公开(公告)号：US20070293496A1

公开(公告)日：2007-12-20

申请号：US11880756

申请日：2007-07-23

Applicant: Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

Inventor： Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

IPC: A61K31/4965 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61P25/04 ,  C07D401/00 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/445

CPC classification number: C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

Abstract: Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.

公开(公告)号：US07265108B2

公开(公告)日：2007-09-04

申请号：US11173099

申请日：2005-07-01

Applicant: Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

Inventor： Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

IPC: A62K31/535 ,  A62K31/4965 ,  C07D498/00 ,  C07D413/00 ,  C07D241/02

CPC classification number: C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

Abstract: Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.

Abstract translation: 由以下通式表示的化合物：其中X 1，X 2，X 3和X 4各自 独立地表示单键，C 1-6亚烷基等; A 2是任选取代的苯基等; A 1是代表任选取代的含有-C（= Q 1） - 的杂环基团（其中Q 1表示氧原子） ，硫或-NR 11（其中R 11表示氢或C 1-6烷基））和氮等; 和Z 1表示哌啶二基等]，其盐和上述的水合物。

公开(公告)号：US20060292546A1

公开(公告)日：2006-12-28

申请号：US10595858

申请日：2004-11-17

Applicant: Takashi Yoshinaga ,  Toru Arai

Inventor： Takashi Yoshinaga ,  Toru Arai

IPC: C12Q1/00 ,  C07H21/04 ,  C12P21/06 ,  C12N5/08 ,  C12N15/861 ,  C07K14/705

CPC classification number: G01N33/6872 ,  C07K14/705

Abstract: It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high throughput evaluation method. By inserting a hERG gene into a retrovirus vector plasmid or lentivirus vector plasmid to thereby prepare a virus vector, concentrating the vector by ultracentrifugation if necessary, transferring the hERG gene into cells and expressing hERG channels therein, it has become possible to secure an expression level effective in measurements using a fully automated high throughput patch clamp system or dyes.

Abstract translation: 本发明的目的是建立一种建立具有非常高的hERG通道表达水平的细胞的方法，用于预测基于药物研发中的hERG通道抑制的不良反应，从而建立高度敏感和 高通量评估方法。 通过将hERG基因插入到逆转录病毒载体质粒或慢病毒载体质粒中，由此制备病毒载体，如果需要，通过超速离心浓缩载体，将hERG基因转移到细胞中并在其中表达hERG通道，已经可以确保表达水平 使用完全自动化的高通量膜片钳系统或染料测量有效。

公开(公告)号：US5504980A

公开(公告)日：1996-04-09

申请号：US197135

申请日：1994-02-17

Applicant: Takashi Yoshinaga ,  Motohide Yonemura

Inventor： Takashi Yoshinaga ,  Motohide Yonemura

IPC: H03H3/02 ,  H03H9/02 ,  H03H9/10 ,  H03H9/17 ,  H03H9/56 ,  H01L41/22

CPC classification number: H03H3/02 ,  H03H9/1035 ,  Y10T29/42 ,  Y10T29/49172 ,  Y10T29/49798 ,  Y10T29/4981

Abstract: In order to define cavities for vibrating spaces in a chip-type piezoelectric-resonator, which is protected with resin so as to be capable of surface mounting, a mother substrate including a piezoelectric substrate and a plurality of piezoelectric resonance elements formed thereon is prepared, and upraised adhesive layers in the form of walls are provided on respective major surfaces of the mother substrate so as to enclose the vibrating region of the mother substrate. Mother sheets, which are provided with plural cover sheets, are arranged so as to cover both the major surfaces of the mother substrate, thereby defining cavities for vibrating spaces therebetween. Then, protective resin members are applied to cover both the major surfaces of the mother substrate, which in turn is divided to obtain a plurality of chip-type piezoelectric-resonators.

Abstract translation: 为了确定用树脂保护以便能够进行表面安装的芯片式压电谐振器中的振动空间的空腔，制备了包括压电基板和形成在其上的多个压电谐振元件的母基板， 并且在母基板的相应主表面上设置以壁形式提升的粘合剂层，以便包围母基板的振动区域。 设置有多个覆盖片的母片被布置成覆盖母基片的两个主表面，从而形成用于其间的振动空间的空腔。 然后，施加保护树脂构件以覆盖母基板的两个主表面，其又被分割以获得多个芯片型压电谐振器。

公开(公告)号：US07953566B2

公开(公告)日：2011-05-31

申请号：US11573883

申请日：2005-08-22

Applicant: Takashi Yoshinaga

Inventor： Takashi Yoshinaga

IPC: G01R3/00

CPC classification number: G01R31/001 ,  H04B17/345

Abstract: A calculation method of electromagnetic interference reduction through spectrum diffusion that is for reducing the electromagnetic interference, in which, when a center frequency of a measurement bandwidth is changed so that a spectrum having the maximum amplitude is included in the measurement bandwidth, of a plurality of spectra generated from the frequency spectrum of an electromagnetic interference signal through the spectrum diffusion, the amplitudes of all spectra included in the measurement bandwidth are added up and the maximum total sum of the amplitudes is divided by the amplitude of the electromagnetic interference signal, hence to estimate the electromagnetic interference reduction.

Abstract translation: 一种用于减小电磁干扰的频谱扩散的电磁干扰减少的计算方法，其中当测量带宽的中心频率被改变以使得具有最大幅度的频谱包括在测量带宽中时，多个 通过频谱扩散从电磁干扰信号的频谱产生的光谱中，将包括在测量带宽中的所有光谱的幅度相加，并将幅度的最大总和除以电磁干扰信号的幅度，从而 估计电磁干扰降低。

公开(公告)号：US07915274B2

公开(公告)日：2011-03-29

申请号：US11880756

申请日：2007-07-23

Applicant: Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

Inventor： Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

IPC: A01N43/40 ,  A61K31/435 ,  C07D211/68 ,  C07D211/80 ,  C07D213/02

CPC classification number: C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

Abstract: Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.

Abstract translation: 由以下通式表示的化合物：[其中X1，X2，X3和X4各自独立地表示单键，C1-6亚烷基等; A2代表任选取代的苯基等; A1表示含有-C（= Q1） - （其中Q1表示氧，硫或= N-R11（其中R11表示氢或C1-6烷基））和氮等的任选取代的5-至7-元杂环基。 ; Z1表示哌啶二基等]，其盐和上述的水合物。

公开(公告)号：US07002529B2

公开(公告)日：2006-02-21

申请号：US10474426

申请日：2002-03-11

Applicant: Hideki Sasaki ,  Masaharu Imazato ,  Yuji Muramatsu ,  Toshio Kaku ,  Hidenori Muramatsu ,  Toshihide Kuriyama ,  Takashi Yoshinaga

Inventor： Hideki Sasaki ,  Masaharu Imazato ,  Yuji Muramatsu ,  Toshio Kaku ,  Hidenori Muramatsu ,  Toshihide Kuriyama ,  Takashi Yoshinaga

IPC: H01Q1/48

CPC classification number: H01Q1/2275 ,  H01Q1/22 ,  H01Q1/2258 ,  H01Q9/0421 ,  H04B1/38 ,  H04B15/00 ,  H05K1/141 ,  H05K1/16

Abstract: Second ground plane (18), substantially rectangular in shape, is connected to first ground plane (17) mounted with a data processing circuit, and radio communication circuit (12) makes radio communications at communication wavelength λ. A portion of second ground plane (18) from ground connecting means (14) to ground connecting means (33) along continuous edges of second ground plane (18) acts as an antenna. However, since the longest distance a between a plurality of ground connecting means (14, 33) along the continuous edges of second ground plane (18) satisfies “a

Abstract translation: 连接到安装有数据处理电路的第一接地平面（17）上的基本上矩形的第二接地平面（18），无线电通信电路（12）进行通信波长λ的无线电通信。 从地面连接装置（14）到第二接地平面（18）的连续边缘的接地连接装置（33）的第二接地平面（18）的一部分用作天线。 然而，由于沿着第二接地平面（18）的连续边缘的多个接地连接装置（14,33）之间的最长距离a满足“a <λ/ 2alpha”（其中α是等于或大于“ 1“），其谐振频率足够高于无线电通信电路的通信频率。

公开(公告)号：US06995144B2

公开(公告)日：2006-02-07

申请号：US10388185

申请日：2003-03-12

Applicant: Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

Inventor： Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/497 ,  C07D498/00 ,  C07D241/02

CPC classification number: C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

Abstract: The present invention provides compounds represented by the following formula: wherein X1, X2, X3 and X4 each independently represents a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(═Q1)—, Q1 wherein represents oxygen, sulfur or ═N—R11, wherein R11 represents hydrogen or C1-6 alkyl etc.; and Z1 represents piperidin-diyl, ect, salts thereof and hydrates of the foregoing.

Abstract translation: 本发明提供由以下通式表示的化合物：其中X 1，X 2，X 3和X 4， / SUP>各自独立地表示单键，C 1-6亚烷基等; A 2是任选取代的苯基等; A 1是代表任选取代的含有-C（= Q 1） - 的杂环基团（其中Q 1表示氧原子） ，硫或-NR 11（其中R 11表示氢或C 1-6烷基））和氮等; 和Z 1表示哌啶二基等]，其盐和上述的水合物。

公开(公告)号：US20050245527A1

公开(公告)日：2005-11-03

申请号：US11173099

申请日：2005-07-01

Applicant: Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

Inventor： Fumihiro Ozaki ,  Mutsuko Ono ,  Koki Kawano ,  Yoshihiko Norimine ,  Tatsuhiro Onogi ,  Takashi Yoshinaga ,  Kiyoaki Kobayashi ,  Hiroyuki Suzuki ,  Hiroe Minami ,  Kohei Sawada

IPC: A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  A61P3/10 ,  A61P9/00 ,  A61P19/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/24 ,  A61P27/02 ,  A61P31/18 ,  A61P35/00 ,  A61P43/00 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D43/02 ,  A61K31/498 ,  A61K31/513

CPC classification number: C07D401/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/5365 ,  A61K31/55 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06

Abstract: Compounds represented by the following general formula: [wherein X1, X2, X3 and X4 each independently represent a single bond, C1-6 alkylene, etc.; A2 represents optionally substituted phenyl, etc.; A1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q1)- (wherein Q1 represents oxygen, sulfur or ═N—R11 (wherein R11 represents hydrogen or C1-6 alkyl)) and nitrogen, etc.; and Z1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.

Abstract translation: 由以下通式表示的化合物：其中X 1，X 2，X 3和X 4各自 独立地表示单键，C 1-6亚烷基等; A 2是任选取代的苯基等; A 1是代表任选取代的含有-C（= Q 1） - 的杂环基团（其中Q 1表示氧原子） ，硫或-NR 11（其中R 11表示氢或C 1-6烷基））和氮等; 和Z 1表示哌啶二基等]，其盐和上述的水合物。

公开(公告)号：US06784192B2

公开(公告)日：2004-08-31

申请号：US10181560

申请日：2002-07-19

Applicant: Fumihiro Ozaki ,  Toshihiko Kaneko ,  Mutsuko Tabata ,  Yoshinori Takahashi ,  Kazuki Miyazaki ,  Junichi Kamata ,  Ichiro Yoshida ,  Masayuki Matsukura ,  Hiroyuki Suzuki ,  Takashi Yoshinaga ,  Hiroki Ishihara ,  Hiroshi Katoh ,  Kohei Sawada ,  Tatsuhiro Onogi ,  Kiyoaki Kobayashi ,  Miyuki Ohkubo

Inventor： Fumihiro Ozaki ,  Toshihiko Kaneko ,  Mutsuko Tabata ,  Yoshinori Takahashi ,  Kazuki Miyazaki ,  Junichi Kamata ,  Ichiro Yoshida ,  Masayuki Matsukura ,  Hiroyuki Suzuki ,  Takashi Yoshinaga ,  Hiroki Ishihara ,  Hiroshi Katoh ,  Kohei Sawada ,  Tatsuhiro Onogi ,  Kiyoaki Kobayashi ,  Miyuki Ohkubo

IPC: A61K31445

CPC classification number: C07D401/14 ,  C07D401/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.

Abstract translation: 本发明提供具有优异的Na +通道抑制活性的新型化合物。 即，它提供由下式（I）表示的化合物，其盐或它们的水合物。在该式中，环A表示由下式表示的环：其中R 1表示氢原子等 R 2表示氢原子等）等; W表示任选取代的C 1-6亚烷基等; Z表示任选取代的C 6-14芳烃环基等。 l表示0〜6的整数。