , A61K31/444 , A61K31/4375 , C07D495/04 , A61K31/519 , A61K31/4709 , C07D231/56 , A61K31/496 , C07D215/26 , C07D471/04 , A61K45/06 , A61K31/551 , C07D401/14 , C07D519/00
摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.
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14.发明授权公开(公告)号：US09951088B2
公开(公告)日：2018-04-24
申请号：US14399334
申请日：2013-05-09
发明人： Philip G. Jones , Robert Lew , Kerry L. Spear , Linghong Xie
IPC分类号： A61K31/506 , C07D513/04 , C07D471/04 , C07D401/14 , C07D215/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D495/04 , C07D519/00 , A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K45/06 , A61K31/444
CPC分类号： C07D513/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K45/06 , C07D215/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/04 , C07D495/04 , C07D519/00
摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.
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15.发明申请1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS 有权1-异喹啉类化合物和用于治疗CNS病症的模拟物公开(公告)号：US20170001987A1
公开(公告)日：2017-01-05
申请号：US15041852
申请日：2016-02-11
发明人： Linghong Xie , Philip Glyn Jones , Kerry L. Spear , Noel Aaron Powell , Taleen G. Hanania , Vadim Alexandrov
IPC分类号： C07D405/04 , C07D413/14 , C07D405/14 , C07D493/04 , C07D413/04
CPC分类号： C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D493/04
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
摘要翻译： 其中A，R a，R 1，R 2，R 3，R 4，R 6，w和n 1在本文中定义和描述; 组合物; 及其使用方法。 这些化合物可用于治疗各种神经和精神疾病，例如本文所述的那些。
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公开(公告)号：US20150166571A1
公开(公告)日：2015-06-18
申请号：US14627355
申请日：2015-02-20
IPC分类号： C07D498/06 , A61K31/5383 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/4709 , A61K31/4164 , A61K31/4178 , C07D471/04 , C07D471/06 , C07D403/06 , C07D401/06 , C07D409/06 , C07D233/58 , C07D405/14 , C07D409/14 , A61K31/506
CPC分类号： C07D498/06 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/06 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
摘要翻译： 本文提供了杂芳基化合物，其合成方法，包含该化合物的药物组合物及其用途。 在一个实施方案中，本文提供的化合物可用于治疗，预防和/或治疗各种疾病，例如CNS障碍和代谢紊乱，包括但不限于例如神经障碍，精神病，精神分裂症，肥胖症， 和糖尿病。
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公开(公告)号：US11192885B2
公开(公告)日：2021-12-07
申请号：US16403698
申请日：2019-05-06
发明人： Linghong Xie , Philip Glyn Jones , Kerry L. Spear , Noel Aaron Powell , Taleen G. Hanania , Vadim Alexandrov
IPC分类号： C07D405/04 , C07D405/14 , C07D413/14 , C07D493/04 , C07D413/04
摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.
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公开(公告)号：US10780074B2
公开(公告)日：2020-09-22
申请号：US16051863
申请日：2018-08-01
IPC分类号： C07D413/04 , C07D417/04 , C07D405/04 , A61K31/352 , A61P25/28 , A61P25/24 , A61P25/08 , A61P25/16 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/497 , A61K31/506
摘要： Compounds of Formula I are described as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need are also disclosed.
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公开(公告)号：US20190308990A1
公开(公告)日：2019-10-10
申请号：US16214985
申请日：2018-12-10
IPC分类号： C07D493/04 , C07D307/87 , C07D311/76 , C07D313/08
摘要： Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.
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公开(公告)号：US10196403B2
公开(公告)日：2019-02-05
申请号：US15663688
申请日：2017-07-28
IPC分类号： C07D493/04 , C07D313/08 , C07D307/87 , C07D311/76
摘要： Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.
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