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公开(公告)号：US20110104658A1
公开(公告)日：2011-05-05
申请号：US12726140
申请日：2010-03-17
CPC分类号： G01N33/5082 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/56972
摘要： An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
摘要翻译： 用于测定用于药物和药物递送载体筛选的血脑屏障性质的装置和方法，包括具有分隔内腔和组织空间的间隙的微流体装置，从而能够形成类似于使用内皮细胞和脑细胞的体内条件的紧密连接。
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公开(公告)号：US20070231783A1
公开(公告)日：2007-10-04
申请号：US11393715
申请日：2006-03-31
CPC分类号： G01N33/54346
摘要： The present invention is a synthetic microfluidic microvasculature network and associated methods. The synthetic microfluidic microvasculature network mimics the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are also described. The invention has many uses including the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature such as inflammation, diabetes and hypertension.
摘要翻译： 本发明是合成微流控微血管网络及其相关方法。 合成微流体微血管网络模拟生理微血管网络的结构，流体流动特性和生理行为。 还描述了用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法。 本发明具有许多用途，包括优化药物递送和微血管治疗，并描述影响微血管的疾病机制，如炎症，糖尿病和高血压。
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公开(公告)号：US08589083B2
公开(公告)日：2013-11-19
申请号：US13332400
申请日：2011-12-21
IPC分类号： G01N33/48
CPC分类号： G01N33/54346
摘要： A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.
摘要翻译： 合成微流体微血管网络和相关方法模拟生理微血管网络的结构，流体流动特征和生理行为。 用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法被描述，其用于优化药物递送和微血管治疗以及描述影响微血管系统的疾病机制。
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公开(公告)号：US08435465B2
公开(公告)日：2013-05-07
申请号：US12263911
申请日：2008-11-03
IPC分类号： A61J1/06
CPC分类号： C12N15/1006 , C12M47/06 , Y10T436/11
摘要： A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.
摘要翻译： 用于分离具有含有维持在流化状态的官能化固体载体的捕获室的生物分子的微流体柱在微流体萃取期间提供降低的压降和气泡形成。 药筒可以包括电场溶解室和/或化学溶解室。 电场裂解室可以包括布置在两个相对的平面电极之间的电绝缘结构。
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15.发明授权公开(公告)号：US08380443B2
公开(公告)日：2013-02-19
申请号：US12612573
申请日：2009-11-04
IPC分类号： G01N33/48
CPC分类号： G01N33/5029 , G01N33/5032 , G01N33/5082 , G01N33/54366 , G01N33/56972
摘要： An apparatus and method for identifying and screening for agents affecting the leukocyte adhesion cascade (LAC) encompassing rolling, adhesion and migration comprises an optically clear, plastic microfluidic chip comprising flow channels with diameters in the range of 10-500 μm. The flow channels are coated with endothelial cells and at least a portion of the flow channels contains 1-30 μm sized openings, optionally filled with a native or synthetic extracellular matrix, that allow leukocyte migration into one or more tissue spaces.
摘要翻译： 用于鉴定和筛选影响包含滚动，粘附和迁移的白细胞粘附级联（LAC）的试剂的装置和方法包括光学透明的塑料微流体芯片，其包含直径在10-500μm范围内的流动通道。 流动通道涂覆有内皮细胞，并且流动通道的至少一部分包含1-30μm大小的开口，任选地填充有天然或合成的细胞外基质，其允许白细胞迁移到一个或多个组织空间中。
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公开(公告)号：US20100112667A1
公开(公告)日：2010-05-06
申请号：US12263911
申请日：2008-11-03
CPC分类号： C12N15/1006 , C12M47/06 , Y10T436/11
摘要： A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.
摘要翻译： 用于分离具有含有维持在流化状态的官能化固体载体的捕获室的生物分子的微流体柱在微流体萃取期间提供降低的压降和气泡形成。 药筒可以包括电场溶解室和/或化学溶解室。 电场裂解室可以包括布置在两个相对的平面电极之间的电绝缘结构。
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公开(公告)号：US20090292480A1
公开(公告)日：2009-11-26
申请号：US12428134
申请日：2009-04-22
CPC分类号： G01N33/54346
摘要： A synthetic microfluidic microvasculature network and associated methods mimic the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing particle adhesion and drug delivery are described with applications in the optimization of drug delivery and microvascular treatments and in describing disease mechanisms that affect the microvasculature.
摘要翻译： 合成微流体微血管网络和相关方法模拟生理微血管网络的结构，流体流动特征和生理行为。 用于模拟合成和生理微血管系统中的流动和颗粒粘附的计算方法以及用于确定影响颗粒粘附和药物递送的参数的方法被描述，其用于优化药物递送和微血管治疗以及描述影响微血管系统的疾病机制。
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公开(公告)号：US09731062B2
公开(公告)日：2017-08-15
申请号：US13598401
申请日：2012-08-29
CPC分类号： A61M1/3693 , A61M1/362 , B01D21/283 , B01D2221/10 , G01N33/491
摘要： Systems and methods for cleansing blood are disclosed herein. The methods include acoustically separating undesirable particles bound to capture particles from formed elements of whole blood. After introducing the capture particles to whole blood containing undesirable particles, the whole blood and capture particles are flowed through a microfluidic separation channel. At least one bulk acoustic transducer is attached to the microfluidic separation channel. A standing acoustic wave, imparted on the channel and its contents by the bulk acoustic transducer, drives the formed elements and undesirable particles bound to capture particles to specific aggregation axes. After aggregating the particles, the formed elements exit the separation channel through a first outlet and are returned to the patient. The undesirable particles, bound to the capture particles, exit through a second outlet and can be discarded to saved for later study.
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公开(公告)号：US07842006B2
公开(公告)日：2010-11-30
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译： 本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。 这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。 开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。 导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。
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公开(公告)号：US20130192462A1
公开(公告)日：2013-08-01
申请号：US13566297
申请日：2012-08-03
申请人： Kapil Pant , Shivshankar Sundaram , Yi Wang
发明人： Kapil Pant , Shivshankar Sundaram , Yi Wang
IPC分类号： B03C3/68
摘要： Disclosed is an electrostatic aerosol concentrator for the concentration of aerosol particles and their collection for subsequent analysis. The concentrator comprises an airflow chamber that includes alternately energized and grounded electrode elements that work in concert to impart radial inward motion to charged aerosol particles and focusing them toward an enriched aerosol outlet. If desired, filtered air inlets may be used to provide a sheath of aerosol-free air along the chamber periphery and prevent deposition of particles onto electrode surfaces. Aerosol particles entering the airflow chamber may carry a positive or negative charge naturally, or a charge may be induced on the particles using a charging section located upstream of the aerosol inlet. Natural or induced charges on the aerosol particles may be used to selectively concentrate subpopulations of aerosol particles from a mixture of particles. For example, bacterial spores or aerosolized viruses may be selectively enriched without concentrating other aerosol particles. The particles of interest are focused and collected at an aerosol rich outlet in a small air volume, while the majority of the airflow, stripped of particles of interest, is purged to the atmosphere through an aerosol lean outlet.
摘要翻译： 公开了一种用于浓缩气溶胶颗粒的静电气溶胶浓缩器及其收集用于随后的分析。 集中器包括气流室，其包括交替地供电和接地的电极元件，其一起工作以向带电的气溶胶颗粒进行径向向内运动并将它们聚焦到富集的气溶胶出口。 如果需要，可以使用过滤的空气入口来沿着室周边提供无气溶胶空气的护套，并防止颗粒沉积到电极表面上。 进入气流室的气溶胶颗粒可以自然携带正电荷或负电荷，或者可以使用位于气溶胶入口上游的充电部分在颗粒上诱导电荷。 气雾剂颗粒上的天然或诱导电荷可用于从颗粒混合物中选择性地浓缩气溶胶颗粒的亚群。 例如，细菌孢子或气雾化病毒可以选择性富集而不浓缩其它气溶胶颗粒。 将感兴趣的颗粒聚焦并收集在小气泡体积的气溶胶浓缩出口处，而大部分气流被汽提的感兴趣的颗粒通过气溶胶倾倒出口被吹扫到大气中。
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