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    N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
    5.
    发明授权
    N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases 失效
    N-环己基苯甲酰胺和苯乙酰胺作为11-β-羟基类固醇脱氢酶的抑制剂

    公开(公告)号：US07932421B2

    公开(公告)日：2011-04-26

    申请号：US12000447

    申请日：2007-12-12

    申请人： Chester Chenguang Yuan ,  Nianhe Han ,  Qingyian Liu ,  Dustin McMinn ,  Jay Powers

    发明人： Chester Chenguang Yuan ,  Nianhe Han ,  Qingyian Liu ,  Dustin McMinn ,  Jay Powers

    IPC分类号： C07C233/00

    CPC分类号： C07C233/74 ,  C07C237/22 ,  C07C271/12 ,  C07C2601/02 ,  C07C2601/14 ,  C07D213/30 ,  C07D213/40

    摘要： The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, m, n, p, and q are as defined in the description; as well as pharmaceutical compositions comprising the same, methods of use of the compounds and compositions of the invention for the treatment of conditions associated with hydroxysteroid dehydrogenases (e.g., 11β-HSD1), and the use of the compounds of the invention in the preparation of medicaments for the treatment of hydroxysteroid dehydrogenase-associated conditions.

    摘要翻译： 本发明提供式（I）的N-环己基苯甲酰胺和苯乙酰胺化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，m，n，p ，和q如说明书中所定义; 以及包含其的药物组合物，使用本发明化合物和组合物的方法用于治疗与羟基类固醇脱氢酶（例如，11＆amp; -HSD1）相关的病症，以及本发明化合物在制剂中的用途 的用于治疗羟基类固醇脱氢酶相关病症的药物。