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公开(公告)号：US20060178435A1
公开(公告)日：2006-08-10
申请号：US11265576
申请日：2005-11-02
Applicant: Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
Inventor： Shaomeng Wang , Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang
IPC: C07C50/32 , A61K31/12 , A61K31/122 , A61K31/22
CPC classification number: C07C50/30 , A45C11/00 , A45C11/04 , A45C13/42 , C07C39/14 , C07C46/00 , C07C50/32 , C07C67/08 , C07C67/29 , C07C69/017 , C07C69/21
Abstract: The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及化合物果糖酚及其盐和前药。 聚鸟苷酸作为Bcl-2家族蛋白的抑制剂起作用。 本发明还涉及用于抑制过度增殖细胞生长，用于诱导细胞凋亡和促进细胞诱导凋亡细胞死亡的用途。
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12.发明授权Selective ligands for the dopamine 3 (D3) receptor and methods of using the same 有权多巴胺3（D3）受体的选择性配体及其使用方法公开(公告)号：US08283368B2
公开(公告)日：2012-10-09
申请号：US13060306
申请日：2009-08-27
Applicant: Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
Inventor： Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
IPC: A01N43/78 , A61K31/425
CPC classification number: C07D277/82 , C07D417/12
Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
Abstract translation: 公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式（I），其中X为C = O或SO 2，R 1为C 1-6烷基，R 2为芳基，杂芳基，芳基， - （CH 2）1-3芳基或 - （CH 2） 3杂芳基，n为0或1.D3受体配体在治疗其中D3受体的调节提供益处的疾病和病症方面也被公开。
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公开(公告)号：US20110319362A1
公开(公告)日：2011-12-29
申请号：US13128941
申请日：2009-12-07
Applicant: Shaomeng Wang , Jianyong Chen , Cindy Gomez , Longchuan Bai , Zaneta Nikolovska-Coleska , Yu-Jun Zhao
Inventor： Shaomeng Wang , Jianyong Chen , Cindy Gomez , Longchuan Bai , Zaneta Nikolovska-Coleska , Yu-Jun Zhao
IPC: A61K31/675 , C07D487/04 , A61P35/00 , A61K31/407 , A61K31/4178 , C07F9/6561 , C07D495/04
CPC classification number: C07D403/12 , A61K31/41 , C07D487/04
Abstract: Inhibitors of STAT3 are disclosed. Methods of using the STAT3 inhibitors in the treatment of diseases and conditions wherein inhibition of STAT3 provides a benefit, like cancers, also are disclosed.
Abstract translation: 公开了STAT3的抑制剂。 还公开了使用STAT3抑制剂治疗其中抑制STAT3提供益处的疾病和病症的方法，如癌症。
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公开(公告)号：US07910621B2
公开(公告)日：2011-03-22
申请号：US10594200
申请日：2005-03-22
Applicant: Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang , Shaomeng Wang , Haiying Sun , Liang Xu , Zengjian Hu
Inventor： Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang , Shaomeng Wang , Haiying Sun , Liang Xu , Zengjian Hu
IPC: A61K31/352 , C07D311/30
CPC classification number: C07C235/84 , C07C50/28 , C07C50/30 , C07D311/30
Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
Abstract translation: 本发明涉及XIAP家族蛋白质的天然存在和化学合成的小分子拮抗剂。 特别地，本发明提供了塞林和其他XIAP抑制剂以及使用这些化合物作为XIAP家族蛋白的抗凋亡作用的拮抗剂的方法。 本发明还提供了治疗疾病和病理（例如肿瘤性疾病）的方法。
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公开(公告)号：US20080021110A1
公开(公告)日：2008-01-24
申请号：US11729638
申请日：2007-03-29
Applicant: Shaomeng Wang , Jianyong Chen , John Keana , Ming Guo
Inventor： Shaomeng Wang , Jianyong Chen , John Keana , Ming Guo
CPC classification number: C07B57/00 , A61K31/192 , A61K31/78 , C07C45/516 , C07C45/79 , C07C45/85 , C07C47/57 , C07C51/487 , C07C53/08
Abstract: This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及生产棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体的方法。 本发明还涉及包含棉酚乙酸共晶和（ - ） - 棉酚乙酸共晶体的药物组合物，以及使用棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。
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Patent Agency Ranking
公开(公告)号：US20080021095A1
公开(公告)日：2008-01-24
申请号：US10594200
申请日：2005-03-22
Applicant: Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang , Shaomeng Wang , Haiying Sun , Liang Xu , Zengjian Hu
Inventor： Jianyong Chen , Zaneta Nikolovska-Coleska , Dajun Yang , Shaomeng Wang , Haiying Sun , Liang Xu , Zengjian Hu
IPC: A61K31/353 , A61K31/122 , A61P35/00 , C07C49/603 , C07D311/30 , C12N5/06
CPC classification number: C07C235/84 , C07C50/28 , C07C50/30 , C07D311/30
Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
Abstract translation: 本发明涉及XIAP家族蛋白质的天然存在和化学合成的小分子拮抗剂。 特别地，本发明提供了塞林和其他XIAP抑制剂以及使用这些化合物作为XIAP家族蛋白的抗凋亡作用的拮抗剂的方法。 本发明还提供了治疗疾病和病理（例如肿瘤性疾病）的方法。
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17.发明授权Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein 失效制备MDM2的小分子抑制剂的方法及其中使用的中间体公开(公告)号：US08742121B2
公开(公告)日：2014-06-03
申请号：US13614751
申请日：2012-09-13
Applicant: Shaomeng Wang , Ke Ding , Guoping Wang
Inventor： Shaomeng Wang , Ke Ding , Guoping Wang
IPC: C07D401/02 , C07D487/10 , C07D209/04
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US08664212B2
公开(公告)日：2014-03-04
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: A61K31/33 , C07D245/04 , C07D487/02
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120309961A1
公开(公告)日：2012-12-06
申请号：US13557804
申请日：2012-07-25
Applicant: Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
Inventor： Shaomeng Wang , Yuefeng Peng , Haiying Sun , Qian Cai , Zaneta Nikolovska-Coleska , Jianfeng Lu , Su Qiu
IPC: C07D487/04
CPC classification number: G01N33/5011 , C07D487/04
Abstract: The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Abstract translation: 本发明涉及作为细胞凋亡蛋白抑制剂抑制剂的Smac的重氮二环模拟物。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20120289494A1
公开(公告)日：2012-11-15
申请号：US13469928
申请日：2012-05-11
Applicant: Shaomeng Wang , Wei Sun , Angelo Aguilar , Carlos Garcia-Echeverria
Inventor： Shaomeng Wang , Wei Sun , Angelo Aguilar , Carlos Garcia-Echeverria
IPC: A61K31/407 , A61K31/5377 , A61P35/00 , A61K31/438 , A61K31/41 , C07D487/10 , C07D471/20
CPC classification number: C07D487/10
Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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