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    Nanoparticle-based scaffolds and implants, methods for making the same, and applications thereof
    11.
    发明授权
    Nanoparticle-based scaffolds and implants, methods for making the same, and applications thereof 有权

    公开(公告)号：US10716878B2

    公开(公告)日：2020-07-21

    申请号：US14353286

    申请日：2012-10-19

    Applicant: The Regents of the University of California

    Inventor： B. Chia Soo ,  Kang Ting ,  Zhong Zheng

    IPC: A61L27/34 ,  A61L31/16 ,  A61L31/06 ,  A61L27/54 ,  A61C8/00 ,  A61L31/10 ,  A61F2/30 ,  A61F2/44

    Abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

    NANOPARTICLE-BASED SCAFFOLDS AND IMPLANTS, METHODS FOR MAKING THE SAME, AND APPLICATIONS THEREOF
    19.
    发明申请
    NANOPARTICLE-BASED SCAFFOLDS AND IMPLANTS, METHODS FOR MAKING THE SAME, AND APPLICATIONS THEREOF 审中-公开
    基于纳米材料的制品和植入物，其制备方法及其应用

    公开(公告)号：US20140287018A1

    公开(公告)日：2014-09-25

    申请号：US14353286

    申请日：2012-10-19

    Applicant: The Regents of the University of California

    Inventor： B. Chia Soo ,  Kang Ting ,  Zhong Zheng

    IPC: A61L27/34 ,  A61L31/16 ,  A61L31/06 ,  A61L27/54

    Abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

    Abstract translation: 植入相关的细菌感染是矫形外科手术中最严重的并发症之一。 这些感染的治疗通常需要多次手术，器械移除，长期的全身性抗生素和延长康复，并且通常无效，导致更差的临床结果和增加的财务成本。 评估银纳米颗粒/聚（DL-乳酸 - 共 - 乙醇酸）（PLGA）涂层不锈钢合金（SNPSA）作为潜在的抗菌植入材料。 发现SNPSA在体外和体外表现出强烈的抗菌活性，并促进体外培养MC3T3-E1前成骨细胞增殖和成熟。 此外，SNPSA植入物诱导成骨，同时抑制受污染的大鼠股动脉中的细菌存活。 结果表明，SNPSA具有同时的抗菌和骨诱导性能，使其成为矫形外科手术中有希望的治疗材料。

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