公开(公告)号：US20080113207A1

公开(公告)日：2008-05-15

申请号：US12016811

申请日：2008-01-18

Applicant: Stephen Pacetti ,  Syed Hossainy ,  Yiwen Tang ,  Andrew Tung ,  Thierry Glauser

Inventor： Stephen Pacetti ,  Syed Hossainy ,  Yiwen Tang ,  Andrew Tung ,  Thierry Glauser

IPC: B32B27/08 ,  B32B27/00

CPC classification number: A61L31/10 ,  A61F2250/0067 ,  A61L2420/08 ,  Y10T428/24942 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31565 ,  Y10T428/31573 ,  Y10T428/31576 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/31928 ,  Y10T428/31935

Abstract: A coating for an implantable medical device is provided comprising a first layer including a first polymer and a second layer including a second polymer. The second layer is disposed over at least a portion of the first layer. The second polymer has a lower degree of hydration than the first polymer.

Abstract translation: 提供了一种用于可植入医疗装置的涂层，包括包含第一聚合物的第一层和包含第二聚合物的第二层。 第二层设置在第一层的至少一部分上。 第二聚合物的水合度比第一聚合物低。

公开(公告)号：US20080107795A1

公开(公告)日：2008-05-08

申请号：US12014029

申请日：2008-01-14

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: B05D1/02

CPC classification number: B05D1/34 ,  B05B13/0228 ,  B05D1/002 ,  B05D1/02

Abstract: An apparatus for coating implantable medical devices, such as stents, and a method of coating stents using the apparatus is also disclosed. The apparatus includes a barrier or barriers for isolating an area of the stent on which a composition for coating a stent is applied. Two coating compositions can be applied simultaneously to a stent by separate nozzles on different sides of a barrier. Cross-contamination of the compositions is prevented by the barrier.

Abstract translation: 还公开了一种用于涂覆诸如支架的可植入医疗装置的装置以及使用该装置涂覆支架的方法。 该装置包括用于隔离其上应用用于涂覆支架的组合物的支架的区域的屏障或障碍物。 两个涂层组合物可以通过在屏障的不同侧面上的分开的喷嘴同时施用于支架。 通过屏障防止组合物的交叉污染。

公开(公告)号：US20080014332A1

公开(公告)日：2008-01-17

申请号：US11776448

申请日：2007-07-11

Applicant: Daniel Castro ,  Steven Wu ,  Kevin Woolbright ,  Kurt Scheinpflug ,  Syed Hossainy ,  Li Chen

Inventor： Daniel Castro ,  Steven Wu ,  Kevin Woolbright ,  Kurt Scheinpflug ,  Syed Hossainy ,  Li Chen

IPC: A61L33/00

CPC classification number: A61L31/16 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L2300/606 ,  B05D1/002 ,  B05D1/26 ,  B05D1/40 ,  B05D3/107

Abstract: A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed Additionally, an apparatus for forming the patterned coating is disclosed.

Abstract translation: 公开了一种假体上的图案化涂层，例如支架，以及用于形成涂层的方法。另外，公开了一种用于形成图案化涂层的装置。

公开(公告)号：US20080014240A1

公开(公告)日：2008-01-17

申请号：US11827912

申请日：2007-07-12

Applicant: David Gale ,  Syed Hossainy ,  Bin Huang

Inventor： David Gale ,  Syed Hossainy ,  Bin Huang

IPC: A61F2/82 ,  A61F2/06 ,  C08G63/08

CPC classification number: C08L67/04 ,  A61L31/10 ,  C08L101/00 ,  C08L2203/02 ,  C08L2205/02 ,  C08L2205/03 ,  C08L2666/18 ,  C08L2666/02

Abstract: The present invention relates to a composition of a first single enantiomer homopolymer and a separate stereocomplex formed of a second single enantiomer homopolymer and it mirror image enantiomer, wherein the first and second single enantiomer homopolymers can be the same or different.

Abstract translation: 本发明涉及第一单一对映异构体均聚物和由第二单一对映异构体均聚物及其镜像对映异构体形成的单独立体络合物的组合物，其中第一和第二单一对映异构体均聚物可以相同或不同。

公开(公告)号：US20070202323A1

公开(公告)日：2007-08-30

申请号：US11365392

申请日：2006-02-28

Applicant: Lothar Kleiner ,  Jessica DesNoyer ,  Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy

Inventor： Lothar Kleiner ,  Jessica DesNoyer ,  Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy

IPC: B05D3/00 ,  B05D7/00

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/422 ,  A61L2300/606 ,  Y10T428/265 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938 ,  C08L29/04

Abstract: A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.

Abstract translation: 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。

公开(公告)号：US20070098758A1

公开(公告)日：2007-05-03

申请号：US11641250

申请日：2006-12-18

Applicant: Syed Hossainy ,  Eugene Michal ,  Yiwen Tang

Inventor： Syed Hossainy ,  Eugene Michal ,  Yiwen Tang

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/606 ,  C08L67/04 ,  C08L71/02

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.

公开(公告)号：US20070065478A1

公开(公告)日：2007-03-22

申请号：US11601388

申请日：2006-11-17

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/252 ,  A61L2420/08

Abstract: Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes polycationic peptides, for example R7.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法。 涂层包括聚阳离子肽，例如R7。

公开(公告)号：US20070005130A1

公开(公告)日：2007-01-04

申请号：US11171111

申请日：2005-06-29

Applicant: Thierry Glauser ,  Syed Hossainy

Inventor： Thierry Glauser ,  Syed Hossainy

IPC: A61F2/82 ,  A61K47/12

CPC classification number: C08G63/06 ,  A61L31/10 ,  A61L31/148 ,  C08G2261/126 ,  C08L67/04

Abstract: Copolymer that includes units derived from malolactonate or malolactonic acid and coatings or medical devices formed thereof are provided.

Abstract translation: 提供了包含来源于丙二酸或异乳糖酸的单元和由其形成的涂层或医疗装置的共聚物。

公开(公告)号：US20070003589A1

公开(公告)日：2007-01-04

申请号：US11355870

申请日：2006-02-15

Applicant: Irina Astafieva ,  Thierry Glauser ,  Syed Hossainy

Inventor： Irina Astafieva ,  Thierry Glauser ,  Syed Hossainy

IPC: A61K48/00 ,  A61K31/4745 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/40 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2300/626 ,  C08L89/00

Abstract: Provided herein is a coating that includes a chemo-attractant for endothelial cells and methods of making and using the same.

Abstract translation: 本文提供的是包含内皮细胞的化学引诱剂的涂层及其制备和使用方法。

公开(公告)号：US20060286287A1

公开(公告)日：2006-12-21

申请号：US11509977

申请日：2006-08-25

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61L33/00 ,  B05D3/00

CPC classification number: B05B3/1014 ,  A61F2/82 ,  B05B3/001 ,  B05B13/0228 ,  Y10S118/16

Abstract: A method of coating a medical device, such as a stent is provided. The method can include forming a polymer layer containing a drug on the device, applying a polymer melt free from any solvents to the polymer layer to form a topcoat layer, wherein the during the application of the polymer melt the migration of the drug from the polymer layer is prevented or significantly minimized.