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公开(公告)号：US08158400B2
公开(公告)日：2012-04-17
申请号：US13294047
申请日：2011-11-10
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
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12.发明申请公开(公告)号：US20120058930A1
公开(公告)日：2012-03-08
申请号：US13294047
申请日：2011-11-10
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有脂肪酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。
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公开(公告)号：US07662602B2
公开(公告)日：2010-02-16
申请号：US11255553
申请日：2005-10-21
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
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公开(公告)号：US20060075518A1
公开(公告)日：2006-04-06
申请号：US11241677
申请日：2005-09-30
申请人： Debbie Yaver , Suzanne Otani , Haiyan Ge , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Haiyan Ge , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Patkar , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20 , C12Y301/01003
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
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15.发明申请公开(公告)号：US20080020425A1
公开(公告)日：2008-01-24
申请号：US11255553
申请日：2005-10-21
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有脂肪酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及核酸构建体，载体，和包含所述多核苷酸的宿主细胞以及方法用于产生和使用所述多肽。
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公开(公告)号：US20110224123A1
公开(公告)日：2011-09-15
申请号：US13114258
申请日：2011-05-24
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Chritopher Amolo , Kim Borch , Shamkant Anant , Michael Lamsa , Barbara Cherry
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译： 本发明涉及具有脂肪酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及核酸构建体，载体，和包含所述多核苷酸的宿主细胞以及方法用于产生和使用所述多肽。
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公开(公告)号：US08187854B2
公开(公告)日：2012-05-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。
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公开(公告)号：US20090029440A1
公开(公告)日：2009-01-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。
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公开(公告)号：US20070179074A1
公开(公告)日：2007-08-02
申请号：US11656254
申请日：2007-01-22
申请人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
发明人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to detergent compositions comprising a detergent ingredient and a lipase variant with reduced potential for odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明涉及洗涤剂组合物，其包含洗涤剂成分和通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味生成潜力的脂肪酶变体。
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公开(公告)号：US08273348B2
公开(公告)日：2012-09-25
申请号：US12519868
申请日：2007-12-12
申请人： Allan Svendsen , Michael Skjoet , Debbie Yaver , Lars Lehmann Hylling Christensen , Signe Eskildsen Larsen , Nina Lundin , Michael Lamsa , Peter Colin Gregory
发明人： Allan Svendsen , Michael Skjoet , Debbie Yaver , Lars Lehmann Hylling Christensen , Signe Eskildsen Larsen , Nina Lundin , Michael Lamsa , Peter Colin Gregory
IPC分类号： A61K38/54 , A61K38/46 , C12Q1/34 , C12Q1/40 , C12N9/20 , C12N9/14 , C12N9/26 , C07H21/04 , C07K1/00
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , C12N9/20
摘要： The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, an are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.
摘要翻译： 与包含SEQ ID NO：2的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶具有例如体外改进的消化性能，在中性范围内的pH值改善的活性，在低pH下的改进的稳定性，对蛋白酶降解是稳定的，和/或在存在时是稳定的 的胃蛋白酶和胆汁盐。 本发明还涉及确定脂肪酶的体外消化性能的方法以及T.lanuginosus的脂肪酶的某些新颖变体。
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