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    Method for producing biochemical analysis data and apparatus used therefor
    12.
    发明授权
    Method for producing biochemical analysis data and apparatus used therefor 失效
    生化分析数据及其使用方法

    公开(公告)号：US07348587B2

    公开(公告)日：2008-03-25

    申请号：US10175425

    申请日：2002-06-20

    申请人： Hitoshi Shimizu ,  Nobuhiko Ogura

    发明人： Hitoshi Shimizu ,  Nobuhiko Ogura

    IPC分类号： G03B42/08

    CPC分类号： G01N21/76 ,  G01N21/6452 ,  G01N2021/6484

    摘要： A method for producing biochemical analysis data includes the steps of collecting light selectively released from a plurality of light releasable regions two-dimensionally formed to be spaced apart from each other in a sample placed on a sample stage by a plurality of light guide member each of which is disposed to face one of the plurality of light releasable regions, leading the thus collected light to a light detector and photoelectrically detecting the light by the light detector. According to this method, it is possible to produce biochemical analysis data having high quantitative characteristics by photoelectrically detecting light emitted from a plurality of light releasable regions even in the case where the plurality of light releasable regions labeled with a labeling substance are formed in a sample at a high density.

    摘要翻译： 一种生化分析数据的制造方法，其特征在于，在多个导光部件中，通过多个导光部件收集从放置在样品台上的样品彼此间隔开的二维形成的多个可光释放区域中选择性地剥离的光 其被设置为面对多个可光释放区域中的一个，将由此收集的光导向光检测器并通过光检测器光电检测光。 根据该方法，即使在标记有标记物质的多个可光剥离区域形成在样品中的情况下，也可以通过光电检测从多个可光释放区域发出的光来生成具有高定量特性的生化分析数据 以高密度。

    Biochemical analysis data producing method and scanner used therefor
    14.
    发明授权
    Biochemical analysis data producing method and scanner used therefor 失效
    生化分析数据生成方法和扫描仪用于此

    公开(公告)号：US07170078B2

    公开(公告)日：2007-01-30

    申请号：US10141555

    申请日：2002-05-09

    申请人： Hitoshi Shimizu ,  Keiko Neriishi ,  Nobuhiko Ogura

    发明人： Hitoshi Shimizu ,  Keiko Neriishi ,  Nobuhiko Ogura

    IPC分类号： G03B42/08

    CPC分类号： G01N21/6452 ,  G01N21/253 ,  G01N33/54373

    摘要： A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.

    摘要翻译： 生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体 并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为 高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。 根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放 辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

    Toxicity testing apparatus for cell stack cultures
    15.
    发明申请
    Toxicity testing apparatus for cell stack cultures 审中-公开
    细胞堆培养的毒性试验装置

    公开(公告)号：US20070015272A1

    公开(公告)日：2007-01-18

    申请号：US11485274

    申请日：2006-07-13

    申请人： Nobuhiko Ogura ,  Yasuhiro Shimada ,  Satoru Toda ,  Nobufumi Mori

    发明人： Nobuhiko Ogura ,  Yasuhiro Shimada ,  Satoru Toda ,  Nobufumi Mori

    IPC分类号： C12M3/00

    CPC分类号： C12M41/46 ,  C12M23/12 ,  C12M33/04 ,  G01N2035/0427

    摘要： A toxicity testing apparatus for testing toxicity of a sample with respect to a cell stack culture comprises an incubator for incubating at least one cell stack culture, a culture medium exchanger for exchanging a culture medium for the cell stack culture, a sample dispenser for adding the sample to the cell stack culture, and a detector for detecting an effect of the sample with respect to the cell stack culture.

    摘要翻译： 用于测试样品相对于细胞堆叠培养物的毒性的毒性测试装置包括用于孵育至少一个细胞堆叠培养物的培养箱，用于更换用于细胞堆叠培养的培养基的培养基交换器，用于添加 样品到细胞堆培养物，以及检测器，用于检测样品相对于细胞堆培养物的影响。

    Image reading apparatus
    17.
    发明授权
    Image reading apparatus 失效
    图像读取装置

    公开(公告)号：US6130440A

    公开(公告)日：2000-10-10

    申请号：US10142

    申请日：1998-01-21

    申请人： Nobuhiko Ogura

    发明人： Nobuhiko Ogura

    IPC分类号： G01N21/64 ,  G01T1/00 ,  G03B42/02 ,  G03B42/08 ,  G06T1/00 ,  G21K4/00 ,  H04N1/04

    CPC分类号： G03B42/08 ,  G01T1/2012 ,  H04N1/0281

    摘要： An image reading apparatus includes three laser stimulating ray sources for emitting a laser beam, a laser beam scanner for scanning the laser beam, a light detector for photoelectrically detecting light released from an image carrier carrying an image, a scan starting point detector for detecting the laser beam and detecting a scan starting point in a main scanning direction, a laser power adjuster for adjusting power of the laser beam to be projected onto the image carrier in accordance with the kind of the image carrier and a gain switch for switching gain of the scan starting point detector in accordance with the kind of the laser beam and the kind of the image carrier. According to the thus constituted image reading apparatus, it is possible to accurately detect a scan starting point in a main scanning direction of a laser beam to read an image in a radiation diagnosis system, an autoradiographic system, an electron microscope detecting system and a radiation diffraction image detecting system using a stimulable phosphor and a fluorescence detecting system.

    摘要翻译： 图像读取装置包括用于发射激光束的三个激光刺激射线源，用于扫描激光束的激光束扫描器，用于光电检测从携带图像的图像载体释放的光的光检测器，用于检测激光束的扫描起始点检测器 激光束并且在主扫描方向上检测扫描起始点，激光功率调节器，用于根据图像载体的种类调整要投射到图像载体上的激光束的功率，以及增益开关，用于切换 扫描起点检测器根据激光束的种类和图像载体的种类。 根据这样构成的图像读取装置，能够精确地检测激光束的主扫描方向上的扫描起点，以便在放射线诊断系统，放射自显影系统，电子显微镜检测系统和放射线检测系统中读取图像 使用可激发荧光体和荧光检测系统的衍射图像检测系统。

    Scanning apparatus with means to control the frequency of vibrations within the scanner
    18.
    发明授权
    Scanning apparatus with means to control the frequency of vibrations within the scanner 失效
    具有控制扫描仪内振动频率的装置的扫描装置

    公开(公告)号：US5642182A

    公开(公告)日：1997-06-24

    申请号：US580184

    申请日：1995-12-28

    申请人： Yukinori Nishioka ,  Nobuhiko Ogura

    发明人： Yukinori Nishioka ,  Nobuhiko Ogura

    IPC分类号： F16F15/02 ,  H04N1/04 ,  H04N1/06 ,  H04N1/08 ,  G03B27/52 ,  G03B27/42 ,  G03B27/62

    CPC分类号： H04N1/0607 ,  H04N1/0283 ,  H04N1/0635 ,  H04N1/0664 ,  H04N2201/0428

    摘要： A scanning apparatus includes a sheet holder for holding a sheet to be scanned in the shape of a segment of a cylinder, a light source for irradiating the sheet with light, a spinner including a converging lens for converging light from the light source on the surface of the sheet, and a light detector for photoelectrically detecting light from the sheet, a spindle motor including a plurality of rolling balls in a bearing for rotating the spinner coaxially with a center axis of the cylinder, and a sub-scanning device for moving the sheet holder relative to the spinner in a direction parallel to the center axis, and the rolling balls are provided so that the vibrational frequency F of the bearing satisfies the formula Fb/6.ltoreq..vertline.F-n1.times.Fb.vertline..ltoreq.Fb/2 wherein Fb is the rotational frequency of the spindle motor and n1 is a positive integer. According to the thus constituted scanning apparatus, it is possible to read an image which contain no visibly recognizable wave-like unevenness even when the image is read at high density at a reduced scanning pitch.

    摘要翻译： 一种扫描装置，包括用于保持要被扫描的片材的片保持器，其以圆柱体的形式保持，用于用光照射片材的光源，包括会聚透镜的旋转器，用于将来自光源的光会聚在表面上 以及用于光电检测来自片材的光的光检测器，包括在用于与所述圆筒的中心轴线同轴旋转所述旋转器的轴承中的多个滚珠的主轴马达和用于使所述滚筒滚动的副扫描装置， 片保持器相对于旋转器在平行于中心轴线的方向上设置，并且滚珠被设置成使得轴承的振动频率F满足公式Fb / 6

    Reflection density measuring system
    19.
    发明授权
    Reflection density measuring system 失效
    反射密度测量系统

    公开(公告)号：US4823169A

    公开(公告)日：1989-04-18

    申请号：US19402

    申请日：1987-02-26

    申请人： Nobuhiko Ogura

    发明人： Nobuhiko Ogura

    IPC分类号： G01N21/47

    CPC分类号： G01N21/474 ,  G01N2021/478

    摘要： A reflection density measuring system comprises a light source for projecting an irradiation light onto the surface-to-be-measured of a sample and a photodetector which has a photosensor for detecting light reflected by the surface-to-be-measured of the sample to impinge upon the photosensor through a light receiving surface of the photodetector. The distance r between the center of the light receiving surface of the photodetector and the optical axis of the irradiation light is r.sub.o, the distance h between the center of the light receiving surface and the surface-to-be-measured as measured along the optical axis of the irradiation light is h.sub.o, and the angle .theta. which the light receiving surface forms with the surface-to-be-measured is .theta.o, h.sub.o being the value of h at which output I of the photosensor takes a peak value on an output curve representing the change of the output I of the photosensor with the distance h when the distance h is varied under the combination of r.sub.o and .theta.o.

    摘要翻译： 反射浓度测量系统包括用于将照射光投射到待测样品的表面上的光源和具有光检测器的光电检测器，所述光电传感器用于检测被待测表面被反射的光， 通过光电检测器的光接收表面撞击光传感器。 光电检测器的光接收表面的中心与照射光的光轴之间的距离r为ro，光接收表面的中心与沿光学测量的待测表面之间的距离h 照射光的轴为ho，光接收表面与待测表面的角度θ为θo，其为光电传感器的输出I在峰值上的值 输出曲线表示当距离h在ro和θo的组合下变化时具有距离h的光传感器的输出I的变化。