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公开(公告)号：US11937951B2
公开(公告)日：2024-03-26
申请号：US18159495
申请日：2023-01-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0035 , A61B5/0062 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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Patent Agency Ranking
12.发明公开公开(公告)号：US20230280577A1
公开(公告)日：2023-09-07
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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公开(公告)号：US20230233157A1
公开(公告)日：2023-07-27
申请号：US18159495
申请日：2023-01-25
Applicant: The Trustees of Dartmouth College
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
CPC classification number: A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0062 , A61B5/0035 , A61B2576/00
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
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公开(公告)号：US12061328B2
公开(公告)日：2024-08-13
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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15.发明申请公开(公告)号：US20190384048A1
公开(公告)日：2019-12-19
申请号：US16443760
申请日：2019-06-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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16.发明申请Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores 审中-公开使用多个荧光团差异的医学成像方法和装置公开(公告)号：US20150374308A1
公开(公告)日：2015-12-31
申请号：US14767836
申请日：2014-02-13
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
Abstract translation: 产生受试者组织中靶向荧光团浓度的校正荧光数据的方法包括向受试者施用第一和第二荧光造影剂，靶向目的组织的第一造影剂，第二剂未被靶向。 用第一刺激波长的光照射组织，并以适当的发射波长获取第一数据; 在第二刺激波长照射组织，并且以与第二试剂相关联的第二发射波长获取第二数据，第一和第二发射波长不同。 通过从第一数据中减去第二数据来产生差分数据。 系统提供多个波长的刺激和捕获，具有图像存储和减法代码，以执行该方法。 校正的数据可以形成荧光图像，或用于产生荧光断层图像。
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