-
1.发明授权公开(公告)号：US10716878B2
公开(公告)日：2020-07-21
申请号：US14353286
申请日：2012-10-19
Applicant: The Regents of the University of California
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng
Abstract: Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. Silver nanoparticle/poly(DL-lactic-co-glycolic acid) (PLGA)-coated stainless steel alloy (SNPSA) was evaluated as a potential antimicrobial implant material. It was found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. The results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.
-
公开(公告)号：US09744214B2
公开(公告)日：2017-08-29
申请号：US14106617
申请日：2013-12-13
Applicant: The Regents of the University of California
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng
CPC classification number: A61K38/1841 , A61K38/17 , A61K38/1709 , A61K2300/00
Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.
-
公开(公告)号：US09598480B2
公开(公告)日：2017-03-21
申请号：US13769222
申请日：2013-02-15
Applicant: The Regents of the University of California
IPC: C12N15/06 , C12N15/07 , C12N15/12 , C12N15/19 , C12N15/63 , C12N15/85 , C07K14/475 , C07K14/51 , C12N15/62
CPC classification number: C07K14/475 , C07K14/51 , C07K2319/02 , C07K2319/036 , C12N15/625
Abstract: The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a non-insect secretory signal peptide.
-
公开(公告)号：US20160271186A1
公开(公告)日：2016-09-22
申请号：US15090443
申请日：2016-04-04
Applicant: The Regents of the University of California
Inventor： B. Chia Soo , Kang Ting , Bruno M. Peault
IPC: A61K35/545 , C12N5/077 , A61L31/16 , C12N5/074 , A61L31/08
Abstract: Embodiments of the present invention provide a population of purified perivascular stem cells (PSC) or induced pluripotent stem cells (iPS) and a supernatant of stem cell free from the stem cell, a composition comprising any of these, and a method of using and making them.
-
公开(公告)号：US12186367B2
公开(公告)日：2025-01-07
申请号：US17315593
申请日：2021-05-10
Applicant: The Regents of the University of California
Inventor： Kang Ting , B. Chia Soo
Abstract: This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or ameliorating osteoporosis.
-
Patent Agency Ranking
公开(公告)号：US20220001019A1
公开(公告)日：2022-01-06
申请号：US16839717
申请日：2020-04-03
Applicant: The Regents of the University of California
Inventor： B. Chia Soo , Kang Ting , Benjamin M. Wu
Abstract: The present invention discloses a random conjugate molecule (CMN), comprising a formula of CG-X-N and methods of making and using the same. The present invention also discloses a composition comprising the CMN and methods of making and using the composition.
-
公开(公告)号：US11033605B2
公开(公告)日：2021-06-15
申请号：US15617345
申请日：2017-06-08
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng
Abstract: Provided herein is a method of promoting tissue repair, comprising delivering to a subject a therapeutically effective amount of fibromodulin (FMOD), FMOD polypeptide, FMOD peptide, or a variant or derivative or analog thereof according to a dosing regimen to cause an injured tissue to form a repaired tissue having an improved condition provided that the improved condition does not include improved condition of scar of skin.
-
公开(公告)号：US20210128791A1
公开(公告)日：2021-05-06
申请号：US17073945
申请日：2020-10-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng , Benjamin Wu , Yulong Zhang
Abstract: The application discloses an implantable device, comprising a galvanic redox system formed on a body substrate of the implantable device. The implantable device has a non-zero surface potential when it is deployed. The galvanic redox system comprises a first metal site and a second metal site, the first metal site comprising a first metal having a first metal electrode potential (FMEP) and the second metal site comprising a second metal having a second metal electrode potential (SMEP), which FMEP being lower than SMEP and SMEP being substantially different such that the implantable device is galvanized when it is deployed. Methods of making and using the implantabe device are also disclosed.
-
公开(公告)号：US20140369971A1
公开(公告)日：2014-12-18
申请号：US14353284
申请日：2012-10-22
Applicant: The Regents of the University of California
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng
CPC classification number: C12N5/0696 , A61K35/12 , A61K35/33 , A61K38/1709 , A61K38/18 , C07K14/435 , C12N5/06 , C12N2501/15 , C12N2501/998 , C12N2506/00 , C12N2506/13 , C12N2506/1307
Abstract: The present invention provides a fibromodulin (FMOD) reprogrammed (FReP) cell and a method of making therefor, a culture medium therefor, and a supernatant thereof, and methods of making and using these.
Abstract translation: 本发明提供了一种纤维调节素（FMOD）重编程（FROD）细胞及其制备方法，其培养基及其上清液，以及制备和使用它们的方法。
-
公开(公告)号：US20230002738A1
公开(公告)日：2023-01-05
申请号：US17679745
申请日：2022-02-24
Applicant: The Regents of The University of California
Inventor： B. Chia Soo , Kang Ting , Zhong Zheng
Abstract: The present invention provides a method of treating a disorder using a fibromodulin (FMOD) reprogrammed (FReP) cell. The method comprises administering locally to a human being the FReP cell to a site in need thereof of the human being.
-
-
-
-
-
-
-
-
-
Search Results
27
records
(took 0.023 seconds)
