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公开(公告)号：US06194139B1
公开(公告)日：2001-02-27
申请号：US09407814
申请日：1999-09-28
IPC分类号： A01N102
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4′, 5′, and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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12.发明授权Method for inactivation of pathogens in platelets using 4' and 5' primary amino-substituted psoralens 失效使用4'和5'伯氨基取代的补骨脂素使血小板中的病原体失活的方法
公开(公告)号：US6004742A
公开(公告)日：1999-12-21
申请号：US962903
申请日：1997-11-03
CPC分类号： A61K41/0066 , A01N1/0215 , A01N1/0294 , A61K31/37 , A61L2/0011 , A61L2/0088
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic add of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. In particular compounds with primary aminoalkyl substitutions on the 4' or 5' positions of psoralen are used to inactivate pathogens in blood products such as platelets.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体的核酸添加结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。 特别是在补骨脂素的4'或5'位上具有伯氨基烷基取代的化合物用于灭活血液制品如血小板中的病原体。
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13.发明授权5'-(4-amino-2-oxa)butye-4,4', 8-trinethylpsoralen in synthetic medium 失效5' - （4-氨基-2-氧杂）丁基-4,4'，8-三乙基肌醇在合成培养基
公开(公告)号：US5712085A
公开(公告)日：1998-01-27
申请号：US465148
申请日：1995-06-05
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/02 , A01N1/0205 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4,4',5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion. Also disclosed are compositions comprising 4' or 5'-primary amino substituted psoralens in a synthetic media.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。 还公开了在合成培养基中包含4'或5'-主要氨基取代的补骨脂素的组合物。
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公开(公告)号：US5556993A
公开(公告)日：1996-09-17
申请号：US465495
申请日：1995-06-05
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/02 , A01N1/0205 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4,4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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15.发明授权Method for inactivating pathogens in blood using photoactivation of 4'-primary amino-substituted psoralens 失效使用4'-伯氨基取代的补骨脂素的光活化来灭活血液中的病原体的方法
公开(公告)号：US5593823A
公开(公告)日：1997-01-14
申请号：US337987
申请日：1994-11-14
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C12N7/06
CPC分类号： C07D493/04 , A01N1/0215 , A01N1/0294 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.
摘要翻译： 合成补骨脂素化合物，其在补骨脂素的4,4'，5'和8位上具有取代，其允许增强与病原体核酸的结合。 描述了更高的补骨脂素结合水平和较低的致突变性，导致血液制品中病原体的更安全，更有效和可靠的失活。 本发明考虑使用新的补骨脂素的灭活方法，其不损害用于输血的血液制品的功能。
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公开(公告)号：US5578736A
公开(公告)日：1996-11-26
申请号：US456205
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/02
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
摘要翻译： 合成补骨脂素化合物组合物，其在补骨脂素的4,4'，5'和8位上具有取代，其仍然允许它们与病原体的核酸结合。 激活这些结合的补骨脂素的反应条件导致与核酸的共价交联，从而使病原体灭活。 更高的补骨脂素结合水平和较低的致突变性导致更安全，更有效和可靠的病原体失活。 除了补骨脂素组合物之外，本发明考虑使用新的补骨脂素的灭活方法。
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公开(公告)号：US5625079A
公开(公告)日：1997-04-29
申请号：US462377
申请日：1995-06-05
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/02 , A01N1/0205 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Synthesis of 4,8-dialkyl-4'-bromomethyl-5'-methylpsoralen and 4,8-dialkyl-5'-bromomethyl-4'-methylpsoralen compounds useful as intermediates.
摘要翻译： 用作中间体的4,8-二烷基-4'-溴甲基-5'-甲基睾丸激素和4,8-二烷基-5'-溴甲基-4'-甲基脯氨酸化合物的合成。
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公开(公告)号：US5585503A
公开(公告)日：1996-12-17
申请号：US455053
申请日：1995-05-31
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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公开(公告)号：US5399719A
公开(公告)日：1995-03-21
申请号：US83459
申请日：1993-06-28
IPC分类号： A01N1/02 , A61K31/365 , A61K31/37 , A61K35/14 , A61K41/00 , A61L2/00 , C07D493/04 , C07D493/00
CPC分类号： C07D493/04 , A01N1/0215 , A61K31/365 , A61K31/37 , A61K41/0019 , A61K41/0066 , A61L2/0011
摘要： Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.
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公开(公告)号：US5532146A
公开(公告)日：1996-07-02
申请号：US263020
申请日：1994-06-20
IPC分类号： B01L7/00 , C07D311/18 , C07D493/04 , C07D519/00 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70
CPC分类号： C07D493/04 , B01L7/00 , B01L7/52 , C07D311/18 , C07H21/00 , C12N15/10 , C12P19/34 , C12Q1/6848 , Y10S435/81
摘要： Methods for sterilization of ligase-based amplification products, including products of the Ligation Amplification Reaction (LAR), involving treatment of nucleic acid after amplification to render such nucleic acid incapable of serving as a template for further amplification. Both random and site-specific addition of sterilizing compounds, and more specifically, photoactivation compounds, render amplification product subsequently unamplifiable. Self-sterilizing primers are also employed allowing for a homogenous detection of ligase-based amplification product.
摘要翻译： 连接酶扩增产物的灭菌方法，包括连接扩增反应（LAR）的产物，涉及在扩增后处理核酸，使得这种核酸不能作为进一步扩增的模板。 杀菌化合物，特别是光活化化合物的随机和位点特异性添加使随后的扩增产物不可扩增。 还使用自消毒引物，允许基于连接酶的扩增产物的均匀检测。
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