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41 条记录 (耗时 0.039 秒)

    Sodium channel inhibitors
    12.
    发明授权
    Sodium channel inhibitors 有权
    钠通道抑制剂

    公开(公告)号：US08853250B2

    公开(公告)日：2014-10-07

    申请号：US12669018

    申请日：2008-07-14

    申请人： Serge Beaudoin ,  Matthew Scott Johnson ,  Brain Edward Marron ,  Mark J. Suto

    发明人： Serge Beaudoin ,  Matthew Scott Johnson ,  Brain Edward Marron ,  Mark J. Suto

    IPC分类号： A01N43/78 ,  A61K31/425 ,  C07D277/52

    CPC分类号： C07D277/52

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
    16.
    发明授权
    Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives 失效
    硝基咪唑的氮丙啶衍生物和选定衍生物的药物组合物

    公开(公告)号：US5036096A

    公开(公告)日：1991-07-30

    申请号：US532529

    申请日：1990-06-04

    申请人： Mark J. Suto

    发明人： Mark J. Suto

    IPC分类号： C07D233/91 ,  C07D403/06 ,  C07D413/06

    CPC分类号： C07D403/06 ,  C07D233/91 ,  C07D413/06

    摘要： The present invention is novel aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives useful as radiosensitizing or chemosensitizing agents in the treatment of hypoxic tumor cells. Also, the present invention is a novel process for preparing both known and novel aziridino derivatives of nitroimidazoles having novel intermediates.

    摘要翻译： 本发明是硝基咪唑的新型氮丙啶衍生物和用作放射增敏剂或化学敏感剂的选定衍生物的药物组合物，用于治疗缺氧性肿瘤细胞。 此外，本发明是制备具有新型中间体的已知和新型硝基咪唑的氮丙啶衍生物的新方法。