专利检索 ap:("Sunovion Pharmaceuticals Inc.") AND inv:"Linghong Xie" 第 1 页

1.

发明授权
1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders 有权

公开(公告)号：US09856238B2

公开(公告)日：2018-01-02

申请号：US15041852

申请日：2016-02-11

申请人： Sunovion Pharmaceuticals Inc. , PGI Drug Discovery LLC

发明人： Linghong Xie , Philip Glyn Jones , Kerry L. Spear , Noel Aaron Powell , Taleen G. Hanania , Vadim Alexandrov

IPC分类号： C07D405/04 , C07D413/14 , C07D405/14 , C07D493/04 , C07D413/04

CPC分类号： C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D493/04

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

2.

发明授权
Substituted quinoxalines as PDE-10 inhibitors 有权

公开(公告)号：US10562916B2

公开(公告)日：2020-02-18

申请号：US15787880

申请日：2017-10-19

申请人： SUNOVION PHARMACEUTICALS INC.

发明人： John Emmerson Campbell , Michael Charles Hewitt , Philip Xinhe Jones , Linghong Xie

IPC分类号： A61K31/498 , C07D241/40 , C07D498/06 , C07D401/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/14 , C07D519/00 , C07D403/06 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D498/04 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D471/06

摘要： Provided herein are cyclic nucleotide phosphodiesterase inhibitors, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous system and metabolic diseases and disorder.

3.

发明授权
Modulators of opioid receptors and methods of use thereof 有权
标题翻译：阿片类受体的调节剂及其使用方法

公开(公告)号：US09580409B2

公开(公告)日：2017-02-28

申请号：US14352294

申请日：2012-11-07

申请人： Sunovion Pharmaceuticals Inc.

发明人： Scott Malcolm , Carrie Bowen , Laurence Melnick , Linghong Xie

IPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D471/04 , C07D405/14 , C07D487/10 , C07D491/10 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/501 , A61K31/551 , A61K31/553

CPC分类号： C07D403/04 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/501 , A61K31/551 , A61K31/553 , C07D401/14 , C07D403/14 , C07D405/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/10 , C07D498/04

摘要： Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

摘要翻译： 本文提供的化合物及其合成方法。本文提供的化合物可用于治疗，预防和/或治疗各种疾病，例如疼痛，神经障碍，精神疾病和神经肌肉疾病。本文提供的化合物调节中枢神经系统或周围的阿片受体（例如，μ-阿片受体）的活性。本文还提供了含有化合物及其使用方法的药物制剂。

4.

发明申请
HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：异构体化合物及其使用方法

公开(公告)号：US20150072974A1

公开(公告)日：2015-03-12

申请号：US14399334

申请日：2013-05-09

申请人： SUNOVION PHARMACEUTICALS INC.

发明人： Phillip G. Jones , Robert Lew , Kerry L. Spear , Linghong Xie

IPC分类号： C07D513/04 , A61K31/4985 , A61K31/496 , A61K31/519 , C07D401/14 , A61K31/437 , C07D471/04 , C07D401/12 , A61K31/4709 , A61K45/06 , A61K31/551 , A61K31/4375

CPC分类号： C07D513/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/551 , A61K45/06 , C07D215/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/04 , C07D495/04 , C07D519/00

摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.

摘要翻译： 本文提供了杂芳基化合物，其合成方法，包含该化合物的药物组合物及其用途。在一个实施方案中，本文提供的化合物可用于治疗，预防和/或治疗各种疾病，例如CNS障碍和神经障碍，包括但不限于例如精神病，精神分裂症，抑郁症，运动障碍，和帕金森病。

5.

发明公开
TAAR1 AND SEROTONIN MODULATORS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开

公开(公告)号：US20240245658A1

公开(公告)日：2024-07-25

申请号：US18285975

申请日：2022-04-08

申请人： Sunovion Pharmaceuticals Inc.

发明人： Kevin Julian Hodgetts , Linghong Xie

IPC分类号： A61K31/4353 , A61K31/335 , A61K45/06 , C07D313/12 , C07D491/044

CPC分类号： A61K31/4353 , A61K31/335 , A61K45/06 , C07D313/12 , C07D491/044

摘要： Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., R1, R2, X1, X2, Y1, Y2, Y3, Y4, Y5, Y6, Y7, and Y8) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing, e.g., to treat a neurological or psychiatric disease or disorder.

6.

发明申请
COMPOUNDS AND USES THEREOF 有权

公开(公告)号：US20210093606A1

公开(公告)日：2021-04-01

申请号：US16991771

申请日：2020-08-12

申请人： Sunovion Pharmaceuticals Inc. , PGI Drug Discovery LLC

发明人： Carrie A. Bowen , Douglas F. Burdi , Michele L. R. Heffernan , Lee W. Herman , Linghong Xie

IPC分类号： A61K31/352 , C07D413/04 , C07D417/04 , C07D405/04 , A61P25/28 , A61P25/24 , A61P25/08 , A61P25/16 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/497 , A61K31/506

摘要： Compounds of Formula I are described as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need are also disclosed.

7.

发明申请
1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS 审中-公开

公开(公告)号：US20190389845A1

公开(公告)日：2019-12-26

申请号：US16403698

申请日：2019-05-06

申请人： Sunovion Pharmaceuticals Inc. , PGI Drug Discovery LLC

发明人： Linghong Xie , Philip Glyn JONES , Kerry L. SPEAR , Noel Aaron POWELL , Taleen G. HANANIA , Vadim ALEXANDROV

IPC分类号： C07D405/04 , C07D405/14 , C07D413/14 , C07D493/04 , C07D413/04

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.