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公开(公告)号：US07563870B2
公开(公告)日：2009-07-21
申请号：US10877373
申请日：2004-06-25
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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公开(公告)号：US06794131B1
公开(公告)日：2004-09-21
申请号：US09341829
申请日：1999-10-18
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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13.发明授权Isolated nucleic acid molecule coding for tumor rejection antigen precursors MAGE-C1 and MAGE-C2 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-C1和MAGE-C2的分离的核酸分子及其用途公开(公告)号：US06475783B1
公开(公告)日：2002-11-05
申请号：US09066281
申请日：1998-04-24
IPC分类号： C12M1585
CPC分类号： G01N33/56977 , C07K14/4748
摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.
摘要翻译： 本发明涉及分离的核酸分子，其编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原，导致表达它的肿瘤细胞的裂解。 本发明还涉及被设计用于编码由肿瘤细胞表达的抗原以及由核酸分子转染的细胞或包含核酸分子的载体的载体。 由于这些代码也是本发明的一部分的核酸分子和抗原的性质引起的各种治疗和诊断用途。
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公开(公告)号：US6130052A
公开(公告)日：2000-10-10
申请号：US206537
申请日：1998-12-07
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K48/00 , A61P35/02 , C07K14/435 , C07K14/47 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/574
CPC分类号： C07K14/4748 , C12Q1/6886 , A61K38/00 , C12Q2600/158
摘要： The invention describes leukemia associated genes, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a preproTRH, tryptase-L and/or Oct-T1 gene product.
摘要翻译： 本发明描述了白血病相关基因，包括其片段和生物功能变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以前trR，类胰蛋白酶-L和/或Oct-T1基因产物表达为特征的病症的方法和产品。
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15.发明授权
公开(公告)号：US5958711A
公开(公告)日：1999-09-28
申请号：US177909
申请日：1998-10-23
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
摘要翻译： 公开了新的肿瘤排斥抗原前体和编码它们的核酸分子。 这些肿瘤排斥抗原前体被称为NAG肿瘤排斥抗原前体，编码它们的核酸分子被称为NAG编码分子。 描述了编码序列和肿瘤排斥抗原前体分子的各种诊断和治疗用途。
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16.发明授权
公开(公告)号：US5821122A
公开(公告)日：1998-10-13
申请号：US487135
申请日：1995-06-07
IPC分类号： G01N33/50 , A61K35/26 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C07K14/74 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/15 , G01N33/53 , C07H21/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.
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17.发明授权公开(公告)号：US07851212B2
公开(公告)日：2010-12-14
申请号：US10275993
申请日：2001-05-07
申请人： Neil Berinstein , James Tartaglia , John A. Tine , Philippe Moingeon , Thierry Boon-Falleur , Pierre Vander Bruggen
发明人： Neil Berinstein , James Tartaglia , John A. Tine , Philippe Moingeon , Thierry Boon-Falleur , Pierre Vander Bruggen
IPC分类号： C12N15/63
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
摘要： The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
摘要翻译： 本发明公开了包含选自MAGE蛋白家族的不同（即不连续的）成员的几种MAGE特异性抗原表位的免疫原性多肽，其编码的核酸，包含所述核酸的重组病毒和/或细胞及其组合物。 还公开了使用上述免疫原性诱导或诱导MAGE特异性免疫应答的方法。
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公开(公告)号：US20060211091A1
公开(公告)日：2006-09-21
申请号：US11439334
申请日：2006-05-23
申请人： Yi Zhang , Pascal Chaux , Thierry Boon-Falleur , Pierre Bruggen
发明人： Yi Zhang , Pascal Chaux , Thierry Boon-Falleur , Pierre Bruggen
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
摘要翻译： 本发明描述了由MAGE-A3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-A3基因表达为特征的病症的方法和产品。
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公开(公告)号：US07001999B1
公开(公告)日：2006-02-21
申请号：US09183789
申请日：1998-10-30
CPC分类号： C07K14/4748 , A61K39/00 , A61K39/0011 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention describes SAGE (sdph3.10) and sdp3.5 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acid molecules, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdph3.10 and/or sdp3.5 gene product.
摘要翻译： 本发明描述了SAGE（sdph3.10）和sdp3.5肿瘤相关核酸，包括其片段和生物功能变体。 还包括由这种核酸分子编码的多肽和其片段，以及与其相关的抗体。 还提供了用于诊断和治疗以sdph3.10和/或sdp3.5基因产物表达为特征的病症的方法和产品。
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20.发明申请公开(公告)号：US20050249743A1
公开(公告)日：2005-11-10
申请号：US11032498
申请日：2005-01-10
CPC分类号： C07K14/4748 , A61K38/00
摘要： Peptides which consist of amino acid sequences found in MAGE-4 bind to HLA-A24 to form T cell epitopes. The therapeutic and diagnostic ramifications of this are the subject of this invention, as are various products obtained in the course of the development of the invention.
摘要翻译： 由MAGE-4中发现的氨基酸序列组成的肽与HLA-A24结合形成T细胞表位。 本发明的治疗和诊断结果是本发明的主题，以及在本发明的开发过程中获得的各种产品。
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