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公开(公告)号：US08187854B2
公开(公告)日：2012-05-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。
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公开(公告)号：US20090029440A1
公开(公告)日：2009-01-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。
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公开(公告)号：US20090217463A1
公开(公告)日：2009-09-03
申请号：US12393115
申请日：2009-02-26
申请人： Philip Frank Souter , Neil Joseph Lant , Theresa Clare Haynes , Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen
发明人： Philip Frank Souter , Neil Joseph Lant , Theresa Clare Haynes , Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen
CPC分类号： C12N9/20 , C11D3/38627
摘要： This invention relates to compositions comprising certain lipase enzymes and processes for making and using such compositions, including the use of such compositions to clean and/or treat a situs.
摘要翻译： 本发明涉及包含某些脂肪酶的组合物和制备和使用这些组合物的方法，包括使用这种组合物来清洁和/或治疗部位。
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4.发明申请公开(公告)号：US20090221033A1
公开(公告)日：2009-09-03
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译： 本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。 令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。
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5.发明授权公开(公告)号：US07919298B2
公开(公告)日：2011-04-05
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译： 本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。 令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。
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公开(公告)号：US20070179074A1
公开(公告)日：2007-08-02
申请号：US11656254
申请日：2007-01-22
申请人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
发明人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to detergent compositions comprising a detergent ingredient and a lipase variant with reduced potential for odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明涉及洗涤剂组合物，其包含洗涤剂成分和通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味生成潜力的脂肪酶变体。
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7.发明申请公开(公告)号：US20100227375A1
公开(公告)日：2010-09-09
申请号：US12762586
申请日：2010-04-19
CPC分类号： C12N9/20
摘要： The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.
摘要翻译： 本发明涉及具有脂肪酶活性的多肽，并且在说明书中给出的测试条件下进一步具有至少0.8的RP和至少1.1的BR。
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公开(公告)号：US07282233B2
公开(公告)日：2007-10-16
申请号：US11214188
申请日：2005-08-29
IPC分类号： A21D10/00
CPC分类号： C11D3/38627 , C12N9/20
摘要： Lipolytic enzymes are chemically modified by covalently linking one or more (particularly 1-3) hydrophobic groups to the enzyme molecule. The chemical modification improves the performance of the lipolytic enzyme, e.g., in baking or in detergents.
摘要翻译： 通过将一个或多个（特别是1-3个）疏水基团共价连接到酶分子上来对脂肪分解酶进行化学修饰。 化学修饰改善了脂肪分解酶的性能，例如在烘烤中或在洗涤剂中。
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公开(公告)号：US08679774B2
公开(公告)日：2014-03-25
申请号：US12849911
申请日：2010-08-04
申请人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schroder Glad , Gitte Budolfsen
发明人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schroder Glad , Gitte Budolfsen
CPC分类号： C12Y301/01003 , A21D8/042 , C11B3/003 , C11D3/38627 , C12N9/20 , C12P9/00
摘要： The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.
摘要翻译： 可以通过改变脂肪分解酶的限定区域中的氨基酸序列来修饰脂解酶的底物特异性，从而增加所需活性的水平或降低不需要的活性的水平。 因此，本发明人已经开发了具有修饰的氨基酸序列的脂肪分解酶变体，其具有底物特异性，其可以针对特定用途进行定制。
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公开(公告)号：US20100105092A1
公开(公告)日：2010-04-29
申请号：US12443625
申请日：2007-10-02
申请人： Allan Svendsen , Jesper Vind , Shamkant Anant Patkar , Kim Borch
发明人： Allan Svendsen , Jesper Vind , Shamkant Anant Patkar , Kim Borch
CPC分类号： C12N9/20 , C07K2299/00
摘要： Variants with increased acyl transferase activity can be designed on the basis of a three-dimensional model by making amino acid alterations near the active Ser of lipolytic enzymes such as C. antarctica lipase A or the lipase/acyl transferase from C. parapsilosis.
摘要翻译： 具有增加的酰基转移酶活性的变体可以在三维模型的基础上通过在脂肪分解酶如南极洲洲油脂酶A或来自副杆菌病的脂肪酶/酰基转移酶的活性Ser附近进行氨基酸改变来设计。
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