公开(公告)号：US20110171269A1

公开(公告)日：2011-07-14

申请号：US12990540

申请日：2009-04-30

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

IPC分类号： A61K9/00 ,  A61K31/235 ,  A61P1/16 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： A61K9/1652 ,  A61K9/5153 ,  A61K31/235 ,  A61K31/343 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/585 ,  A61K31/704 ,  A61K31/7048 ,  B01D65/00 ,  C08J3/03 ,  Y10S516/929

摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.

摘要翻译： 本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤 极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。 本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒 可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。 本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。

公开(公告)号：US20110020225A1

公开(公告)日：2011-01-27

申请号：US12672517

申请日：2008-08-05

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jung Hyun Han

IPC分类号： A61K49/00 ,  A61K9/14 ,  A61P31/00

CPC分类号： A61K9/5031 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0089 ,  C08J3/12 ,  C08J2367/04

摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.

摘要翻译： 本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。 根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。 此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

公开(公告)号：US20100228237A1

公开(公告)日：2010-09-09

申请号：US12376792

申请日：2007-07-30

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim

IPC分类号： A61B18/20 ,  B05D5/12 ,  B05D7/00 ,  B82B3/00 ,  C22C5/02 ,  B32B1/00

CPC分类号： G01N33/5434 ,  B82Y25/00 ,  H01F1/0054 ,  Y10T428/2913 ,  Y10T428/2982 ,  Y10T428/2991

摘要： The present invention relates to gold nanocages containing magnetic nanoparticles and a preparation method thereof. More specifically, relates to hollow-type gold nanocage particles, which contain iron oxide nanoparticles having a magnetic property and have an optical property of strongly absorbing or scattering light in the near-infrared (NIR) region, as well as a preparation method thereof. Due to their optical property and magnetic property, the magnetic nanoparticle-containing gold nanocages can be used in various applications, including analysis in a turbid medium with light, cancer therapy or biomolecular manipulation using light, contrast agents for magnetic resonance imaging, magnetic hyperthermia treatment and drug delivery guide, etc.

摘要翻译： 本发明涉及含有磁性纳米颗粒的金纳米颗粒及其制备方法。 更具体地说，涉及含有具有磁性能并具有在近红外（NIR）区域中强吸收或散射光的光学性质的氧化铁纳米粒子的中空型金纳米颗粒及其制备方法。 由于磁性纳米颗粒的光学性质和磁性，可以在各种应用中使用含有磁性纳米颗粒的金纳米颗粒，包括在具有光的混浊介质，癌症治疗或使用光的生物分子操作，磁共振成像造影剂，磁疗热疗 药物传递指南等

公开(公告)号：US09623121B2

公开(公告)日：2017-04-18

申请号：US13885126

申请日：2011-11-18

申请人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee

发明人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee

IPC分类号： A61B5/055 ,  A61K49/00 ,  G01N21/64

CPC分类号： A61K49/0054 ,  A61K49/0034 ,  A61K49/0056 ,  G01N21/6428 ,  G01N21/6456

摘要： The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination.

公开(公告)号：US20140170077A1

公开(公告)日：2014-06-19

申请号：US14110138

申请日：2011-04-07

申请人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

发明人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

IPC分类号： A61K49/12

CPC分类号： A61K49/126 ,  A61K49/1863 ,  A61K49/1872

摘要： The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.

摘要翻译： 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。

公开(公告)号：US08753606B2

公开(公告)日：2014-06-17

申请号：US13000197

申请日：2009-06-19

申请人： Bong Hyun Chung ,  Yong Taik Lim

发明人： Bong Hyun Chung ,  Yong Taik Lim

IPC分类号： A61K49/00

CPC分类号： A61K49/0078 ,  A61K49/0002 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/1806

摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

摘要翻译： 本发明涉及使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳组成的纳米乳液用于多光谱磁共振成像（MRI）和 用于多色荧光检测的纳米颗粒。 在多模式成像方法中，通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合，可以获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。 因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

公开(公告)号：US20090022765A1

公开(公告)日：2009-01-22

申请号：US11995847

申请日：2006-02-13

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim ,  Jin Young Jeong ,  Tai Hwan Ha

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Jin Kyeong Kim ,  Jin Young Jeong ,  Tai Hwan Ha

IPC分类号： A61K8/19 ,  A61K8/00 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/10

CPC分类号： B82Y5/00 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/8176 ,  A61K2800/413 ,  A61Q1/02 ,  A61Q1/06

摘要： The present invention relates to a cosmetic pigment composition exhibiting colors in the visible region, which comprises an effective amount of nanoparticles or a mixture of two or more nanoparticles selected from the group consisting of (a) gold nanoparticles exhibiting red color; (b) silver nanoparticles exhibiting yellow color; (c) gold-silver alloy nanoparticles exhibiting flame color; and (d) gold nanoparticles exhibiting blue color, and a color cosmetic composition and a color lotion comprising the pigment composition. According to the present invention, it is possible to prepare pigments exhibiting various colors in the visible region using gold or silver nanoparticles, and a cosmetic pigment composition which can exhibit various colors by mixing the pigments in various compositional ratios, in which precipitation or agglomeration of particles does not occur, and whose color can be maintained for a long time. Also, since the pigment of the present invention is not harmful to the human body unlike conventional metal pigments, and contains gold or silver that is beneficial to health, the pigment can be used in various applications as functional raw materials.

摘要翻译： 本发明涉及一种在可见光区域显示颜色的化妆品颜料组合物，其包含有效量的纳米颗粒或选自（a）显示红色的金纳米颗粒的两种或更多种纳米颗粒的混合物; （b）呈现黄色的银纳米颗粒; （c）显示火焰色的金 - 银合金纳米颗粒; 和（d）显示蓝色的金纳米颗粒，以及着色化妆品组合物和包含该颜料组合物的色乳液。 根据本发明，可以使用金或银纳米颗粒制备在可见区域中显示各种颜色的颜料，以及可以通过以各种组成比混合颜料来显示各种颜色的化妆品颜料组合物，其中沉淀或聚集 颗粒不会发生，并且其颜色可以长时间保持。 此外，由于本发明的颜料与常规金属颜料不同，对人体无害，并且含有有益于健康的金或银，所以颜料可用作各种用途的功能性原料。

公开(公告)号：US09138491B2

公开(公告)日：2015-09-22

申请号：US14110138

申请日：2011-04-07

申请人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

发明人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

IPC分类号： A61K49/12 ,  A61B5/055 ,  A61K49/18

CPC分类号： A61K49/126 ,  A61K49/1863 ,  A61K49/1872

摘要： The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.

摘要翻译： 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。

公开(公告)号：US08734762B2

公开(公告)日：2014-05-27

申请号：US12738394

申请日：2008-08-20

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61K9/66

CPC分类号： C09K11/565 ,  C09K11/02 ,  C09K11/883

摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.

摘要翻译： 本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能 量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。 所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。 因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。

公开(公告)号：US20100233094A1

公开(公告)日：2010-09-16

申请号：US12738394

申请日：2008-08-20

申请人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

发明人： Bong Hyun Chung ,  Yong Taik Lim ,  Bang Sil Choi ,  Jung Hyun Han

IPC分类号： A61B5/055

CPC分类号： C09K11/565 ,  C09K11/02 ,  C09K11/883

摘要： The present invention relates to a perfluorocarbon nanoemulsion containing quantum dot nanoparticles and a method for preparing the same, more specifically, relates to a method for preparing a multifunctional perfluorocarbon nanoemulsion which simultaneously shows the fluorine-based magnetic resonance properties of perfluorocarbon and the optical properties of quantum dot nanoparticles, the method comprising dispersing quantum dot nanoparticles, modified with a fluorine end group, in perfluorocarbon, and then adding an aqueous emulsifier solution containing lipid to the dispersion. The disclosed perfluorocarbon nanoemulsion containing quantum dot nanoparticles has excellent biocompatibility and simultaneously shows optical properties and magnetic resonance properties, and thus can be used as a contrast agent for multi-mode molecular imaging. Accordingly, the nanoemulsion can be used to study cell and small-animal molecular imaging in various fields, including biological and medical fields.

摘要翻译： 本发明涉及含有量子点纳米粒子的全氟碳纳米乳液及其制备方法，更具体地涉及制备多功能全氟碳纳米乳液的方法，该方法同时显示全氟化碳的氟基磁共振性能和光学性能 量子点纳米粒子，该方法包括将用氟端基改性的量子点纳米粒子分散在全氟化碳中，然后向分散体中加入含有脂质的水性乳化剂溶液。 所公开的含有量子点纳米粒子的全氟化碳纳米乳液具有优异的生物相容性，并同时显示光学性质和磁共振性质，因此可用作多模式分子成像的造影剂。 因此，纳米乳液可用于研究包括生物和医学领域在内的各个领域的细胞和小动物分子成像。