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    Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides
    11.
    发明授权
    Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides 有权
    苯基取代的3-二氟甲基-1-甲基-1H-吡唑-4-甲酸N-甲氧基 - [1-甲基-2-苯基乙基]酰胺的制备方法

    公开(公告)号：US09051272B2

    公开(公告)日：2015-06-09

    申请号：US14374547

    申请日：2013-02-26

    Applicant: Syngenta Participations AG

    Inventor： Daniel Stierli ,  Harald Walter ,  Michael Rommel ,  Reinhard Georg Hanreich ,  Martin Zeller ,  Thomas Vettiger ,  Tomas Smejkal

    IPC: C07D231/12 ,  C07D231/14

    CPC classification number: C07D231/12 ,  C07D231/14

    Abstract: The invention relates to a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined in claim 1, which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R4—O—N═O (III)), wherein R4 is C1-C8alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H2N—O—CH3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C1-6 alkoxy, to the compound of formula (I).

    Abstract translation: 本发明涉及一种制备式（I）化合物的方法，其中R 1，R 2和R 3如权利要求1所定义，该方法包括：a）将式（II）化合物在 惰性有机溶剂与含有式（III）有机亚硝酸酯（R4-O-N = O（Ⅲ））的混合物，其中R4为C1-C8烷基，式（Ⅳ）化合物和惰性有机溶剂; b）将得到的式（Ⅴ）化合物与H 2 N-O-CH 3反应于式（Ⅶ）化合物，c）将式（Ⅶ）化合物还原为式（Ⅷ）化合物，d） 式Ⅸ化合物与式（Ⅸ）化合物反应，其中R *为卤素，羟基或C 1-6烷氧基。

    PROCESSES FOR THE PREPARATION OF PYRROLIDINE INTERMEDIATES
    13.
    发明申请
    PROCESSES FOR THE PREPARATION OF PYRROLIDINE INTERMEDIATES 有权
    制备吡咯烷酮中间体的方法

    公开(公告)号：US20140296527A1

    公开(公告)日：2014-10-02

    申请号：US14346773

    申请日：2012-09-28

    Applicant: SYNGENTA PARTICIPATIONS AG

    Inventor： Tomas Smejkal ,  Helmars Smits ,  Sebastian Volker Wendeborn ,  Guillaume Berthon ,  Jerome Yves Cassayre ,  Myriem El Qacemi

    IPC: C07D453/04 ,  C07C255/41 ,  C07D207/08 ,  C07D307/46 ,  C07D207/325 ,  C07D207/12

    CPC classification number: C07D453/04 ,  C07C253/10 ,  C07C253/30 ,  C07C255/40 ,  C07C255/41 ,  C07D207/08 ,  C07D207/12 ,  C07D207/267 ,  C07D207/325 ,  C07D207/333 ,  C07D207/40 ,  C07D307/46 ,  C07D409/12

    Abstract: The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermediates in the processes. The processes include those comprising(a-i) reacting a compound of formula Ia wherein P is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is aryl or heteroaryl, each optionally substituted; with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIa wherein P, R1 and R2 are as defined for the compound of formula Ia; and (a-ii) oxidising the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula VI wherein R1 and R2 are as defined for the compound of formula Ia.

    Abstract translation: 本发明涉及用于制备杀虫活性化合物的螺吡咯烷衍生物的对映选择性制备方法以及该方法中的中间体。 所述方法包括（a-i）使式Ia化合物（其中P为烷基，芳基或杂芳基）各自任意取代的化合物，其中杂芳基通过环碳原子在P连接; R1是氯二氟甲基或三氟甲基; R 2是芳基或杂芳基，各自任选被取代; 在存在手性催化剂的情况下产生氰化物源，得到式IIa化合物，其中P，R 1和R 2如对于式Ia化合物所定义; 和（a-ii）在酸存在下用过氧酸或过氧化物氧化式IIa化合物，得到式VI化合物，其中R 1和R 2如对于式Ia化合物所定义。

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