公开(公告)号：US10550129B2

公开(公告)日：2020-02-04

申请号：US16381163

申请日：2019-04-11

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10357484B2

公开(公告)日：2019-07-23

申请号：US15745290

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Masaki Daini ,  Hiroshi Nara ,  Masato Yoshikawa ,  Naoki Ishii ,  Masashi Toyofuku ,  Kousuke Hidaka

IPC: A61P25/28 ,  A61K31/427 ,  A61K31/437 ,  A61K31/444 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4035 ,  A61K31/4245 ,  A61K31/4439

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10081624B2

公开(公告)日：2018-09-25

申请号：US15506380

申请日：2015-08-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Naoki Ishii ,  Hiroshi Nara ,  Masato Yoshikawa ,  Masaki Daini ,  Masashi Toyofuku ,  Kousuke Hidaka

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D513/04

CPC classification number: C07D413/12 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D513/04

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09550756B2

公开(公告)日：2017-01-24

申请号：US14517313

申请日：2014-10-17

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Takahiko Taniguchi ,  Jun Kunitomo ,  Masato Yoshikawa ,  Makoto Fushimi

IPC: A61K31/501 ,  C07D403/04 ,  C07D403/14 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  A61K9/20

CPC classification number: C07D403/04 ,  A61K9/2059 ,  C07D401/14 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on.A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

Abstract translation: 本发明提供具有PDE抑制作用的化合物，其可用作预防或治疗精神分裂症等的药物。 式（I 0）的化合物：其中R 1表示取代基，R 2表示氢原子或取代基，R 3表示氢原子或取代基，环A表示可被取代的芳香环， 环B表示可被取代的5元杂芳环或其盐。

公开(公告)号：US12171777B2

公开(公告)日：2024-12-24

申请号：US18310467

申请日：2023-05-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masato Yoshikawa ,  Morihisa Saitoh ,  Taisuke Kato ,  Yayoi Nakayama ,  Tomohiro Seki ,  Yasuo Nakagawa ,  Yusuke Tominari ,  Masaki Seto ,  Yusuke Sasaki ,  Masanori Okaniwa ,  Tsuneo Oda ,  Akito Shibuya ,  Kosuke Hidaka ,  Zenyu Shiokawa ,  Shumpei Murata ,  Atsutoshi Okabe ,  Yoshihisa Nakada ,  Michiyo Mochizuki ,  Brian Scott Freeze ,  Taisuke Tawaraishi ,  Yasufumi Wada ,  Paul D. Greenspan

IPC: A61K31/7084 ,  A61K31/7076 ,  A61K47/68 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US11666594B2

公开(公告)日：2023-06-06

申请号：US17065242

申请日：2020-10-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masato Yoshikawa ,  Morihisa Saitoh ,  Taisuke Kato ,  Yayoi Nakayama ,  Tomohiro Seki ,  Yasuo Nakagawa ,  Yusuke Tominari ,  Masaki Seto ,  Yusuke Sasaki ,  Masanori Okaniwa ,  Tsuneo Oda ,  Akito Shibuya ,  Kosuke Hidaka ,  Zenyu Shiokawa ,  Shumpei Murata ,  Atsutoshi Okabe ,  Yoshihisa Nakada ,  Michiyo Mochizuki ,  Brian Scott Freeze ,  Taisuke Tawaraishi ,  Yasufumi Wada ,  Paul D. Greenspan

IPC: A61K31/7084 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02 ,  A61K47/68 ,  A61K31/7076

CPC classification number: A61K31/7084 ,  A61K31/7076 ,  A61K47/6807 ,  A61P35/00 ,  C07H21/00 ,  C07H21/02

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I):




wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US10406146B2

公开(公告)日：2019-09-10

申请号：US15754934

申请日：2016-08-24

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Akira Kaieda ,  Naoki Ishii ,  Hiroshi Nara ,  Masato Yoshikawa ,  Masaki Daini

IPC: C07D413/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  A61P29/00

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of inflammatory disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10308643B2

公开(公告)日：2019-06-04

申请号：US15210965

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Masashi Toyofuku ,  Masaki Daini ,  Hiroshi Nara ,  Masato Yoshikawa ,  Naoki Ishii ,  Kousuke Hidaka

IPC: C07D413/14 ,  C07D413/04 ,  C07D471/04 ,  C07D491/08 ,  C07D491/107 ,  C07D417/14 ,  C07D498/08

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09624184B2

公开(公告)日：2017-04-18

申请号：US14781665

申请日：2014-04-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Haruhi Ando ,  Tomoaki Hasui ,  Toshiya Nishi

IPC: C07D413/10 ,  C07D491/08 ,  C07D413/12 ,  C07D413/14 ,  C07D263/32 ,  C07D413/04

CPC classification number: C07D263/32 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D491/08

Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.

公开(公告)号：US09296746B2

公开(公告)日：2016-03-29

申请号：US14435899

申请日：2013-10-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Tomoaki Hasui ,  Haruhi Ando ,  Hiromi Fukuda

IPC: C07D413/02 ,  C07D403/02 ,  A61K31/4245 ,  A61K31/416 ,  C07D471/04 ,  C07D519/00 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D413/04 ,  C07D519/00

Abstract: The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。