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公开(公告)号：US20060089047A1
公开(公告)日：2006-04-27
申请号：US11258478
申请日：2005-10-25
申请人： Stephane Olivier , Jerome Geyer , Gerard Muller
发明人： Stephane Olivier , Jerome Geyer , Gerard Muller
IPC分类号： H01R13/40
CPC分类号： B23P19/04 , A61B17/3417 , A61B17/3421 , A61M5/158 , A61M5/162 , A61M25/06 , A61M25/065 , A61M2005/1623 , Y10T29/49826 , Y10T29/49892 , Y10T29/49895 , Y10T29/49897 , Y10T29/49899 , Y10T29/49947
摘要： A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle further comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.
摘要翻译： 起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持 相对于彼此的中空喷枪和管道，使得插口从保持体突出，所述针还包括两个凸缘，该两个凸缘由于设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧并与其间隔开，所述 凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。
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公开(公告)号：US20050266577A1
公开(公告)日：2005-12-01
申请号：US11195517
申请日：2005-08-02
申请人： John Lynch , Michele Dumon , Alan Weiss , Kenneth Desilets , Stephane Olivier
发明人： John Lynch , Michele Dumon , Alan Weiss , Kenneth Desilets , Stephane Olivier
CPC分类号： G01N1/4005 , B01D61/18 , B01D63/081 , B01D2315/08 , B01L3/50255 , B01L2200/0631 , B01L2300/0829 , G01N2001/4016
摘要： The combination of a supported UF membrane having low non-specific binding (NSB) and high protein retention of the tested chemical entity (CE) in a device that is SBS complaint. The membrane is heat sealed to form one or more integral wells that are used to reduce NSB and improve protein retention and provides a simple, flexible way to reduce CE, such as drug and drug candidate (and other small molecule) NSB so that drug binding studies may more closely predict the behavior of these compounds in vivo.
摘要翻译： 在SBS投诉的装置中，具有低非特异性结合（NSB）的支持的UF膜和测试化学实体（CE）的高蛋白质保留的组合。 膜被热密封以形成一个或多个用于减少NSB并改善蛋白质保留的整合孔，并提供简单，灵活的方式来减少CE，例如药物和药物候选物（和其他小分子）NSB，使得药物结合 研究可能更密切地预测这些化合物在体内的行为。
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公开(公告)号：US06716350B2
公开(公告)日：2004-04-06
申请号：US10138597
申请日：2002-05-03
申请人： Stephane Olivier , Alan J. Weiss
发明人： Stephane Olivier , Alan J. Weiss
IPC分类号： B01D6300
CPC分类号： B01L3/50255 , B01L3/5085 , B01L9/523 , B01L2300/04 , B01L2300/0829 , C12M23/12 , C12M23/38
摘要： A laboratory device design particularly for a multiplate format that includes a tray having at least one well with a support associated with the well, and a removable undercover. The undercover protects the support or membrane from external contamination without causing excessive force on an individual well that can cause membrane flatness. The undercover is easily removable to provide access to the support or membrane. The undercover, when affixed to the underside of the multiwell plate or tray, allows the assembly to be transportable as a single unit while still being in compliance with SBS automation standards.
摘要翻译： 一种特别用于多重格式的实验室装置设计，其包括具有至少一个具有与所述井相关联的支撑的井的托盘和可移除的底盖。 底部保护支撑物或膜免受外部污染，而不会对单个孔造成过大的力，可能导致膜平坦度。 卧底易于拆卸，以提供对支架或膜的通路。 卧底，当固定在多孔板或托盘的底面时，允许组件作为单个单元运输，同时仍符合SBS自动化标准。
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公开(公告)号：US10549218B2
公开(公告)日：2020-02-04
申请号：US14119496
申请日：2012-06-08
申请人： Stephane Olivier , Didier Metz
发明人： Stephane Olivier , Didier Metz
摘要： The invention relates to the filtering of liquid samples, preferably in a laboratory environment, for example for collecting micro organisms from the liquid sample for subsequent testing. The invention provides a method for filtering a liquid sample which comprises providing a blank of a deformable sheet material and a filtration medium, deforming the blank to form a funnel extending above and about the filtration medium, introducing the liquid sample to be filtered into the so formed funnel, and filtering the liquid sample from the funnel through the filtration medium, for example to a downstream receptacle. The method is accordingly based on the concept that the funnel is not or at least not completely preformed but provided in a form of a blank of a deformable material sheet which is deformed so as to form the funnel at the point and time of use during filtration.
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公开(公告)号：US20100173335A1
公开(公告)日：2010-07-08
申请号：US12727273
申请日：2010-03-19
申请人： Raphael Grinon , Stephane Olivier
发明人： Raphael Grinon , Stephane Olivier
IPC分类号： C12Q1/66
CPC分类号： G01N21/763 , G01N35/10
摘要： The device includes means for holding a support (19) adapted to retain microorganisms in a predetermined position in which a first face (10) of said support (19) is in a first predetermined location and a second face (11) of said support (19) is in a second predetermined location, a station (2) for spraying onto said support (19) a reagent for revealing the presence of ATP by luminescence, said station (2) facing said first location, and a station (4) for measuring said luminescence opposite the spraying station and facing said second location.The method includes the step of procuring a device of the above kind, the step of disposing said support (19) at said predetermined location, the step of spraying said reagent onto said support (19) and, simultaneously with the spraying step, the step of measuring the quantity of light emitted in response to said reagent.
摘要翻译： 该装置包括用于保持适于将微生物保持在其中所述支撑件（19）的第一面（10）处于第一预定位置的预定位置和所述支撑件的第二面（11）的支撑件（19）的装置 19）位于第二预定位置，用于喷射到所述支撑件（19）上的用于通过发光显露ATP存在的试剂的所述站（2），所述站（2）面向所述第一位置，以及站（4），用于 测量与喷射站相对的所述发光并面对所述第二位置。 该方法包括获得上述装置的步骤，将所述支撑件（19）设置在所述预定位置的步骤，将所述试剂喷射到所述支撑件（19）上的步骤，并且在喷涂步骤的同时， 测量响应于所述试剂发射的光量。
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公开(公告)号：US20090104687A1
公开(公告)日：2009-04-23
申请号：US12287609
申请日：2008-10-10
申请人： Bertrand Engel , Pierre Guedon , Stephane Olivier
发明人： Bertrand Engel , Pierre Guedon , Stephane Olivier
IPC分类号： C12M1/34
CPC分类号： G01N1/28 , C12N13/00 , G01N1/4077 , G01N1/44 , H05B6/806
摘要： The microbiological analysis system comprises a support (6) adapted to retain microorganisms in the neighborhood of a planar surface (24), said support (6) belonging to a predetermined type with which is associated a specific arrangement criterion, and an analysis machine comprising a magnetron, a microwave cavity (100) linked to said magnetron provided to operate in resonant mode, a receptacle (30) for receiving said support (6), an obstacle (137) for tuning the resonant mode of the cavity (100) entering partially into said cavity (100), said obstacle (137) occupying a predetermined position depending on said predetermined type, means for recognizing said specific arrangement criterion, and a control unit connected to said magnetron and to said recognizing means and adapted to verify for said support (6) whether the specific arrangement criterion is met and to refuse to launch an analysis cycle otherwise.
摘要翻译： 微生物分析系统包括适于将微生物保持在平坦表面（24）附近的支撑件（6），所述支撑件（6）属于与特定布置标准相关联的预定类型，以及包括 磁控管，连接到所述磁控管的微波腔（100），其设置为以共振模式操作;容纳器（30），用于接收所述支撑件（6）;障碍物（137），用于调谐所述空腔（100）的谐振模式部分地进入 进入所述空腔（100），所述障碍物（137）根据所述预定类型占据预定位置，用于识别所述特定布置标准的装置，以及连接到所述磁控管和所述识别装置并适于验证所述支撑件的控制单元 （6）是否符合具体安排标准，否则拒绝启动分析循环。
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公开(公告)号：US07467932B2
公开(公告)日：2008-12-23
申请号：US11152517
申请日：2005-06-14
CPC分类号： F04B43/1284
摘要： The peristaltic pump (1) comprises a rotor with rollers, a mobile jaw having an open position and a closed position, and further comprises, on each side of the rotor, a locating member for said tube adapted to receive it when it is pressed in and to allow it to slide in the longitudinal direction in which the locating member extends, said locating members being disposed in a line between the rotor and the mobile jaw in the open position.
摘要翻译： 蠕动泵（1）包括具有滚子的转子，具有打开位置和闭合位置的移动夹爪，并且还包括在转子的每一侧上的用于所述管的定位构件，其适于在被压入时将其接收 并且允许其在定位构件延伸的纵向方向上滑动，所述定位构件在打开位置中以转子和可动夹爪之间的线设置。
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公开(公告)号：US20080090285A1
公开(公告)日：2008-04-17
申请号：US11805540
申请日：2007-05-23
申请人： Stephane Olivier
发明人： Stephane Olivier
摘要： The device for microbiological testing of a sample of liquid includes an envelope (11) and a filter membrane (3), said envelope (11) including a removable body (6) and means (4, 5) for supporting said membrane (3) in the wetted state; said supporting means (4, 5) including a sponge (5) and said removable body including a flexible wall (6) adapted to move toward said membrane (3), when said device is subjected to a reduced pressure and to return to its initial position when said reduced pressure ceases. The assembly includes a device of the above kind and a clamp adapted to grip the device in the manner of a vise. The method includes the step of obtaining such a device, of passing said sample between the inlet aperture and the outlet aperture of said device, of subjecting said device to a reduced pressure, of making said reduced pressure cease, and then of detecting the presence of microorganisms on the membrane of said device.
摘要翻译： 用于液体样本的微生物测试的装置包括外壳（11）和过滤膜（3），所述外壳（11）包括可拆卸体（6）和用于支撑所述膜（3）的装置（4,5） 处于潮湿状态; 所述支撑装置（4,5）包括海绵（5）和所述可移除主体，其包括适于朝向所述隔膜（3）移动的柔性壁（6），当所述装置经受减压并返回其初始 当所述减压停止时的位置。 组件包括上述类型的装置和适于以台钳的方式夹紧装置的夹具。 该方法包括获得这样的装置的步骤：使所述样品在所述装置的入口孔和出口孔之间通过，使所述装置减压，使所述减压停止，然后检测是否存在 所述装置的膜上的微生物。
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公开(公告)号：US20070207514A1
公开(公告)日：2007-09-06
申请号：US11704867
申请日：2007-02-09
申请人： Raphael Grinon , Stephane Olivier
发明人： Raphael Grinon , Stephane Olivier
CPC分类号： G01N21/763 , G01N35/10
摘要： The device includes means for holding a support (19) adapted to retain microorganisms in a predetermined position in which a first face (10) of said support (19) is in a first predetermined location and a second face (11) of said support (19) is in a second predetermined location, a station (2) for spraying onto said support (19) a reagent for revealing the presence of ATP by luminescence, said station (2) facing said first location, and a station (4) for measuring said luminescence opposite the spraying station and facing said second location. The method includes the step of procuring a device of the above kind, the step of disposing said support (19) at said predetermined location, the step of spraying said reagent onto said support (19) and, simultaneously with the spraying step, the step of measuring the quantity of light emitted in response to said reagent.
摘要翻译： 该装置包括用于保持适于将微生物保持在其中所述支撑件（19）的第一面（10）处于第一预定位置的预定位置和所述支撑件的第二面（11）的支撑件（19）的装置 19）位于第二预定位置，用于喷射到所述支撑件（19）上的用于通过发光显露ATP存在的试剂的站（2），所述站（2）面向所述第一位置，以及用于 测量与喷射站相对的所述发光并面对所述第二位置。 该方法包括获得上述装置的步骤，将所述支撑件（19）设置在所述预定位置的步骤，将所述试剂喷射到所述支撑件（19）上的步骤，并且在喷涂步骤的同时， 测量响应于所述试剂发射的光量。
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公开(公告)号：US20050051471A1
公开(公告)日：2005-03-10
申请号：US10655052
申请日：2003-09-04
申请人： Joseph Lane , Louis Bonhomme , Douglas Boucher , Richard Burnham , Kenneth Desilets , Luc Lirot , Stephane Olivier , Steven Sheridan
发明人： Joseph Lane , Louis Bonhomme , Douglas Boucher , Richard Burnham , Kenneth Desilets , Luc Lirot , Stephane Olivier , Steven Sheridan
CPC分类号： B01L3/50255 , B01L2300/0848
摘要： The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.
摘要翻译： 本发明提供了一种具有改进的喷口的暗渠。 缺水在单井和微阵列过滤装置的构建中具有特殊的用途。 在一个主要实施方案中，缺油的特征在于其结合了直壁的大致纹理的喷口，喷嘴在其末端处设置有微孔，用于排出通过漏斗传导的流体。 包括若干这样的下水道的阵列可以与相应的孔阵列配合，其间设置有分离材料（例如膜材料）。 所得到的微阵列过滤装置可用于与例如良好的“悬滴”控制和低“串扰”同时进行几种流体测定。
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