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公开(公告)号：US20070020381A1
公开(公告)日：2007-01-25
申请号：US11527893
申请日：2006-09-26
申请人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
IPC分类号： A61L33/00
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
摘要翻译： 公开了一种用于降低活性剂从可植入装置（例如支架）的释放速率的方法和涂层。
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公开(公告)号：US20070026131A1
公开(公告)日：2007-02-01
申请号：US11527826
申请日：2006-09-26
申请人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
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公开(公告)号：US20070020382A1
公开(公告)日：2007-01-25
申请号：US11527971
申请日：2006-09-26
申请人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed Hossainy , Gordon Stewart , Mark Williams , Jeff Royal , Paul Consigny , Dorie Happ , Kurt Scheinpflug , Ty Hu
IPC分类号： A61L33/00
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method and coating for reducing the release rate of an active agent from an implantable device, such as a stent, is disclosed.
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14.发明申请Design of poly(ester amides) for the control of agent-release from polymeric compositions 审中-公开聚（酯酰胺）的设计，用于控制聚合物组合物释放的药剂公开(公告)号：US20050288481A1
公开(公告)日：2005-12-29
申请号：US11187467
申请日：2005-07-22
申请人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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公开(公告)号：US08936780B2
公开(公告)日：2015-01-20
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785 , A61F2/00 , A61K9/00 , A61L24/00 , A61L24/04
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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16.发明授权Poly(ester amides) for the control of agent-release from polymeric compositions 有权用于控制聚合物组合物释放试剂的聚（酯酰胺）公开(公告)号：US08815274B2
公开(公告)日：2014-08-26
申请号：US12478693
申请日：2009-06-04
申请人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F. A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预先设计以提供来自医药制品的试剂组合的预定释放速率的设计。
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17.发明申请Dual Drug Formulations For Implantable Medical Devices For Treatment of Vascular Diseases 审中-公开用于治疗血管疾病的可植入医疗器械的双重药物制剂公开(公告)号：US20090104240A1
公开(公告)日：2009-04-23
申请号：US11875723
申请日：2007-10-19
申请人： Gordon Stewart , Syed F.A. Hossainy , Benjamyn Serna , Mikael Trollsas , Jessica R. Desnoyer , Leslie Coleman , Gina Zhang , Maricela Kezis
发明人： Gordon Stewart , Syed F.A. Hossainy , Benjamyn Serna , Mikael Trollsas , Jessica R. Desnoyer , Leslie Coleman , Gina Zhang , Maricela Kezis
CPC分类号： A61K31/573 , A61F2250/0068 , A61K31/436 , A61K31/56 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45
摘要： The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases.
摘要翻译： 本发明涉及涂覆有至少含有极性的聚合物和用于治疗血管疾病的皮质类固醇的可植入医疗装置。
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公开(公告)号：US20080057024A1
公开(公告)日：2008-03-06
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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19.发明申请POLY(ESTER AMIDES) FOR THE CONTROL OF AGENT-RELEASE FROM POLYMERIC COMPOSITIONS 有权POLY（ESTER AMIDES）用于控制聚合物组合物的发行公开(公告)号：US20090297583A1
公开(公告)日：2009-12-03
申请号：US12478693
申请日：2009-06-04
申请人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61K9/00 , A61K31/765 , A61P9/10
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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公开(公告)号：US20120231049A1
公开(公告)日：2012-09-13
申请号：US13481515
申请日：2012-05-25
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括将湿或干涂层暴露于冻融循环。 涂层可用于控制递送活性剂或活性剂的组合。
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