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公开(公告)号：US07842006B2
公开(公告)日：2010-11-30
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译： 本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。 这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。 开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。 导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。
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公开(公告)号：US20080119780A1
公开(公告)日：2008-05-22
申请号：US11561303
申请日：2006-11-17
申请人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
发明人： Guiren Wang , Shivshankar Sundaram , Kapil Pant , Jianjun Feng , Peter Storm
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B2017/00778 , A61B2017/22001 , A61B2017/22021
摘要： The present invention is an ultrasonic thrombectomy catheter that produces physical forces (shear rates) strong enough to emulsify obstructions such as thrombi and emboli without causing damage to arterial walls. This is accomplished by properly arranging piezoelectric transducers within a catheter and a tubular catheter head separated by a gap to generate acoustic streaming that simultaneously emulsifies the obstruction and sweeps resulting debris into a catheter lumen for removal. The open gap may be formed by supporting struts that connect the catheter to the catheter head. The design of the catheter tip allows the fabrication of catheters capable of removing partial or complete blockages from arteries and other vessels having diameters as small as 2 mm.
摘要翻译： 本发明是一种超声波血栓切除术导管，其产生足够强的物理力（剪切速率）以乳化阻塞物如血栓和栓塞，而不会对动脉壁造成损伤。 这是通过将压电换能器适当地布置在导管内的管状导管头和由间隙分开的管状导管头来实现的，以产生声流，其同时乳化阻塞物并将所得碎片扫入导管腔以便移除。 开放间隙可以通过将导管连接到导管头上的支柱支撑而形成。 导管尖端的设计允许制造能够从直径小至2mm的动脉和其他容器中去除部分或完全阻塞的导管。
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公开(公告)号：US07998328B2
公开(公告)日：2011-08-16
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B03C5/02
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译： 提供微尺度，介电泳分离颗粒的方法和装置。 颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。 间隙距离和施加电位可用于控制所产生的介电电泳力。 使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。 方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。
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公开(公告)号：US20060290745A1
公开(公告)日：2006-12-28
申请号：US11167428
申请日：2005-06-27
申请人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
发明人： Jianjun Feng , Guiren Wang , Sivaramakrishnan Krishnamoorthy , Kapil Pant , Shivshankar Sundaram
IPC分类号： B41J2/05
摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.
摘要翻译： 提供微尺度，介电泳分离颗粒的方法和装置。 颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。 间隙距离和施加电位可用于控制所产生的介电电泳力。 使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。 方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。
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公开(公告)号：US07428848B2
公开(公告)日：2008-09-30
申请号：US11199754
申请日：2005-08-09
申请人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
发明人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
IPC分类号： G01N1/24
CPC分类号： G01N1/2202
摘要： The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.
摘要翻译： 本发明是用于低成本，高产量，高效率采样和浓缩生物气溶胶的静电收集器。 该装置足够小以便于携带并且可以被包含在典型的办公室或医院建筑物的墙壁内或放置在典型的办公室或医院建筑物的墙壁上。 收集器包括一个或多个收集器模块，每个收集器模块具有电离电极，圆锥形外部电极，湿式收集电极和液体收集系统。 通过收集器模块的气流可能被部分阻塞以增强较小颗粒的收集，并且收集电极可以包括多个可编程电极，以将颗粒沉积物聚焦到更小的区域上。 将颗粒收集到少量液体中，以便随后通过附着的分析仪或远程位置进行分析。
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公开(公告)号：US20070034025A1
公开(公告)日：2007-02-15
申请号：US11199754
申请日：2005-08-09
申请人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
发明人： Kapil Pant , Guiren Wang , Jianjun Feng , Shankar Sundaram
IPC分类号： G01N1/24
CPC分类号： G01N1/2202
摘要： The present invention is an electrostatic collector for low cost, high throughput, high efficiency sampling and concentration of bioaerosols. The device is small enough to be portable and can be contained within or placed on the wall of a typical office or hospital building. The collector comprises one or more collector modules, each having an ionizing electrode, a conical outer electrode, a wet collection electrode, and a liquid collection system. Airflow through a collector module may be partially blocked to enhance the collection of smaller particles and the collection electrode may comprise multiple, programmable electrodes to focus particle deposition onto a smaller area. Particles are collected into a small volume of liquid to facilitate subsequent analysis by an attached analyzer or at a remote site.
摘要翻译： 本发明是用于低成本，高产量，高效率采样和浓缩生物气溶胶的静电收集器。 该装置足够小以便于携带并且可以被包含在典型的办公室或医院建筑物的墙壁内或放置在典型的办公室或医院建筑物的墙壁上。 收集器包括一个或多个收集器模块，每个收集器模块具有电离电极，圆锥形外部电极，湿式收集电极和液体收集系统。 通过收集器模块的气流可能被部分阻塞以增强较小颗粒的收集，并且收集电极可以包括多个可编程电极，以将颗粒沉积物聚焦到更小的区域上。 将颗粒收集到少量液体中，以便随后通过附着的分析仪或远程位置进行分析。
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公开(公告)号：US09283597B2
公开(公告)日：2016-03-15
申请号：US11516269
申请日：2006-09-06
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译： 描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。 微型泵应用于微流体系统，如生物芯片。 自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。
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公开(公告)号：US20070110625A1
公开(公告)日：2007-05-17
申请号：US11516269
申请日：2006-09-06
IPC分类号： B01L3/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译： 描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。 微型泵应用于微流体系统，如生物芯片。 自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。
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9.发明申请公开(公告)号：US20070206179A1
公开(公告)日：2007-09-06
申请号：US11368063
申请日：2006-03-03
申请人： Guiren Wang , Hong Jiang
发明人： Guiren Wang , Hong Jiang
CPC分类号： G01F1/7086 , G01F1/712 , G01P5/001 , G01P5/26
摘要： Methods and apparatus for fluid flow velocity and flow rate measurement are provided. Fluid velocity is measured in optical method based on fluorescence photobleaching of a fluorescent dye. The invented method and apparatus requires a calibration relation between flow velocity and fluorescence signal and is easy to use. The invented method and apparatus can measure bulk flow velocity and flow rate inline, two and three components of flow velocity vector. It can also measure flow velocity in near wall region using evanescent wave. Since the invented method and apparatus uses molecular dye and calibration relation between flow velocity and fluorescence signal, it has ultra high spatial and temporal resolution. The invented method can be used not only to apparatuses and devices in conventional size, but also to that in MEMS and NEMS.
摘要翻译： 提供了流体流速和流速测量的方法和装置。 基于荧光染料的荧光光漂白的光学方法测量流体速度。 本发明的方法和装置需要流速和荧光信号之间的校准关系，并且易于使用。 本发明的方法和装置可以测量流速矢量的流速和流速，流速矢量的两个和三个分量。 它还可以使用ev逝波测量近壁区域的流速。 由于本发明的方法和装置使用分子染料和流速与荧光信号之间的校准关系，因此具有超高的空间和时间分辨率。 本发明的方法不仅可以用于常规尺寸的装置和装置，而且可以用于MEMS和NEMS中的装置和装置。
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10.发明授权公开(公告)号：US07283215B2
公开(公告)日：2007-10-16
申请号：US11368063
申请日：2006-03-03
申请人： Guiren Wang , Hong Jiang
发明人： Guiren Wang , Hong Jiang
IPC分类号： G01P3/36
CPC分类号： G01F1/7086 , G01F1/712 , G01P5/001 , G01P5/26
摘要： Methods and apparatus for fluid flow velocity and flow rate measurement are provided. Fluid velocity is measured in optical method based on fluorescence photobleaching of a fluorescent dye. The invented method and apparatus requires a calibration relation between flow velocity and fluorescence signal and is easy to use. The invented method and apparatus can measure bulk flow velocity and flow rate inline, two and three components of flow velocity vector. It can also measure flow velocity in near wall region using evanescent wave. Since the invented method and apparatus uses molecular dye and calibration relation between flow velocity and fluorescence signal, it has ultra high spatial and temporal resolution. The invented method can be used not only to apparatuses and devices in conventional size, but also to that in MEMS and NEMS.
摘要翻译： 提供了流体流速和流速测量的方法和装置。 基于荧光染料的荧光光漂白的光学方法测量流体速度。 本发明的方法和装置需要流速和荧光信号之间的校准关系，并且易于使用。 本发明的方法和装置可以测量流速矢量的流速和流速，流速矢量的两个和三个分量。 它还可以使用ev逝波测量近壁区域的流速。 由于本发明的方法和装置使用分子染料和流速与荧光信号之间的校正关系，因此具有超高的空间和时间分辨率。 本发明的方法不仅可以用于常规尺寸的装置和装置，而且可以用于MEMS和NEMS中的装置和装置。
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