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公开(公告)号：US4921859A
公开(公告)日：1990-05-01
申请号：US251153
申请日：1988-09-29
IPC分类号： C07C43/174 , C07C43/178 , C07C43/225 , C07C43/23 , C07D473/00
CPC分类号： C07D473/00 , C07C43/1745 , C07C43/1782 , C07C43/1785 , C07C43/1788 , C07C43/225 , C07C43/23
摘要： Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
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公开(公告)号：US4918219A
公开(公告)日：1990-04-17
申请号：US250892
申请日：1989-09-29
IPC分类号： C07C43/174 , C07C43/178 , C07C43/225 , C07C43/23 , C07C69/157 , C07D473/00
CPC分类号： C07D473/00 , C07C43/1745 , C07C43/1782 , C07C43/1785 , C07C43/1788 , C07C43/225 , C07C43/23
摘要： Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
摘要翻译： 新嘌呤衍生物被描述为用于治疗自身免疫性疾病的药物，以及制造方法和药物组合物以及其制造中的新型中间体。
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公开(公告)号：US4806642A
公开(公告)日：1989-02-21
申请号：US22467
申请日：1987-03-06
IPC分类号： C07C43/174 , C07C43/178 , C07C43/225 , C07C43/23 , C07D473/00 , C07D473/22 , C07D473/30 , C07D473/38 , C07D473/18 , C07D473/24
CPC分类号： C07D473/00 , C07C43/1745 , C07C43/1782 , C07C43/1785 , C07C43/1788 , C07C43/225 , C07C43/23 , C07D473/22 , C07D473/30 , C07D473/38
摘要： Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
摘要翻译： 新嘌呤衍生物被描述为用于治疗自身免疫性疾病的药物，以及制造方法和药物组合物以及其制造中的新型中间体。
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公开(公告)号：US4874862A
公开(公告)日：1989-10-17
申请号：US108658
申请日：1987-10-14
IPC分类号： C07D473/00
CPC分类号： C07D473/00
摘要： Novel guanine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions thereof.
摘要翻译： 新型鸟嘌呤衍生物被描述为用于治疗自身免疫性疾病的药物及其制备方法及其药物组合物。
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公开(公告)号：US4868205A
公开(公告)日：1989-09-19
申请号：US167272
申请日：1988-03-11
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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公开(公告)号：US4868199A
公开(公告)日：1989-09-19
申请号：US167264
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04 , C07D491/048
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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7.发明授权
公开(公告)号：US4761424A
公开(公告)日：1988-08-02
申请号：US782623
申请日：1985-10-01
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D491/048 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/12 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/68 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/60 , C07D333/64 , C07D333/68 , C07D333/70 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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公开(公告)号：US4868200A
公开(公告)日：1989-09-19
申请号：US166146
申请日：1988-03-09
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
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9.发明授权N-substituted-2-hydroxy-.alpha.-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade 失效N-取代-2-羟基-α-氧代苯乙酰胺和具有作为花生四烯酸级联的调节剂的活性的药物组合物
公开(公告)号：US4939133A
公开(公告)日：1990-07-03
申请号：US782763
申请日：1985-10-01
申请人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
发明人： David T. Connor , Daniel L. Flynn , Wiaczeslaw A. Cetenko , Jagadish C. Sircar , Charles F. Schwender , Elizabeth A. Johnson , Roderick J. Sorenson , Paul C. Unangst
IPC分类号： C12N9/99 , A61K31/165 , A61K31/215 , A61K31/24 , A61K31/27 , A61P9/00 , A61P11/00 , A61P25/04 , A61P29/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C67/00 , C07C225/22 , C07C227/00 , C07C229/42 , C07C229/44 , C07C231/02 , C07C233/12 , C07C235/64 , C07C235/72 , C07C301/00 , C07C303/40 , C07C311/00 , C07C313/00 , C07C315/04 , C07C317/46 , C07C317/48 , C07C323/12
CPC分类号： A61K31/165 , C07C233/12
摘要： The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-.alpha.-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention.
摘要翻译： 本发明涉及新型N-取代的2-羟基苯甲酰胺和N-取代的2-羟基-α-氧代 - 乙烯乙酰胺化合物药物组合物，以及用于治疗其中具有脂氧合酶活性的产物有助于 病理状况。 选择的新型中间体也是本发明。
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10.发明授权Enolamides, pharmaceutical compositions and methods of use thereof for treating inflammation 失效烯酰胺，药物组合物及其用于治疗炎症的方法
公开(公告)号：US4921871A
公开(公告)日：1990-05-01
申请号：US121264
申请日：1987-11-16
申请人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
发明人： Mary E. Carethers , Wiaczeslaw A. Cetenko , David T. Connor , Elizabeth A. Johnson , John S. Kiely , Charles F. Schwender , Jagadish C. Sircar , Roderick J. Sorenson , Paul C. Unangst , Robert F. Bruns
IPC分类号： C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D307/92 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
CPC分类号： C07D307/92 , C07D209/36 , C07D209/42 , C07D279/02 , C07D307/83 , C07D307/84 , C07D311/22 , C07D311/24 , C07D333/64 , C07D333/68 , C07D335/06 , C07D491/04
摘要： The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the pathological condition.
摘要翻译： 本发明涉及新型烯醇酰胺型化合物，药物组合物及其使用方法，其可用于治疗其中脂肪氧合酶活性产物或白细胞三烯作用有助于病理状况的疾病。
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