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28 条记录 (耗时 0.023 秒)

    Semiconductor device and method of manufacturing the same
    11.
    发明授权
    Semiconductor device and method of manufacturing the same 失效

    公开(公告)号：US4914498A

    公开(公告)日：1990-04-03

    申请号：US1484

    申请日：1987-01-08

    申请人： Toru Imamura

    发明人： Toru Imamura

    IPC分类号： H01L27/10 ,  H01L21/265 ,  H01L21/3213 ,  H01L21/334 ,  H01L21/60 ,  H01L21/8242 ,  H01L27/108

    CPC分类号： H01L21/76897 ,  H01L21/2652 ,  H01L27/10805 ,  H01L29/66181

    摘要： In a semiconductor device having a thin insulating film of 300 .ANG. or less in thickness on which a conductive layer is provided, the conductive layer is connected to the semiconductor substrate at a position outside the active regions. With such a structure, negative charges accumulated on the conductive layer during the reactive ion etching or ion implantation process can be easily discharged to the semiconductor substrate to prevent a dielectric breakdown of the thin insulating film. In the embodiment, the thin insulating film is a dielectric film of a MOS storage capacitor of a one-transistor type memory cell and the conductive layer is the upper electrode of the MOS capacitor.

    Method of making a capacitor with reduced dielectric breakdown
    12.
    发明授权
    Method of making a capacitor with reduced dielectric breakdown 失效
    制造具有降低的介质击穿电容器的方法

    公开(公告)号：US4713357A

    公开(公告)日：1987-12-15

    申请号：US553944

    申请日：1983-11-21

    申请人： Toru Imamura

    发明人： Toru Imamura

    IPC分类号： H01L27/10 ,  H01L21/265 ,  H01L21/3213 ,  H01L21/334 ,  H01L21/60 ,  H01L21/8242 ,  H01L27/108 ,  H01L21/28

    CPC分类号： H01L21/76897 ,  H01L21/2652 ,  H01L27/10805 ,  H01L29/66181

    摘要： In a semiconductor device having a thin insulating film of 300 .ANG. or less in thickness on which a conductive layer is provided, the conductive layer is connected to the semiconductor substrate at a position outside the active regions. With such a structure, negative charges accumulated on the conductive layer during the reactive ion etching or ion implantation process can be easily discharged to the semiconductor substrate to prevent a dielectric breakdown of the thin insulating film. In the embodiment, the thin insulating film is a dielectric film of a MOS storage capacitor of a one-transistor type memory cell and the conductive layer is the upper electrode of the MOS capacitor.

    摘要翻译： 在具有导电层的厚度为300以下的绝缘薄膜的半导体装置中，导电层在有源区域外侧的位置与半导体基板连接。 通过这样的结构，可以容易地在反应离子蚀刻或离子注入工序中在导电层上累积的负电荷向半导体基板排出，以防止薄绝缘膜发生电介质击穿。 在本实施例中，薄绝缘膜是单晶体管型存储单元的MOS保持电容器的电介质膜，导电层是MOS电容器的上部电极。

    Heparin-binding protein modified with heparan sulfate sugar chains, process for producing the same and pharmaceutical compositions containing the same
    14.
    发明授权
    Heparin-binding protein modified with heparan sulfate sugar chains, process for producing the same and pharmaceutical compositions containing the same 有权
    用硫酸乙酰肝素糖链修饰的肝素结合蛋白，其制备方法和含有它的药物组合物

    公开(公告)号：US07741078B2

    公开(公告)日：2010-06-22

    申请号：US11547346

    申请日：2005-03-31

    申请人： Toru Imamura ,  Masahiro Asada ,  Masashi Suzuki

    发明人： Toru Imamura ,  Masahiro Asada ,  Masashi Suzuki

    IPC分类号： C12N15/12 ,  C12N1/00 ,  C12P21/02

    CPC分类号： C07K14/501 ,  A61K38/00 ,  C07K2319/35

    摘要： A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.

    摘要翻译： 在其分子内具有共价键合的硫酸肝素糖链的肝素结合蛋白是通过将编码可以与硫酸肝素糖链修饰的肽选择性地编码到编码肝素结合蛋白的cDNA并在动物细胞中产生的cDNA来产生的 所得连接的cDNA的基因产物。 这种硫酸乙酰肝素糖链修饰的肝素结合蛋白通过共价键合含有少量硫酸软骨素的糖胺聚糖糖链来官能化。 例如，该肝素结合蛋白质的稳定性优异，例如耐热性，耐酸性，耐碱性和体内稳定性。 此外，硫酸乙酰肝素糖链修饰的肝素结合蛋白对细胞增殖和组织再生有效，具有调节FGFs生理功能的作用。 因此，该肝素结合蛋白作为预防或治疗各种FGF相关疾病的药物是非常有用的。

    Therapeutic Agent for Hair-Related Problems and Method for Screening for the Same
    16.
    发明申请
    Therapeutic Agent for Hair-Related Problems and Method for Screening for the Same 失效
    头发相关问题治疗剂及其筛选方法

    公开(公告)号：US20080139469A1

    公开(公告)日：2008-06-12

    申请号：US11662897

    申请日：2005-09-08

    申请人： Toru Imamura ,  Mitsuko Kawano ,  Akiko Kuramochi ,  Masashi Suzuki ,  Masahiro Asada

    发明人： Toru Imamura ,  Mitsuko Kawano ,  Akiko Kuramochi ,  Masashi Suzuki ,  Masahiro Asada

    IPC分类号： A61K38/18 ,  A61K38/02 ,  A61K31/711 ,  A01K67/00

    CPC分类号： A61K38/1825 ,  A61K8/606 ,  A61K8/64 ,  A61K45/06 ,  A61K48/00 ,  A61Q7/00 ,  C07K14/50 ,  G01N33/5023 ,  G01N2333/50

    摘要： It is intended to elucidate the effect of promoting hair follicle growth and to provide the following therapeutic agents for hair-related problems (1) to (3): (1) a hair growth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; (2) a hair regrowth promoting agent, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide; and (3) a therapeutic agent for alopecia, comprising as an active ingredient an expression vector incorporating a full-length FGF-18, a partial peptide thereof, or a cDNA encoding the full-length FGF-18 or the partial peptide.

    摘要翻译： 旨在阐明促进毛囊生长的效果并提供以下用于毛发相关问题的治疗剂（1）至（3）：（1）毛发生长促进剂，其包含作为活性成分的表达载体，其包含 全长FGF-18，其部分肽或编码全长FGF-18或部分肽的cDNA; （2）一种毛发再生促进剂，其包含作为活性成分的包含全长FGF-18的表达载体，其部分肽或编码全长FGF-18或部分肽的cDNA; 包括作为活性成分的包含全长FGF-18，部分肽或编码全长FGF-18或部分肽的cDNA的表达载体作为活性成分。

    Haparin-Binding Protein Modified with Heparan Sulfate Sugar Chains, Process for Producing the Same and Pharmaceutical Compositions Containing the Same
    17.
    发明申请
    Haparin-Binding Protein Modified with Heparan Sulfate Sugar Chains, Process for Producing the Same and Pharmaceutical Compositions Containing the Same 有权
    用硫酸肝素糖链修饰的Haparin结合蛋白，其制备方法和含有其的药物组合物

    公开(公告)号：US20080119403A1

    公开(公告)日：2008-05-22

    申请号：US11547346

    申请日：2005-03-31

    申请人： Toru Imamura ,  Masahiro Asada ,  Masashi Suzuki

    发明人： Toru Imamura ,  Masahiro Asada ,  Masashi Suzuki

    IPC分类号： A61K31/70 ,  C07K16/00 ,  A61P43/00 ,  C07H21/04 ,  C12P21/04

    CPC分类号： C07K14/501 ,  A61K38/00 ,  C07K2319/35

    摘要： A heparin-binding protein having covalently bonded heparan sulfate sugar chains within its molecule is produced by ligating a cDNA encoding a peptide which can be modified with heparan sulfate sugar chains selectively to a cDNA encoding a heparin-binding protein and producing in an animal cell the gene product of the resultant ligated cDNA. This heparan sulfate sugar chain-modified heparin-binding protein is functionalized by covalently bonding thereto glycosaminoglycan sugar chains containing little chondroitin sulfate. For example, this heparin-binding protein is excellent in stabilities, such as thermostability, acid resistance, alkali resistance and in vivo stability. Further, the heparan sulfate sugar chain-modified heparin-binding protein is effective in cell proliferation and tissue regeneration, and has effect of regulating the physiological functions of FGFs. Thus, this heparin-binding protein is extremely useful as a medicine for preventing or treating various FGF-related diseases.

    摘要翻译： 在其分子内具有共价键合的硫酸肝素糖链的肝素结合蛋白是通过将编码可以与硫酸肝素糖链修饰的肽选择性地编码到编码肝素结合蛋白的cDNA并在动物细胞中产生的cDNA来产生的 所得连接的cDNA的基因产物。 这种硫酸乙酰肝素糖链修饰的肝素结合蛋白通过共价键合含有少量硫酸软骨素的糖胺聚糖糖链来官能化。 例如，该肝素结合蛋白质的稳定性优异，例如耐热性，耐酸性，耐碱性和体内稳定性。 此外，硫酸乙酰肝素糖链修饰的肝素结合蛋白对细胞增殖和组织再生有效，具有调节FGFs生理功能的作用。 因此，该肝素结合蛋白作为预防或治疗各种FGF相关疾病的药物是非常有用的。

    Model Animal for Studying Hair Growth Cycle
    20.
    发明申请
    Model Animal for Studying Hair Growth Cycle 审中-公开
    用于研究头发生长周期的模型动物

    公开(公告)号：US20130174285A1

    公开(公告)日：2013-07-04

    申请号：US13819659

    申请日：2011-09-16

    申请人： Toru Imamura ,  Miho Ueki ,  Yuko Oda

    发明人： Toru Imamura ,  Miho Ueki ,  Yuko Oda

    IPC分类号： A01K67/027

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  G01N33/5088 ,  G01N2333/50

    摘要： The present invention prepared a non-human animal in which Fgf18 gene was knocked out in a keratin-5 positive cell-specific manner using a Cre-loxP system; it provides a non-human model animal in which FGF18 expression has been inhibited in a hair follicle-specific manner to shorten the telogen phase of hair growth cycle. The non-human model animal is useful in studying hair follicles and skin, particularly hair growth occurring cyclically in hair follicle cells, and is applicable to the development of and screening for novel drugs against hair follicle or skin disorders.

    摘要翻译： 本发明制备了使用Cre-loxP系统以角蛋白-5阳性细胞特异性方式敲除Fgf18基因的非人动物; 它提供了一种非人模型动物，其中FGF18表达已经以毛囊特异性方式被抑制以缩短头发生长周期的休止期。 非人类模型动物可用于研究毛囊和皮肤，特别是在毛囊细胞中循环发生的毛发生长，并且可用于开发和筛选针对毛囊或皮肤病的新药。