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公开(公告)号：US20210003498A1
公开(公告)日：2021-01-07
申请号：US16936138
申请日：2020-07-22
Applicant: The University of Tokyo , Osaka University
Inventor： Sadao Ota , Ryoichi Horisaki , Kazuki Hashimoto
Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
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公开(公告)号：US20240241038A1
公开(公告)日：2024-07-18
申请号：US18512356
申请日：2023-11-17
Applicant: The University of Tokyo , Osaka University
Inventor： Sadao Ota , Ryoichi Horisaki , Kazuki Hashimoto
CPC classification number: G01N21/01 , G01B11/00 , G01N21/53 , G01N21/59 , G01N21/64 , G01N21/6456 , H03M7/3062
Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
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公开(公告)号：US11906722B2
公开(公告)日：2024-02-20
申请号：US18056432
申请日：2022-11-17
Applicant: OSAKA UNIVERSITY , The University of Tokyo
Inventor： Ryoichi Horisaki , Jun Tanida , Sadao Ota
IPC: G02B21/14 , G06F18/214
CPC classification number: G02B21/14 , G01N15/1434 , G06F18/214
Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.
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公开(公告)号：US11861889B2
公开(公告)日：2024-01-02
申请号：US18059846
申请日：2022-11-29
Applicant: The University of Tokyo , OSAKA UNIVERSITY
Inventor： Sadao Ota , Issei Sato , Katsuhito Fujiu , Satoko Yamaguchi , Kayo Waki , Yoko Itahashi , Ryoichi Horisaki
IPC: G01N21/01 , G06V10/82 , G01N15/14 , G01N21/27 , G01N21/64 , G06V20/69 , G06F18/28 , G06F18/21 , G06V10/772 , G06V10/778 , C12M1/34 , G01N21/65 , G01N15/10
CPC classification number: G06V10/82 , C12M1/34 , G01N15/14 , G01N15/1404 , G01N15/147 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N21/01 , G01N21/27 , G01N21/64 , G01N21/65 , G06F18/2178 , G06F18/28 , G06V10/772 , G06V10/7784 , G06V20/698 , G01N2015/1006 , G01N2015/145 , G01N2015/1413 , G01N2015/1415 , G06F2218/12
Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.
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公开(公告)号：US20230237789A1
公开(公告)日：2023-07-27
申请号：US18059846
申请日：2022-11-29
Applicant: The University of Tokyo , OSAKA UNIVERSITY
Inventor： Sadao Ota , Issei Sato , Katsuhito Fujiu , Satoko Yamaguchi , Kayo Waki , Yoko Itahashi , Ryoichi Horisaki
IPC: G06V10/82 , G01N15/14 , G01N21/01 , G01N21/27 , G01N21/64 , G06V20/69 , G06F18/28 , G06F18/21 , G06V10/772 , G06V10/778 , C12M1/34 , G01N21/65
CPC classification number: G06V10/82 , G01N15/14 , G01N21/01 , G01N21/27 , G01N21/64 , G01N15/147 , G01N15/1404 , G01N15/1429 , G01N15/1459 , G01N15/1434 , G06V20/698 , G06F18/28 , G06F18/2178 , G06V10/772 , G06V10/7784 , C12M1/34 , G01N21/65 , G01N2015/1413 , G01N2015/145 , G01N2015/1006
Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.
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Patent Agency Ranking
公开(公告)号：US11549880B2
公开(公告)日：2023-01-10
申请号：US16542257
申请日：2019-08-15
Applicant: Osaka University , The University of Tokyo
Inventor： Ryoichi Horisaki , Jun Tanida , Sadao Ota
Abstract: An electromagnetic wave detecting device comprising: an emission unit configured to emit electromagnetic waves having coherence; an electromagnetic wave modulating unit configured to modulate one or both of a phase and an amplitude of the emitted electromagnetic waves and to change a state of the modulation relative to an imaging target; and a post-modulation electromagnetic wave intensity detecting unit configured to detect an intensity of post-modulation electromagnetic waves, which are the modulated electromagnetic waves acquired by modulating the electromagnetic waves emitted from the emission unit using the imaging target and the electromagnetic wave modulating unit, using one pixel.
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公开(公告)号：US10761011B2
公开(公告)日：2020-09-01
申请号：US15552438
申请日：2016-02-24
Applicant: The University of Tokyo , Osaka University
Inventor： Sadao Ota , Ryoichi Horisaki , Kazuki Hashimoto
Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
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公开(公告)号：US20210120156A1
公开(公告)日：2021-04-22
申请号：US17089028
申请日：2020-11-04
Applicant: Osaka University
Inventor： Ryoichi Horisaki , Jun Tanida , Riki Egami
Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.
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公开(公告)号：US10904415B2
公开(公告)日：2021-01-26
申请号：US16272569
申请日：2019-02-11
Applicant: Osaka University
Inventor： Ryoichi Horisaki , Jun Tanida , Riki Egami
Abstract: An electromagnetic wave phase/amplitude generation device includes a radiation unit configured to radiate electromagnetic waves of a random radiation pattern on a spatial frequency in which a state of the electromagnetic waves to be radiated for each divided region is determined to an imaging object, an imaging unit configured to generate a captured image by imaging scattered electromagnetic waves that are electromagnetic waves generated when the imaging object scatters the electromagnetic waves of the radiation pattern radiated by the radiation unit, and a generation unit configured to generate information indicating at least a phase and amplitude of the electromagnetic waves from the imaging object by performing an arithmetic sparsity constraint operation according to sparsity of the imaging object on the basis of the captured image generated by the imaging unit, information indicating the radiation pattern, and information indicating a signal of the imaging object.
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公开(公告)号：US20210190669A1
公开(公告)日：2021-06-24
申请号：US17115657
申请日：2020-12-08
Applicant: ThinkCyte, Inc. , University of Tokyo , Osaka University
Inventor： Sadao Ota , Ryoichi Horisaki , Yoko Kawamura , Masashi Ugawa , Issei Sato
IPC: G01N15/14
Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry. Image-free GC may achieve accurate and high throughput cell classification as well as selective sorting based on cell morphology without a specific biomarker, which have been challenging using conventional flow cytometers.
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