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    Spectroscopic system and method using a ceramic optical reference
    12.
    发明授权
    Spectroscopic system and method using a ceramic optical reference 有权
    光谱系统和方法使用陶瓷光学参考

    公开(公告)号：US06956649B2

    公开(公告)日：2005-10-18

    申请号：US10723353

    申请日：2003-11-25

    申请人： George M. Acosta ,  Kevin H. Hazen ,  N. Alan Abul-Haj ,  Stephen L. Monfre ,  Thomas B. Blank

    发明人： George M. Acosta ,  Kevin H. Hazen ,  N. Alan Abul-Haj ,  Stephen L. Monfre ,  Thomas B. Blank

    IPC分类号： G01N21/27 ,  G01N21/47 ,  G01N21/49 ,  G01J3/28

    CPC分类号： G01N21/278 ,  G01N21/4738 ,  G01N21/4785 ,  G01N21/49 ,  G01N2021/4735

    摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.

    摘要翻译： 介绍了陶瓷参考文献，结合光谱仪，金属化陶瓷材料以及在紫外线，可见光，近红外或红外光谱区域中利用陶瓷材料作为参考的方法。 优选实施例利用陶瓷参考材料将入射光源漫反射到检测器元件，以便以可再现的方式进行定量。 替代实施例将入射表面或后表面金属化以形成表面漫反射标准。 可选的波长参考层或保护层可以添加到陶瓷或金属化层。 参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪的光信号测量。

    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM
    14.
    发明申请
    METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
    葡萄糖代谢障碍筛查方法

    公开(公告)号：US20090098587A1

    公开(公告)日：2009-04-16

    申请号：US12099740

    申请日：2008-04-08

    申请人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    发明人： Donald Hetzel ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  Linda Hockersmith ,  Andrew Cone

    IPC分类号： C12Q1/54

    CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/7264 ,  G01N33/66 ,  G01N2800/042 ,  G16H50/20 ,  G16H50/70

    摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.

    摘要翻译： 筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。 数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。 构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。 该方法在被编程为执行该方法的步骤的处理装置上执行。 根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。

    Fiber optic probe placement guide
    16.
    发明授权
    Fiber optic probe placement guide 失效
    光纤探头放置指南

    公开(公告)号：US06415167B1

    公开(公告)日：2002-07-02

    申请号：US09563782

    申请日：2000-05-02

    申请人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Stephen L. Monfre

    发明人： Thomas B. Blank ,  George Acosta ,  Mutua Mattu ,  Stephen L. Monfre

    IPC分类号： A61B500

    CPC分类号： A61B5/0059 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6824 ,  A61B2562/12 ,  A61B2562/146

    摘要： A fiber optic probe placement guide minimizes sampling errors during optical sampling of a tissue measurement site by allowing repeatable placement of the fiber optic probe at a targeted tissue measurement site. A mount, contoured to conform to the shape of the tissue measurement site, typically the arm of a human subject, contains an aperture for receiving a fiber optic probe. A temperature probe on the contact surface of the guide allows for monitoring of surface temperature within the vicinity of the tissue measurement site. Crosshair slots in the mount align with corresponding crosshairs at the tissue measurement site. The fiber optic probe placement guide is affixed to the tissue measurement site by means of adhesive tape or fastenable straps. Guideposts on the external surface of the mount are received by corresponding receptacles on a subject interface bearing the fiber optic probe to facilitate alignment of the fiber optic probe with the aperture.

    摘要翻译： 光纤探针放置导向器通过允许将光纤探针重复放置在目标组织测量部位来最小化组织测量部位的光学采样期间的采样误差。 通常是组织测量部位的形状，通常是人体受试者的臂的形状的安装件包含用于接收光纤探针的孔。 引导件的接触表面上的温度探头允许监测组织测量部位附近的表面温度。 安装座上的十字准线槽与组织测量部位的相应十字准线对齐。 光纤探针放置导板通过胶带或可固定带固定在组织测量部位。 安装座外表面上的导轨由承载光纤探头的主体接口上的​​相应插座接收，以便光纤探头与孔径对准。

    Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination
    18.
    发明授权
    Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination 有权
    用于最小化归因于基于NIR的非侵入性血液分析物测定期间的组织状态变化的光谱效应的方法和装置

    公开(公告)号：US06640117B2

    公开(公告)日：2003-10-28

    申请号：US09955531

    申请日：2001-09-17

    申请人： Marcy R. Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    发明人： Marcy R. Makarewicz ,  Mutua Mattu ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    IPC分类号： A61B500

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1491

    摘要： A method and apparatus for minimizing confounding effects in a noninvasive in-vivo spectral measurement caused by fluctuations in tissue state monitors a selected tissue state parameter spectroscopically and maintains the selected parameter within a target range, at which spectral effects attributable to the changes in the selected parameter are minimized. The invention includes both active and passive control. A preferred embodiment of the invention provides a method and apparatus for minimizing the confounding effects in near IR spectral measurements attributable to shifts in skin temperature at a tissue measurement site. Spectroscopic monitoring of skin temperature at the measurement site provides near-instantaneous temperature readings by eliminating thermal time constants. A thermistor positioned at the measurement site provides active control. The spectrometer and the temperature control device are incorporated into a single instrument for noninvasive measurement of blood glucose concentration.

    摘要翻译： 用于最小化由组织状态的波动引起的非侵入性体内光谱测量中的混杂效应的方法和装置通过光谱方式监测所选择的组织状态参数，并将所选择的参数保持在目标范围内，在该范围内，归因于所选择的变化的光谱效应 参数最小化。 本发明包括主动和被动控制。 本发明的一个优选实施例提供了一种方法和装置，用于最小化归因于组织测量部位的皮肤温度变化的近红外光谱测量中的混杂效应。 光谱监测测量点的皮肤温度通过消除热时间常数提供近乎瞬时的温度读数。 位于测量位置的热敏电阻提供主动控制。 光谱仪和温度控制装置被并入单个仪器中用于非侵入性测量血糖浓度。

    Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction
    19.
    发明授权
    Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 有权
    开发用于非侵入性血液分析物预测的局部校准模型的多层方法

    公开(公告)号：US06512937B2

    公开(公告)日：2003-01-28

    申请号：US09825687

    申请日：2001-04-03

    申请人： Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Suresh Thennadil

    发明人： Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti ,  Suresh Thennadil

    IPC分类号： A61B500

    CPC分类号： G01N21/274 ,  A61B5/1075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  A61B2560/0233 ,  G01N21/359 ,  G01N21/4785 ,  G01N21/49 ,  Y10S128/92

    摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.

    摘要翻译： 非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。 组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。 多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。 在每个层次中，使用主体人口统计学，光谱测量信息和适合于开发组织分类的其他设备测量来连续地改进类别。多层分类校准方法利用多变量统计学参数和使用光谱特征的多层次分类。 用于多层分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。 使用沿关键波长段的NIR光谱信号评估所有组织参数。

    Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor
    20.
    发明授权
    Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor 失效

    公开(公告)号：US06487429B2

    公开(公告)日：2002-11-26

    申请号：US09766872

    申请日：2001-01-18

    申请人： Linda Hockersmith ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    发明人： Linda Hockersmith ,  Thomas B. Blank ,  Stephen L. Monfre ,  Timothy L. Ruchti

    IPC分类号： A61B500

    CPC分类号： A61B5/14532

    摘要： A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.